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I appreciate your educated guess NeverSayNever. You are certainly getting at why I'm struggling to figure this out on my own: there are really two parts to the puzzle. First, if I absorbed 100% of the T in the cream, how much T is that? Then, second, since I don't absorb 100% of the T in the...

I am considering switching in part because it would be easier to maintain a more constant level of T in my system with injection. I know some think the variation can be a plus, but that's not my experience. I've experimented with spacing out my four clicks of cream throughout the day, but that...

I am currently using 20% compounded cream (200 MG/GM), 4 clicks daily in the a.m. = 1 GM according to the label. That dose has been working well for me. I am thinking about switching to injection and would appreciate knowing what is the equivalent dose -- can anyone walk me through the math? Thanks.

My SHBG was in the 90's. Now it's a little lower, but still in the 70's or 80's. The compounded cream I was prescribed is 200 MG/GM. Dosing takes a little while to figure out, because transdermal absorption varies, person to person. I started with 4 clicks once/day in the a.m., on the underside...

I can relate my own experience: high SHBG (higher than yours), low Free T (by most accurate test available), with Total T in the normal range (by most accurate test available), and I was living with a lot of difficulty getting erections and nowhere near my previous libido. I am 67, and SHBG does...

In West Hollywood, CA, CVS can get it but they don't stock it. so it takes a few days for them to get it.

Really appreciating this thread and all the voices in it. Quick question to be sure I'm understanding something basic: what is the relevant target range that we want to get to in total T and in free T? Sounds like Cataceous and Researchit are suggesting a free T range that is significantly...

Hey Willyt, thanks for telling me about your experience. How long were you on the cream before it started driving down your TT? So far mine has held pretty steady and is in mid to mid-high range of normal.

As for the T cream, my doc believes the low-ish dose I'm on is unlikely to shut down my whole system. It may take me being on this for a few months before we know exactly how my body is reacting to it. At this point, a bit more than 1 month in, I am very happy with the significant incremental...

Yes, I tried Ciomid for several months. It raised my total T lab results but I experienced no change in how I felt and what sex was/ wasn't like. I hear it works for some people, so I wish you good luck. I had no downside trying it, though my estradiol went up I didn't experience any of the mood...

I am only a bit more than 1 month in to low-dose TRT, but I am the type of person you are asking about: high SHBG, in-range total T, low out-of-range free T repeatedly, before any therapy, trying Clomid, and trying Natesto. Now that I am on T cream I am experiencing my first real improvement in...

Hey Cataceous, what unconventional protocols have given you good erections? Mine sometimes are weak, other times become eventually but it sure takes a lot of time and effort to get there. Thanks.

Thanks for your help with this, Cataceous. He told me he was starting me with a low dose, but didn't specify what that meant. Starting low has been his general approach all along, the least possible intervention. But I will see if he can tell me the numeric dose he's intending that I get, and...

Thanks, this is super-helpful. I am just beginning cream but it is not totally clear to me what dose of T I am getting. It's from a compounding pharmacy and the label on the dispenser says T20%, 200 MG/GM. My doc has me starting with 4 clicks 1x daily. If you can help me figure out what amounts...

Thanks, Cataceous, and would you take that same approach if I end up trying skin cream or gel? Aiming to measure the peak, and assume the trough will be very near my regular baseline?

Yes, doing 3x/ day, 1 pump per nostril so 2 pumps, so yes, 33 mg. Thanks for giving me a sense of what the absorption rate might be. I measured T at the trough, not peak -- fasted in the a.m. before doing my first Natesto for the day. Would it be more meaningful to get the peak rather than the...

Oh, one more Natesto question: how many mg of T would I ideally be absorbing from Natesto 3x/day? I'm trying to understand whether the issue is more likely absorption, or whether the dose is just lower than what I need. Thanks for any thoughts on that.

Thanks for this feedback, I agree, I am very happy with my doc. I will even be fine giving Natesto a longer try. I can tell from the discourse in this forum that TRT is great and yet also for some men comes with its own issues or even works significantly less well over time -- and that getting...

I am not sure I fully follow all of the above, but I can say that the general condition that prompted the start of this thread is a condition I share: "normal" total T, high out-of-range SHBG, and low out-of-range Free T and Bioavailable T using the most sensitive tests available from Discounted...

Vince, do you have a recommendation for magnesium supplementation?

Thanks for this insight, Vince. What would you recommend I try?

Thanks, jacb, I just watched the video and will ask my doc about enclomiphene citrate. But I am doubtful it would work as monotherapy for me. Clomid monotherapy worked only on paper, raising my total T quite a bit without reducing my symptoms. I didn't have the side effects others find...

Thanks for this discussion and I agree with jacb that I wonder why high SHBG occurs and whether it is beneficial. By "high" I mean outside the reference range. Similarly, why does SHBG tend to rise as a man ages, what purpose is that serving? I am 67 and my high SHBG seems to impact my free...

I am just starting Natesto 3x/day and am trying to compare how that compares in terms of delivered T to other options such as injection. Anyone know how I can compare apples to apples?

Hey Nelson, quick question for you and others, is the Richard Cavender MD that you had good result with in Ohio the same doc who now has an office in Newport Beach, CA (in addition to his practice in Westerville OH)? I live in L.A. which is why I ask. Thanks.

Thanks for explaining. So the key is to see if my doc is interested and has experience with a compounding pharmacy.

Thanks to both of you, this is super-helpful. TLawyer, what's your experience been being on enclomiphene for over a year? Is it working well for you? About how long were you on it before you got the maximal benefit of it, or are you continuing to have growing benefit even now? I realized Clomid...

I've been on Clomid (no exogenous T, no HCG), for 22 weeks. This is my first experience with any kind of hormone. The change in my labs is big, total T doubling from approx 600 to approx 1200; free T moving from very low outside the reference range to now within the reference range, though still...

What's the best time to test for peak and trough if I am not on any exogenous T? I usually get my blood work done at 9 a.m. or so, fasted, when the nearest lab opens. Would that likely give me peak, trough, or something in-between? Thanks for the guidance.

The Rezum worked great for me. It was done in my doc's office with laughing gas as the anesthetic and I was completely comfortable; not totally out or out of it, and capable of very simple conversation with the doc as he did the procedure; he was able to show me exactly what was happening...

I am 66 years old and have BPH. As it has progressed over time, my symptoms appeared and became worse. I am not an expert on the bladder, but I do know that a digital rectal exam by an experienced primary care doc can tell you a lot about whether and how much your prostate is enlarged. The PSA...