Weird that it negatively affected your lipids. According to two studies on PubMed. Anastrozole negatively affected Breast Cancer women taking the drug whereas Exemestane had a neutral effect on lipids. Guess you’re just an outlier
That’s awesome! I’m going to go ahead and take .25mg/day of anastrozole to knock down my E. I thought exemestane was supposed to be better for lipids. Guess I had to backwards!
Thanks for the advice bro. I’ll just base my free T off of the labs calculation. I will eventually switch to Exemestane for AI once my arimidex runs out to better control my estrogen. I do better (like you) when my estrogen is in the single digits which I believe requires .25mg ED of Anastrozole.
I wish it was more mathematical so you could easily dial it in. TRT is in its infancy it feels and very ambiguous. No one seems to have a perfect answer. It’s also ironic we’re always told to base our TRT protocol on our Free T levels yet nobody can agree on a method of measuring it :(
It just sucks cause there’s such a big difference between the TruT calculation versus the other methods. Which means if you’re basing it off of the other methods and you’re on the very high end of the range, your TruT number would be crazy high
I am officially confused and do not know what Free T value to aim for and which method to use to calculate it.
It seems the consensus is that Free T direct is useless.
My protocol is 15mg/daily of Test Cyp + .25mg Anastrozole EOD
Trough Bloodwork
Total T 705 ng/dl
Estradiol LC/MS 20.8...
Thank you for helping me think rationally. I agree, I probably dropped it too low by decreasing my test dose and increasing my adex dose to ed. I’ll likely just stop the adex for 2 weeks and continue taking it eod after.
Vince, sorry for not giving you the complete picture. I am 12 weeks into a new test cyp daily protocol.
Below are my 6 week labs on 16mg test cyp
daily and .25mg adex EOD
TT: 912.3
FT: 30.1
SHBG: 15.9
E2 Sensitive: 19.8
Based on those 6 week labs I upped my adex from .25mg EOD to .25mg ED...
By bottom out, I meant dropping my E2 drastically lower than my SHBG which is 15.9. I upped my adex dosage in hopes of feeling better and getting my estradiol closer to my SHBG. On my last set of labs 6 weeks in I was on 16mg test daily and .25mg of adex EOD. Below are my 6 week labs:
TT: 912.3...
Yeah it was 19 pg/ML on EOD. I haven’t tested it on .25mg ED after I increased. I just feel way more off than before and not sure how I should proceed.
Does anyone feel like anatrozole affects their memory recall and cognitive abilities? I have been on daily shots with .25mg of adex daily for a few months now and am having ED, issues learning things, and articulating myself. Not sure if I just bottomed out my E or if it might be a side effect...
Dude I know exactly what you mean about injecting SubQ. I’ve been on a new daily protocol injection injecting SubQ for 12 weeks now and it feels like it’s literally made me retarded. Super hard to communicate and form proper sentences. Feels foggy and difficult to critically think. I never felt...
TBH, I think your insomnia issues are related to estrogen conversion. I believe when you are applying additional testosterone you are building up excess estrogen and thus having insomnia. Your SHBG is 10. That’s about as low as they come. Your body can barely handle any estrogen. Seems pretty...
Yes, my mood was greatly enhanced. I felt anxious and socially withdrawn with my E2 too high. I wouldn’t be scared that you’ll crash your E2. People on the internet seem to make a big deal of “crashing”. I personally take a generous dose and have never came close to crashing it. I suppose...
I had the same issue as you when I started TRT. I’ve always had perfect blood pressure, in great shape, and eat healthy. I noticed your E2 is 48.9. That’s pretty high. Especially since your SHBG isn’t that high. My blood pressure was 160/90 at it’s worst and had E2 even higher than you. As soon...
I’ve been on 16mg/day for 6 weeks and that put my free T at 30.1 pg/ml. I’m still well above the lab value range. Vince Carter, do you have any suggestions on if I should cut back my daily dosage and if so by how much to get my free t to just below or at top of range. Low SHBG sucks.
Thanks man. I was either gunna drop to 15mg or 12mg. You think I should drop to 12? It’s really just a guessing game I suppose. And then you retest to see where you’re at.
Not chasing numbers. I have low SHBG and when I’m over the top range of FT I convert more and have more Free T and require higher dose AI to control estrogen. Was aiming for just below top range to see how I do.
My free T is 30.1 pg/ml and TT is 912.3 ng/dl taking 16mg of test c daily. What do you think I can cut my daily dosage to, to achieve a FT number in the 24-25 range. Thanks.
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