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  1. W

    Erection peptide: Pt-141

    Haven't tried it in awhile, but the 3-4 times I did didn't help me much at all. I have an unreconstituted vial around here somewhere, ready to give it another shot.
  2. W

    Obstructive Sleep Apnea and TRT

    I have mild apnea. Could never find a mask that worked, but finally one came out that works well for me. But, after watching this YT channel from an ENT doc in England, I realize for them to work properly you need to be able to breath thru your nose or the pressure wont be comfortable. Also...
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    Using Dopamine Supplements to Hack Motivation: the Neurobiology of Ambition

    Increasing dopamine shouldn't be the goal. Otherwise, cocaine wouldn't be so bad for your brain. Managing increases with return to baseline levels seems to be desired. Andrew Huberman is a professor of neurobiology at Stanford and has a great podcast with all episodes on YouTube. His recent one...
  4. W

    Using Dopamine Supplements to Hack Motivation: the Neurobiology of Ambition

    Increasing dopamine shouldn't be the goal. Otherwise, cocaine wouldn't be so bad for your brain. Managing increases with return to baseline levels seems to be desired. Andrew Huberman is a professor of neurobiology at Stanford and has a great podcast with all episodes on YouTube. His recent one...
  5. W

    Defy Medical alternative

    hmm....my experience has been opposite. Much better than previous provider. And Dr. Saya stays on schedule and provides more time with you to answer pretty much any question you have. That is also not my experience with another doc.
  6. W

    Going from cialis 5mg daily to 2.5

    more likely, your BP is dropping not going up.
  7. W

    Can psychedelics treat depression?

    Jordan Peterson conversation w/ Roland Griffiths - the researcher at Johns Hopkins leading the research into this.
  8. W

    Progesterone Dose for Men

    Did you ever oral progesterone before the cream?
  9. W

    Dr. Thierry Hertoghe

    Dr. Romeo Mariano - was a prolific poster (marianco) on boards several years back. He is in Monterey, California.
  10. W

    Playing with HCG gave me libido

    Consider 250 2x per week instead of EOD (may help keep E2 down) or instead of 100 units a day. Dr. Saya has a small sample size of data showing this provides improved sustained levels vs 100 a day.
  11. W

    Dr. Thierry Hertoghe

    Dr. Mariano always considered him one of the top TRT physicians in Europe.
  12. W

    Testosterone Cream Success (Almost!)

    Is it still working for you?
  13. W

    Histamine, Low Libido and ED

    Then again, maybe I'll just take a handful of mushrooms and reset my HPA: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838010/
  14. W

    Histamine, Low Libido and ED

    For those of us with HPA issues, perhaps something to being low histamine. Much is made of histamine intolerance and much much less is written about the reverse. My horrible libido has always been driven to zero by acid-reducers and when younger (early 20s) by antihistamines for hay fever. I'm...
  15. W

    Histamine, Low Libido and ED

    yes, ranges from ok to low to high. Tried lowering with whatever drug lowers it. No change to libido and felt awful.
  16. W

    Histamine, Low Libido and ED

    https://www.sciencedaily.com/releases/2018/08/180814151001.htm
  17. W

    Histamine, Low Libido and ED

    Then again, I have massive ADHD which would indicate the opposite. So who knows.
  18. W

    Histamine, Low Libido and ED

    Libido and ED as bad as they have ever been. Tried Prog at night per Dr. Saya's recommendation and no help at all. In the last month, I have weaned off HC after being on it for years and I feel a bit calmer without it, but the sexual dept is as stated. 25 years of this. Close to throwing in the...
  19. W

    Progesterone Dose for Men

    DHEA/Cortisol do not have a definitive inverse relationship as someone stated. Both are adrenal hormones. Both can be elevated due to stress. Both can begin to fall after long-term stress. Both don't have to move together. Cortisol would likely have a greater effect on DHEA than DHEA on...
  20. W

    PT-141 and Trimix?

    If it works for ED, then yes. But it NOT working would NOT be evidence of venous leakage.
  21. W

    Anyone supplementing estrogen?

    tested and fine and I supplement
  22. W

    Anyone supplementing estrogen?

    I'm not making that assumption and don't think my issue is hormone related. Perhaps, neurotransmitter, methylation, even wondered about histamine, etc. etc. Libido won't be fixed by an implant though it definitely would provide ability for sex.
  23. W

    Anyone supplementing estrogen?

    pill form - 10mg from Hallandale pharmacy per Dr. Saya's script.
  24. W

    Anyone supplementing estrogen?

    Joined Defy from Dr. Crisler's practice. 10 years of trying it all and no resolution of ED, no libido, he suggested a sequence of things to try. Prog pills at night was on the list. My mood is calmer - though I have also simultaneously learned about the importance of nasal breathing. So, have...
  25. W

    Anyone supplementing estrogen?

    Yeah, I am week into taking it at night before bed. I'm a patient of Dr. Saya. So, far...nothing...worse even.
  26. W

    Anyone supplementing estrogen?

    It's pretty much the only hormone that I haven't tried. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098/
  27. W

    Daily Step Count and Step Intensity With Mortality Among US Adults

    Best purchase I have made during COVID is a Kettlebell - By Far.
  28. W

    The role of androgen therapy in prostate cancer: from TRT to BAT

    From my employer. This isn't new, but still not widespread news. ADT fueling Metastasis - https://www.urmc.rochester.edu/news/story/is-it-time-for-new-strategies-to-treat-aggressive-prostate-cancer
  29. W

    Needing Relationship Advice: Should I just End it?

    There is much to be learned on dynamics within a relationship. However, at some point in your life (he is 39), the games become silly and you have to ask... why do I need to play games? Does it just make me anxious and stressed? Does life/relationships REALLY need to be that way? REALLY?
  30. W

    Needing Relationship Advice: Should I just End it?

    Being married with a kid is different than not married and no kid. After 7 years, if it isn't making him a better person and enriching his life..may be time to move on.
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