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has anyone ever injected testosterone based on a sliding scale? diabetics will often inject insulin on a sliding scale based upon their daily blood glucose values, and their diet/exercise each day. what about injecting testosterone on a sliding scale based upon symptoms? after 5 years on the...

Oral low dose and topical tamoxifen for breast cancer prevention: modern approaches for an old drug How does this cream work locally given that tamoxifen requires hepatic activation?

This is an issue I've been struggling with for the past couple years. I used to be able to tolerate total testosterone levels of around 1000. But I just turned 50, and now I try to keep my level around 600 to 700. I also stopped HCG since that seemed to make things worse. I also switched to...

Blobs of fat are not meant to be in the bloodstream, and can be harmful when they are. For example, fat embolization syndrome is a well-known sequela of orthopedic injuries. Someone breaks their femur, and little pieces of the marrow enter the bloodstream, showering the lungs with numerous...

I mentioned in my original post that esterified testosterone is not affected by aromatase. I've seen Dr. Saya mention this, and I've seen it posted a few times on various forums, but I just looked, and I cannot find any research to back this up. On the contrary, I found reference to the fact...

Here is an article that lends support to the idea that there is no difference between subq and IM injections in terms of local estrogen conversion:

Could it be that a lot of guys who think they are injecting intramuscularly in the gluteal region are actually injecting subcutaneously?

Don't dis broscience, bro. The average guy on this forum knows more than most of the docs out there prescribing trt. I was first managed by a urologist colleague of mine at a major academic university. His protocol for me was 3000 iu HCG 3x/wk and anastrozole 1mg qday. He didn't even monitor...

Yeah, I have great respect for Dr. Crisler. In a recent interview posted on YouTube, he talked about how 95% of his guys are very happy having switched to subcutaneous, but a small minority do not do well, and it's not clear why. Interestingly, in that same interview, he talked about the...

Yeah, I like to think about these things having a physiology background myself. Sorry if it was overkill. I'm not sitting in a room pulling my hair out over what to do next for myself. I realize that the bottom line is that every protocol has its trade offs, and every individual is different...

Thanks! Were you using an AI at the time?

Here are a couple references and a screencap from a textbook: http://www.sciencedirect.com/science/article/pii/0039128X83900624 https://www.ncbi.nlm.nih.gov/pubmed/26690043

Having found that I have a lowish SHBG (22; normal range 16.5-55.9), and having what I believe to be related clincal symptoms, I've decided to follow the advice of some members of this forum, and increase the frequency of my injections from 2x/wk to daily injections. What I'm now trying to...

In the study mentioned, they were injecting weekly. That means they were injecting a fairly large blob of oil into the subq tissues. Since there is relatively slow absorption from the subq tissues via the lymphatic system and bloodstream, I suspect the residence time for the big blob of oil...

Interesting point. The enanthate contains sesame oil. My new cypionate prescription contains cottonseed oil. I do not know what my old cypionate contained.

I've been having some strange side effects for the past few months: waking up short of breath, brain fog, head pressure, even a couple episodes of nystagmus. I trace these symptoms back to the same time I happened to switch from cypionate to enanthate. I assumed these were essentially...

Here is a study where 100mg SC resulted in the same E2 level as 200mg IM. However, these were weekly injections, not daily.

No breathing problems during the day, but I occasionally have this feeling of increased pressure in my head, and a weird sort of lightheadedness. Otherwise I feel healthy and workout regularly at the gym. I just got back from HIIT training on the Stairmaster tonight, so I don't think it's...

Hmm... Maybe my problem is that I've been decreasing my T levels after years at a high level (I was always at the upper limit, sometimes above). I had zero sleep problems back then.

I'm not really an anxious person, and I don't experience anxiety during the day, so I think it is primarily a breathing issue, though I have to admit when I wake up in the middle of the night, it is in somewhat of a mild panic. I have been having suffocation dreams as well. The sleep doc...

High. Hct is 51. That was on a higher dose of T. Had to give blood. Now on 100mg qweek. Hopefully will be lower. Rechecking H&H. If it is not lower I will be even more suspicious of apnea. Strange thing is I seem to sleep better if I take 10mg DHEA before bed.

Sleep issues On trt 5 yrs. Initially poorly managed on too much T (200 mg IM qweek) and too much AI (1 mg 2x/wk) with very little labwork. Past couple years have been essentially managing myself, 100 mg IM qweek, no AI, and 250iu HCG 3x/wk. Most recent labs total T=850, and free T=29 (upper...

I came across a recent journal article claiming that FSH stimulates production of SHBG by the liver. I cannot post the link to the article (since I'm new to this forum), but you can find it by Googling: Pubmed 28260206 I had always wondered why it is that everyone is so keen on...