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And I'm guessing the challenge is the management of fast metabolism of T. I'm wondering if we know that SHBG *causes* the fast metabolism, or is merely *correlated* with the fast metabolism.

What's the challenge you refer to when you write, "It's a challenge..."?

Losartan is not listed specifically, but its category is listed (ARB - angiotensin receptor blocker - first table, AIIA - angiotensin II antagonist - last table. ARB and AIIA are synonymous).

Yes, thank you very much. I was about to get to work searching for it, but appreciate your posting it!

I almost bought some natto spores to make my own natto, but figured I'd be afraid to eat it. I'd love to try it sometime, though (from someone who knows how to make it properly).

I'm interested too, and will report back. I can't find the thread now, but I read something here about a genetic liver enzyme thing where testosterone is metabolized unusually quickly. If I find it again, I'll ask my doc about it, and post it here. There were links to some ancestry test kit...

Good thought. I checked and my last E2 was 31, so toward the high end but not above the normal range.

Anyone else taking Vit K2 with Vit D? The Vitamin D Council mentions the synergy between the two, and the importance of the combination in keeping calcium out of the arteries and putting it into the bones...

No T flu, but too much anastrozole can definitely cause severe flu symptoms in my (and others) experience.

But you're discounting the 26 mg that I injected the day before, and the day before that, and the day before that (for months)...and the entire concept of "steady state", and the EIGHT day half life of t. cyp. Or so I think. I'm going to see what my doc says in May and will report back then...

So if I test closer to the trough, my T would be higher?

I'm not worried. I'm mostly curious about why my total T hasn't gone up much despite injecting 26 mg/day. While my total T *is* now "normal" (but still under 500), my doc had indicated I'd be up to 800 or 900 after doing a few months @ 26 mg/day of T cyp and HCG twice a week. That's not the...

Thank you, I'll ask my doc about SHBG shots if it's low (she didn't test it yet). The rest of my labs were normal, that's why I didn't post the number. Tests she ordered included CBC, CHEM 14, A1C, PSA, lipid panel, vit D, TSH, T4, T3, Testosterone free and total, sensitive estradiol, and...

I'm not self-directing, though I've done a lot of research before I chose a doc. I have a follow up appt with her in May. She had increased the dose from 75 mg twice a week to 182/week daily without much change. Running the info by you guys here for any other ideas since I have another 7...

Hi Nelson, Here is a pic - .13 daily of 200 mg/ml t cyp...

I'm not sure of the grade, but it's from a compounding pharmacy that sponsors this site. I inject .13 x 200 mg/cc is 26, isn't it?

I'm screwed. But I am feeling a little better even if I'm not into the 900 zone.

No, haven't had that checked. I did mention it in my original post, but I don't know how it would change things. I read there is a relationship between SHBG and T and something about the relationship between metabolism of T that is revealed by SHBG (or something like that). But even so, how...

I was going by steroidcalc where it showed that when you shoot daily, the ups and downs are minimized, which is one of the benefits of daily injections (lower estradiol is another, I've read). Just repsonding, not disagreeing, and apppreciate the feedback which is invaluable coming from those...

It's compounded in grapeseed oil. I think I do half and half IM and subQ. I find that going into fat sometimes causes nodules, so lately have been going into the deltoid or glutes muscles - not shallow IM but definitely IM. But that's only been for the last couple weeks before the draw.

I inject nightly, when I got bed (around 10 or 11 PM). Lab draw was at 8:30 AM the next day. I have been on this protocol for a few months, so figured with daily shots the peak/trough wouldn't be a big deal with respect to draw times.

49 y/o male, 6'0" 260 lbs, low T symptoms for years, on T cyp (180 mg/wk via daily shots) and HCG 400 mg twice a week. T was under 300 before I started the protocol, is now almost 500. Not a big change. My lipds, liver, kideny, CBC are all normal, but my A1C is high normal (5.5). Should I...