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New to TRT. Received first labs. Concerned and need help.
I will continue to advise newcomers coming to this site with problems that a low-and-slow approach is preferred, backed up by scientific and anecdotal evidence. If you're going to keep butting in with contrary and harmful advice that is unsupported by any serious evidence then you can expect...- Cataceous
- Post #62
- Forum: Blood Test Discussion
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New to TRT. Received first labs. Concerned and need help.
You can repeat this misinformation forever, but the study does not compare physiological to non-physiological doses, and therefore does not support your claim. The fact that a particular dose is tolerated in a short-term dose-response study does not indicate that it is suitable for long-term...- Cataceous
- Post #58
- Forum: Blood Test Discussion
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New to TRT. Received first labs. Concerned and need help.
Which works in this fantasy world of yours where you can only choose between 125 mg/week and 50 mg/week in one dose. As I implied, there's plenty of evidence that physiological doses are safe and effective. It's up to you to prove that non-physiological doses are better, especially because you...- Cataceous
- Post #54
- Forum: Blood Test Discussion
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Less estradiol with faster-acting testosterone?
I wouldn't expect enanthate to be much different from cypionate on similar dosing schedules. But it's perhaps harder to evaluate propionate if you're not measuring area-under-the-curve. Are you saying your E2/T ratio was the same? The limited propionate data I have also doesn't really support...- Cataceous
- Post #3
- Forum: Testosterone Basics & Questions
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Less estradiol with faster-acting testosterone?
Just putting this out for discussion and comments. There have long been anecdotal suggestions that faster-acting testosterone leads to lower overall levels of estradiol. In particular, it's often claimed in regard to using testosterone propionate versus longer esters such as cypionate. It could...- Cataceous
- Thread
- aromatization estradiol fast-acting testosterone trt
- Replies: 4
- Forum: Testosterone Basics & Questions
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New to TRT. Received first labs. Concerned and need help.
Ask yourself why we even have reference ranges. They are used to diagnose and treat disease/dysfunction. The dysfunction is clearly associated with levels above or below the range. I hope you aren't claiming otherwise. For all the supporting studies you claim to have, all you can do is return...- Cataceous
- Post #50
- Forum: Blood Test Discussion
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Testosterone Cypionate vs Testosterone Undecanoate
Really good advice here. Going from TC once every two weeks to TU is like going to the opposite end of the spectrum. You currently have this enormous variation in serum testosterone over each two-week cycle, with troughs being something like 10-20% of peaks, and peaks likely over 1,000 ng/dL...- Cataceous
- Post #14
- Forum: Blood Test Discussion
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New to TRT. Received first labs. Concerned and need help.
It's refreshing to see some marginally clever pushback interspersed with the usual inanities. Unfortunately it falls short, because fitness is good.- Cataceous
- Post #35
- Forum: Blood Test Discussion
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New to TRT. Received first labs. Concerned and need help.
The burden of proof clearly is on you with the extraordinary claim that non-physiological levels are better for overall health and should be the default starting point for TRT. As I went through your list of references it became clear that you had not read them and were relying on a faulty AI...- Cataceous
- Post #34
- Forum: Blood Test Discussion
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New to TRT. Received first labs. Concerned and need help.
In real life men thrive on physiological levels of testosterone. Think the current president @ 441 ng/dL. On TRT some men get away with higher levels, while others suffer side effects and come here, as you well know. What would I do without your incredible wisdom? Maybe I should eat right and...- Cataceous
- Post #31
- Forum: Blood Test Discussion
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New to TRT. Received first labs. Concerned and need help.
I'm not sure what you're referring to. I don't recall even expressing an opinion on the prevalence of this side effect. I did tell you that TRT had the opposite effect on me, with higher doses being somewhat sedating and demotivating. The side effects of excessive testosterone that I've...- Cataceous
- Post #29
- Forum: Blood Test Discussion
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Thyroid Labs for Dixiewrecked
I'm not saying this applies to you, but I went down the thyroid rabbit hole with Defy and now think it's a case of treating the side effects without looking into the underlying cause. I had top-of-range reverse T3, which they treated with a T3 prescription. It brought down rT3, but didn't seem...- Cataceous
- Post #2
- Forum: Thyroid, DHEA, Pregnenolone, Progesterone, etc
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New to TRT. Received first labs. Concerned and need help.
How quickly they forget. After this point-by-point examination of your references you didn't even attempt a response. https://www.excelmale.com/threads/trt-other-medications.32780/post-300919 All this study shows is that being hypogonadal is somewhat worse than being mildly hypergonadal...- Cataceous
- Post #27
- Forum: Blood Test Discussion
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New to TRT. Received first labs. Concerned and need help.
If you recall, I dismantled every one of your purported references. Not one refuted my claims. You basically relied on one study in which no subjects experienced physiological levels of testosterone throughout each injection cycle. Meanwhile, you continue to defend the indefensible: that a...- Cataceous
- Post #24
- Forum: Blood Test Discussion
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Hey everybody.
It's important to have a good idea of free testosterone. Many of the existing tests are inaccurate and even use different scales. Which lab and which test did you use to obtain that figure of 63? What is the normal range? Going by total testosterone alone, TRT would be inadvisable. Also, if...- Cataceous
- Post #2
- Forum: Introductions
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New to TRT. Received first labs. Concerned and need help.
Low SHBG is associated with metabolic syndrome, but it doesn't seem to be an issue in your case. Anecdotally, it appears that men with low SHBG are more likely to have difficulties with TRT. There's also some speculation that low SHBG might impair androgen signaling by reducing the intracellular...- Cataceous
- Post #10
- Forum: Blood Test Discussion
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Experiences and Questions: Personal Experiments with Oral Native Testosterone Base & Enclomiphene (TRT+), Testosterone Propionate, HCG and more
Use this site for Vermeulen free T. With TT of 45.2 nMol/L, SHBG of 37.8 nMol/L and albumin at 4.38 g/dL you get cFTV of 1.08 nMol/L, which is over 31 ng/dL. The top of the normal range for this is in the low 20s. In line with what @FunkOdyssey said, your peak level could easily be two or three...- Cataceous
- Post #32
- Forum: Blood Test Discussion
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New to TRT. Received first labs. Concerned and need help.
While percent free testosterone is not a very useful number in general, that figure of 2.3% is suggesting that your pre-TRT free testosterone was around 11 ng/dL. Is this correct? If that was obtained by equilibrium dialysis then it's not a particularly low number. Your current high free...- Cataceous
- Post #3
- Forum: Blood Test Discussion
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TRT Dose question
It's looking ok so far. The most recent measurement was 29 pg/mL taken about six weeks after dropping to these trivial doses of exogenous testosterone. Still a decent drop from the 40-60 it had been running previously. If anything I might be concerned about the E2/T ratio being high. The...- Cataceous
- Post #59
- Forum: Testosterone Basics & Questions
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TRT Dose question
I developed an aqueous testosterone solution, which I ended up diluting to 10 mg/mL. With my 0.3 cc insulin syringes I have 0.005 mL resolution. The threshold occurred between the dose rate of 0.15 mg testosterone taken three times daily and 0.05 mg testosterone, also three times daily. So this...- Cataceous
- Post #57
- Forum: Testosterone Basics & Questions
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TRT Dose question
I think interference with libido and sexual function by exogenous androgens is much more common than people think, even if not as dramatic as in your case. This was driven home to me by recent experiments in which a difference of 0.3 mg in the daily dose of testosterone made a very large...- Cataceous
- Post #53
- Forum: Testosterone Basics & Questions
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Hey, 27 with mumps orchitis
Assuming normal albumin, Vermeulen calculated free testosterone is around 7 ng/dL, which is on the low side. The normal LH points towards secondary hypogonadism, as does the response to hCG. This would suggest brain mediation—hypothalamic or pituitary—rather than testicular insufficiency...- Cataceous
- Post #4
- Forum: Introductions
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Hey, 27 with mumps orchitis
Do you have an AM total testosterone measurement to go with that SHBG? If you provide these two numbers then we can estimate free testosterone to get a better idea of your status. I assume that normal LH value was measured prior to TRT? Under conventional TRT it's expected to drop to low levels...- Cataceous
- Post #3
- Forum: Introductions
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Hey, 27 with mumps orchitis
You guys who potentially have primary hypogonadism may be interested in a slightly different approach to treatment. Here's one of various posts I've made on the subject: Having residual sexual issues on TRT sometimes means the dose of testosterone is too high, which isn't necessarily related...- Cataceous
- Post #2
- Forum: Introductions
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TRT+ other medications
For young men the effect becomes noticeable in the midrange of testosterone. Here are the data and plotted best-fit equations.- Cataceous
- Post #88
- Forum: Testosterone Basics & Questions
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TRT+ other medications
That's a decent summary in line with speculation over the years. What I'd like to see is an elaboration and quantification of this hypothesis that pulsatile T leads to more efficient E2 clearance and/or less efficient E2 production. The implication is that there's some added...- Cataceous
- Post #73
- Forum: Testosterone Basics & Questions
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TRT+ other medications
Ok, have some TRT 101: Injecting 25 mg of testosterone cypionate is not equivalent to injecting 70% * 25 mg TC = 17.5 mg testosterone, say in the form of suspension or oil-based solution. The latter would be mostly absorbed within the day and would represent a decidedly supraphysiological amount...- Cataceous
- Post #61
- Forum: Testosterone Basics & Questions
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TRT+ other medications
This is true, and the crux of the issue is whether integrated exposure causes the same or similar effects, at least in a susceptible subpopulation. The AI conclusion is that there is such risk. I guess you could argue that careful monitoring might warn you if you are a susceptible individual. In...- Cataceous
- Post #48
- Forum: Testosterone Basics & Questions
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TRT+ other medications
Hard to have a discussion if you won't admit to knowledge of even rudimentary aspects of TRT. Cite studies showing benefits, aside from improved musculature, that extend into above-physiological dosing and levels in a dose-dependent fashion. The only one I found showing benefits is this one. A...- Cataceous
- Post #39
- Forum: Testosterone Basics & Questions
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TRT+ other medications
I suggest you learn about pharmacokinetics. Now include the details that are in the subsequent posts. For example, that "too low" is based on the assumption of levels for healthy young men, as opposed to relative to an age-adjusted healthy reference range. There's also the fact that relatively...- Cataceous
- Post #37
- Forum: Testosterone Basics & Questions
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TRT+ other medications
You have no supporting evidence for that. Most men do well on one of the three doses of Zyosted, and only a small minority is even on the 100 mg dose. No, what irks me is your banal stream of misinformation, which ends up harming men by encouraging them to start with excessive doses or to...- Cataceous
- Post #34
- Forum: Testosterone Basics & Questions
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