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Have you run into any strategies for raising E2 in those of us who are perpetually low? I use HCG and my T is high normal but E2 is constantly very low.

I agree with Funk on the Berberine. Also, there is some evidence that lowering protein may help, and there has been a lot of discussion of that recently in relation to the Sugar Diet (which has been around for decades but has recently be re-publicized). It's not something I think it is viable...

I'm increasingly thinking, both from my own experience and observing others, that what you are describing makes the most sense, but with the addition of other targeted compounds to address specific issues. In your case, a moderate dose of Oxandrolone to replace the "lost" T seems logical (or...

The time for high Vitamin C supplementation no matter what is if you feel any kind of infection/illness coming on. Especially Liposomal Vitamin C. Vitamin C is like the ammo for your innate immune system "gun". It's interesting that it may have raised your HCT since some of us struggle with...

Thanks for posting this. One of the big problems with what I'll call the Minimally Suppressive Testosterone/SERM approaches is the lack of publicly available discussion on the results of such experimentation, so it's interesting to see your results. I had never heard of L-Tyrosine creating those...

I have found that the 250mg version doesn't have even 1 quarter of the flush off the 500 version, so I have switched to taking more of the 250's.

It can make some people smell like Garlic for a little while although I've never had this issue. It does not affect libido. You have to make sure the skiin is clean in the area you apply it. AMidwesternDoctor on substack has done a massive series on it and I suggest you read that. It can...

You might also try DMSO which seems to benefit just about everything.

This is just a wild guess on my part, but a vacuum penis pump might be worth a try. The concept would be that it draws blood into the penis and the increased blood flow might be therapeutic. There was also a study posted here a while back that said Hyperbaric Oxygen Therapy increased vascular...

Several things: - Time Restricted Eating is essential no matter what. Specifically, start by eating within an 8 hour time window so that your are only drinking water for 16 hours per day. Part of insulin resistance appears to be that cells are over-stimulated by constant exposure to insulin, so...

You are making a claim that does not seem to be supported by evidence or logic, so you you need to cite some or expect your position to be challenged. For example, aromatizing compounds are well-known to lead to gyno in some people and be countered by an AI. Gyno is at least partially fat...

I can't remember if I mentioned this before but have you tried timed-release melatonin for sleep? It sounds like some sort of dopamine or cortisol issue but melatonin might help. A spoonful of quality honey before be d might also help if it a low blood sugar issue. Also, I've run across several...

Stress can certainly impact cortisol, so it sounds like that is a prime candidate for your issues. When dealing with any difficult issue however, you want have everything working in your favor, and you want most stored fat in your body to be saturated fat, not PUFAs. Resolution of cellulite is...

I've never used this product but I do use 100% DMSO all the time and it can certainly be a little harsh on the skin in some places. Mixing whatever your normal dose of alphagels with the 70%DMSO/30% aloe-vera blend might reduce the skin issues.

Thanks for posting this. This implies that blood pressure should rise if blood viscosity is in fact rising in a problematic way, however I've had a mysterious rise in HCT with no rise in BP that I can tell. I'm wondering (hoping) that perhaps BP can be used as a way to tell if a rise in HCT is a...

Have you eliminated all seed oils from your diet? Do you have any reason to think your cortisol may have increased? High cortisol can cause abnormal fat deposits (see Cushings Syndrome/Disease).

Personally, if they're the only source, I wouldn't let this scare me away. There's nothing wrong with DMSO and if the DHT works then it works. MT-2 was known to be under-dosed from the non-US/CA sources but it is so strong and you have to dose by experimentation anyway so it doesn't really matter.

"Testosterone stimulates the production of red blood cells (erythropoiesis) by initially increasing erythropoietin (EPO), establishing a new EPO/hemoglobin "set point," This seems underappreciated and could explain why some of us have our HCT jump up and stay up for no apparent reason. On the...

Is it possible you were under-hydrated for the test where your HCT was higher? That could do it.

The issue with sleep and keto (i had the same issue) as I understand it is low blood sugar episodes provoking cortisol release at night which puts the body into an awakened state. You can having your carbs late evening, or having a large serving of glycine late evening. I went away from strict...

I agree with the direction Funk is suggesting which is to look for root cause issues. If viagra is not working that suggests a lack of Nitric Oxide production, so things like Beet Root powder, Nitric Oxide tablets, sunshine and HIIT would be good to try. Bi-mix or Tri-mix would be another option...

Many thanks for taking the time to put that together. My original concern was avoiding iron overload, however in the last year my hematocrit jumped up for no known reason so I am now donating blood a bit more frequently to keep it i check, but I have no symptoms of low iron. I have quercetin on...

Hmmm. A brief experiment with a form of T that leaves your system quickly might be fine as an experiment, however that sounds like some sort of infection or nutrient issue. Have you been to a holistic doc who specializes in fatigue? Lyme disease is very tricky to diagnose but could cause that...

Two questions: 1) since the amount of iron that can be carried by Ferritin can apparently vary massively, how can ferritin alone be a good measure of available iron? My understanding is that TIBC is a better measure but I would be interested in your thoughts, and 2) if someone is trying to...

As other threads have discussed, the dosage to reach a particular blood level can vary from person to person, so there is a degree of experimentation involved. I agree with Vince that starting low and adjusting up after a couple of months if your symptoms dictate is a good approach. What...

More good info in the link below, especially regarding the affect of salt on Zeta Potential and the factors involved in finding healthy salt. https://www.midwesterndoctor.com/p/the-truth-about-salt-efa

I recommend starting with 100-300 mcg (micrograms) and then adjusting upward if necessary. The people who seem to have bad reactions start with higher amounts. For me, it is not a night and day miraculous difference, but a very noticeable bump in the right direction, which I combine with dozens...

No. It requires sun exposure.

For me, the key to the descent is to envision the muscles tensioning like a spring or rubber band, so my cue on the descent is to think “coil, coil,coil…”. This is what powerlifters mean when they say “stay tight”. I only inhale and then hold my breath if necessary until the lift, at which point...

First of all, kudos to you for being open-minded enough to try new things. Most people use an issue as an excuse to stop lifting. Several comments… Something I’ve noticed is that when you injure a joint, the body seems to try to protect itself by immobilizing the joint by locking up the muscles...

Regarding Vitamin C, you can take higher levels while your body is fighting an infection (think of C as being like the bullets for your innate immune system "gun") however I back down as soon as I start to feel better. It will provoke diarrhea if you take too much but I've never had an issue. I...