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Just got off the phone with Defy. They’re keeping me at 150mg (140 dropped my TT a good amount) but 3 times a week to help e2 slightly. No more AI. They’re the best

So my e2 sensitive labs came in at 59. This was 5 days since my last .05mg Adex dose and I haven’t taken any more since. And I feel great again. So f’n weird. I’m sweating a bit at night but otherwise, high libido, morning wood, no bloat. I don’t get it. Speaking to defy today.

Whether actual muscle mass was lost or not, I don’t know, but look/feel very flat. Lost a lot of fullness.

Totally agree and that’s always been the case for me. Mike, Jill, Dr. Calkins, all great!

Update: it’s been a week since I quit my .05mg Anastrozole. Already starting to feel a bit better in the past day or two. Hoping to speak to defy this week and see if I can go to 150mg and no AI. I felt better at 160mg and I clearly feel better without the AI even if my labs say my E2 is high...

Also, this was the day before my true trough day so TT will even be lower when compared to where I was on 160mg (1300+ on trough/injection day)

Nothing outside of lowering from 160mg to 140mg and adding super small doses of Anastrozole. I’m a known over responder as 0.1mg weekly put me down around an e2 of 17 and lower on Clomid monotherapy

So, after 8 weeks in, I was feeling great with maybe a little bit of water retention. Here are those labs. After reviewing with defy, we agreed to lower me from 160mg/week (two 80 week) to 140mg (two 70mg) and add 0.1mg adex per week. No HCG or anything else either course. Fast forward 3...

You’re absolutely right. Apologies and thanks for the reply. I just get confused between the the similarities of low and high e

Thanks. Do these symptoms align with high E2? I always think of low E with night sweats but that can’t be the case here. Again, soaked and doesn’t smell like sweat. The muscle lack of fullness is an odd one, to me

So as I posted in another thread, my E2 came back high (65) after my first 8 weeks at 160mg/week. Didn’t have much symptoms but defy and I agreed to lower me to 140mg/week and 0.1mg to 0.2mg Anastrozole weekly. I know it’ll take time for my dose change to reduce E2 symptoms but a few new things...

They lowered my dose without me pushing it. Actually suggested it on my call yesterday. And pulled DHEA out and said not to start HCG. Great experience for me so far!

Understood. As I said above, after further reflection I’m wondering if moving injection frequency is the most disruptive of the choices. Wondering if adding super low AI or reducing myself down from 80 to 70mg twice a week is the less disruptive way to go since I feel so close to really good...

I’m 40 and feeling like I did in my mid 20s. Bod comp changes, able to have sex with my wife twice per day, etc. Only symptoms I’ve seen from high E2 were that morning erections went away and I’ve been getting a little anxious/crazy. Really trying to keep things close and just clean up the E a...

Yes, my numbers were based off of 80mg wed and sun. Since E2 is high, options were to lower dose at twice per week, move to 3 times per week, or add AI. And yes, thinking of coming down towards 40mg 3 times per week. Should still keep my test in the upper ranges, no?

Hematocrit was 48. Yeah, they want me to stay flat by going to 54mg 3xweek but I may bring that down to 44 or 46mg 3xweek

Per Defy’s suggestion as my E2 is up in the 60s 8 weeks into TRT and me not being fond of the idea of jumping to Anastrozole, they have suggested that I move from twice per week to three times per week to try and lower E2 (my SHBG also went from 67 to 37). Should I consider lowering my dose...

My morning wood went away, mostly. Little bit of water retention. Otherwise I feel good. I spoke with defy today and I told them that I don’t want to go to an AI. So we landed on moving me to three days per week from twice per week at the same total weekly dosage to see if that brings E2 down a...

Yeah I didn’t expect to see IGF go from 130 to 250

Not yet. Trying to keep it simple. We’re done with kids and I don’t care about atrophy. Yes, I know there are other benefits but trying to start simple.

So I’m 40, 8 weeks into TRT at 80mg twice per week. Feeling really good. Had about 2 weeks in. The middle where I felt like I reverted and then went back up to feeling like I did 10 years ago again. Went into this with TT 460 and SHBG at 67. No HCG, no AI. Prior to this, I was on Clomid...

Hi all I’m only 7 weeks into TRT with Defy. All good so far. First follow up in about 2 weeks with labs. Question for the group - I opted to keep things simple and start with just T Cyp @ 80mg twice per week (I have high SHBG). Again, things are going well and couldn’t care less about testicular...

Hi all, I’m 7 weeks into TRT with defy. I’m 40. Was in the mid 400’s TT since my mid 20s and finally felt too low so made the switch from Clomid monotherapy to TRT. Currently at 80mg twice a week. Been doing subq. Felt an immediate lift in mood, morning erections, muscle fullness, etc for the...