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OK, this is starting to make sense. So, with scrotal application, doubling the dose does not double the blood serum levels. Like you say, diminishing returns. Thanks for the link to the study. It and your description helped tremendously.

Maybe I'm comparing apples and oranges. With the scrotal cream protocol, and assuming 40% absorption, you are introducing 80mg a day, and 560mg a week. That is over 2.5x the max dosage I usually see with injection totals (200mg). This is why I feel I must be missing some key point.

I think I am missing something in relation to the scrotal cream application protocols. The scrotal application is recommended as it is 8x more effective than other transdermal applications. Numbers have been posted stating 75-85% absorption with scrotal applications. A common protocol with...