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Hi all, During my consultation with Dr Calkin from Defy, he mentioned SHBG artificially inflates Estradiol. I’ve never read this is any of the high SHGB posts I’ve seen on here. My sensitive Estradiol lab reading was 28.9 (8.0-35 pg/ml). Dr Calkin said in reality it’s probably around 15. He...

Hi all, I read some articles that references Dr Crisler regarding Subq injections. From what I read, seemes like Dr Crisler suggests SubQ is 20% more effective than IM as far as absorption and may lower estrogen conversion. Any personal experiences in relation to those benefits?

Hi all, I’m in the process of scheduling a consultation with Defy but also wanted to visit a Urologist in-person for a consultation to discuss TRT and some post vasectomy pain. I have an upcoming appointment with Dr. Melograna from MidAtlantic Urology. Other members have posted about him on...

Good afternoon, After doing more research and reviewing the responses to my other thread, I’ve decided to schedule an appointment with Defy to get a consultation and potentially start a TRT protocol to treat my low free testosterone. I looked back at my lab history over the past 2 years and I...

Hi all, I’ve been treating hypothyroidism over the last 2.5 years and finally after multiple medications and doses i’ve found what works well for me. I take a combination of unithyroid and cytomel along with some iodine. Unfortunately, since I started my treatment, my SHBG has been...