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    Testicular Atrophy - Any Legitimate Risks?

    I stopped using HCG about a year ago and have noticed considerable atrophy. I saw a urologist yesterday and he seemed concerned that my left testicle was hanging significantly higher than the other (almost one inch higher). He had me cough twice, presumably checking for a hernia, and then he no...
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    Does injection volume have any effect on pharmacokinetics?

    The title pretty much says it all. Is there any difference in terms of absorption, half-life, metabolism, etc if 100mg of testosterone is administered in a 1mL quantity (100mg/mL) vs .5mL (200mg/mL)? My instincts tell me there has to be at least some slight variation. What about even smaller...
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    Which BP medicines are best for erections?

    I know there's a sticky for this, but I was looking to get some anecdotal feedback. I know that ARBs and ACE inhibitors seem to be the best for erectile health. Anyone use drugs like losartan and lisonopril and notice any differences in erectile quality? To my understanding, controlling BP with...
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    Comments/Feedback on my Thyroid Panel

    This bloodwork showcases the amazing power of genetics. I have thalassemia minor, so one of my genes responsible for producing red blood cells consistently pumps out tiny blood cells. Consequently, my hemoglobin/hematocrit are naturally on the low side. I've been using high doses of testosterone...
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    Question about HTPA and Birth Control in Women

    I'm not an expert on the female hormonal cycle, but I do know that when women take birth control, it causes a shut down in LH/FSH much in the same way as exogenous male hormones have the same effect in men. I know that birth control causes a lot of women to feel "off." Could this be for the same...
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    Inducing Hypogonadism in Pets

    I've been wondering about this for a while, but has anyone thought about the fact that when we neuter our pets we essentially force them to live their entire lives hypogonadal? I understand that it's a necessary procedure for various reasons, but it is a shame that we have to remove their...
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    Prefilling Syringes?

    Are there any reasons why one shouldn't prefill their syringes upon receiving their vial of testosterone?
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    Question About DHT

    DHT isn't often measured in routine bloodwork for TRT, but one thing I've noticed is that when it is it's usually never out of range. Like estradiol, DHT is a metabolite of testosterone and one would expect it to go up as testosterone levels rise, but it doesn't seem to rise to the same extent...
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    IM Injection Sites - Do They Matter?

    Excluding subjective pain/discomfort and risk of injury, are there any pharmacological differences between the three major injection sites? I've read in some places that different sites change the absorption rate and even the bioavailability of the testosterone, but I have never seen this on an...
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    First Defy Consultation/HCG

    So I had my first consultation today with the PA at Defy, and apparently it's mandatory that anyone under the age of 30 attempt testosterone "stimulation" before moving on to replacement. Since I already had a horrible experience with clomid, the PA was kind enough to offer HCG monotherapy as an...
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    Somewhat high PSA at age 27 and TRT

    I'm 27 with low T (seems to be idiopathic, my best hypothesis is that it's due to naturally very low cholesterol). I recently did some blood-work for my first consultation with Defy Medical after a disappointing experience several months ago with an endocrinologist (ran Clomid for 2 months, felt...
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