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I and many of the guys here have been known to use such vials for many months. While there's no guarantee something bad won't happen, the odds of that are clearly small. From the standpoint of microbial contamination, you can be less concerned if you're injecting subcutaneously because a shallow...

Allow me to offer an even more conservative perspective. That 100 mg per week of testosterone cypionate would already be giving you more testosterone than most men ever make naturally. The average testosterone production for healthy young men is equivalent to around 60-70 mg of testosterone...

Short answer: It's fine. Long answer: Assuming you mean she takes 0.07 mL TC @ 50 mg/mL, this is 3.5 mg TC. So as you say, taking a quarter of the volume of your 200 mg/mL TC—0.0175 mL—does yield the same 3.5 mg dose of TC. I wouldn't hesitate to do it. Your only issue is the precision of the...

In my estimation, if you preserve daily peak testosterone then the transition should be relatively smooth. Using my own measurements I can give you a rough estimate of how much to lower the dose. Daily cypionate is assumed to give pretty flat serum testosterone. For me, at least, daily...

I wouldn't panic. Particularly for compounded testosterone, the price of the raw material has to be a fairly small fraction of the end product price. Only somewhat more so for UGL. For example, one AI puts the bulk price per kilogram of testosterone cypionate at $500-$2,000. Via Defy Medical...

HCG monotherapy is a reasonable choice given the concerns about fertility. Anecdotes tend to disfavor it with respect to subjective results. This may be due to the potential for excess aromatization. But some guys seem happy with it. Let me throw in Dr. Saya's fertility ranking to give you an...

Usually there's a minimum of 250 IU hCG twice a week up to a maximum of maybe 500 IU three times a week. Around 750-1,000 IU per week in divided doses is typical.

Various options for increasing testosterone while preserving testicular function: TreatmentProsCons Conventional TRT + hCGEffective, usually preserves fertility, higher testosterone levels if neededCost, sometimes extra injections, often excess aromatization, upstream HPTA suppression...

Good discussion and references here: https://www.excelmale.com/threads/hcg-and-elevated-lh-in-alzheimer-patients.25431/

Unfortunately PeakTestosterone.com is gone, so I am unable to point you to threads with guys using dose-tuning to manage primary hypogonadism. Keep in mind that what you've read about suppression when dosing to symptom resolution almost certainly pertains to secondary hypogonadism. Even this...

Cypionate is preferred for its greater reliability and precision in dosing. You'll want to inject at least twice a week so that you'll have a stable background level. Then your natural regulation can do the rest. It's great that your endo wants to target normal LH and FSH. Many would just...

Unfortunately you're getting some mis-targeted advice—because primary hypogonadism is relatively rare. In some respects you are better off than those of us with secondary hypogonadism. Your malady is limited to testicular insufficiency, in contrast to the majority whose maladies involve poorly...

I assume it's highly dependent on both the dose and the individual. Though speculative, it's possible that taking Cistanche extract simultaneously would hedge against suppressive effects. The echinacoside in this extract appears to have SARM-like effects, blocking androgen receptors in the...

Your free testosterone isn't extremely low, so it's borderline whether you should be characterized as hypogonadal. Nonetheless, there are at least some suggestions that very high SHBG like yours may interfere with androgenic activity. Therefore I wouldn't condemn you for wanting to experiment...

What dose size are you targeting? Going with 1 mg/mL is likely more concentrated than you want, especially if you're not using 0.3 cc syringes with half-unit markings. Suppose you're using 1 cc U-100 syringes and want a 2 mg dose. Then you'd be better off with the original dilutions you...

You heard wrong. The normal range for Vermeulen calculated free testosterone is about 7-22 ng/dL, with 13-17 being typical for healthy young men. I've never encountered anyone who is genuinely hypogonadal with cFTV greater than 10 ng/dL. You could be that rare exception, but it's more likely...

You can do either depending on what makes it convenient to take the intended dose. With 50 mg/mL you have 0.5 mg/unit in a U-100 insulin syringe. With 50 mg/ 2 mL = 25 mg/mL you have 0.25 mg/unit. I tend to initially mix 100 mg GHK-Cu with only 1 mL of bacteriostatic water, but my multiple 1...

“However, many commercial labs use an assay that purports to directly measure free testosterone, the so-called direct free testosterone,” Dr. Dunaif says. “This assay has been found to be totally inaccurate and should never be used.” @Dr Justin Saya MD, when is Defy Medical going to stop...

You have good numbers for being on a fairly low dose of enclomiphene. You're responding better than those in the clinical trials, where only the 25 mg cohort had really respectable levels on average.

It is possible. Assuming the injections are comparable to Natesto, which is not a given, then that modest HPTA suppression combined with a little more from hCG might still allow for some LH production. It's probably a situation where different individuals could see different outcomes.

When blending propionate with either enanthate or cypionate I found that getting half of the testosterone from each ester gives a diurnal variation in levels that is at the high end of normal, around +/-25% about the mean, or a 40% drop from peak to trough. We discussed a lot of the nuts and...

No, they are more like Natesto. There's a rapid spike in levels followed by a relatively swift decline. As a standalone TRT method they would need to be used at least 2-3 times daily.

Still a ways off with the Phase 2A trial just getting started. If it continues to look good then it may show up on research chemical sites before FDA approval, depending on its legal status.

Natesto has the evidence behind it. It's the only form of TRT proven to allow continued HPTA function, which in my mind makes it more physiological. Oral forms cause more complete suppression unless accompanied by a SERM. It's likely that appropriately dosed buccal troches would be similar in...

It comes as 100 mg/mL, but I dilute it to 50 mg/mL for quarter-milligram dose resolution.

Suspensions are water-based. In this case there are micronized testosterone particles suspended in the carrier; being hydrophobic they do not dissolve as they would in oil. The injections are spaced six hours apart. No blood work yet, but I am seriously considering doing a sequence of tests to...

The slower the transition, the less the likelihood of side effects. If you limit the reduction to a few milligrams per week then you may not even notice it. But then it will take a few months to complete. With respect to anxiety, have you ever tested your serum progesterone? Frequently it is...

If your goal is primarily to be healthy then be aware that the maximum testosterone production in healthy young men is equivalent to 90-100 mg testosterone cypionate per week, and 60-70 mg is typical. By this standard you are vastly overdosed. The long-term consequences of this are uncertain. We...

Older men do get more "bang for the buck" from testosterone because the metabolic clearance rate declines with age. That is, free testosterone will typically go higher at the same dose as we age. There is no evidence that high levels of testosterone are healthier or to be preferred in any way...

I agree that estradiol is the stronger regulator, but we typically observe that enclomiphene fails to stimulate the HPTA under conventional TRT. This is most likely due to the direct negative feedback of androgens on kisspeptin neurons in the arcuate nucleus. I've suggested that using cistanche...

You have my sympathy. Having experienced something similar, I think people fail to appreciate the dramatic effects menopause can have on some women. It goes well beyond libido, perhaps affecting feelings of empathy and connectedness to significant others. Nominally my wife divorced me because I...