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I stopped using HCG about a year ago and have noticed considerable atrophy. I saw a urologist yesterday and he seemed concerned that my left testicle was hanging significantly higher than the other (almost one inch higher). He had me cough twice, presumably checking for a hernia, and then he no...

The issue with nandrolone is that it wreaks havoc on the arteries. If it weren't for that, I'd be an advocate for its use (although there is some data suggesting it is neurotoxic). For patients with legitimate cachexia, it's one thing to improve their quality of life at the expense of long-term...

Another option is MK-677, which is virtually risk-free (as far as we know), but the effects are much weaker than that of drugs that agonize the androgen receptor.

It's hard to beat nandrolone for that purpose. Testosterone is a very effective muscle builder, and in healthy individuals it is probably equally effective at putting on muscle (more or less) as nandrolone, but it doesn't hold a candle to nandrolone when it comes to reversing cachexia in...

Exactly. On paper it seems like a fantastic compound, and for many decades its deleterious effects on the cardiovascular system were not as well known so it's no surprise many used it with impunity. Unfortunately, it's just not worth the damage.

The problem with nandrolone is that it's insanely damaging to your arteries. According to a study, it hardens your arteries 10x more than testosterone at an equivalent dose. Hypothetically, that means that even if you were to only use 50 mg, you'd get the arterial damage of 500mg of...

There are no such things as "beliefs" when reality is concerned. Your beliefs are objectively false. Androgen administration results in UP-regulation of androgen receptor density, not decrease. In other words, the body does not build resistance to testosterone. You also made absolutely no...

It's pretty much the opposite. Those with low SHBG will wind up with less total and free (contrary to popular belief) testosterone than those with normal levels of SHBG. Generally speaking, those with low SHBG will have a higher free to total testosterone ratio than those with mid-range SHBG...

Your doctor is correct that E2 is a necessary hormone and it wields many health benefits for men, however, having levels that are too high can be problematic for most. You should only change one variable at a time. There are many reasons to believe that HCG is a necessary component of any...

Could be many things. HCG can cause anxiety in some. 5-10 days is enough time for it to clear enough from your system to offer relief. The other possibility is that with your low SHBG, you might feel better with less estradiol. Yours is at the top of the range, which is a bit much for someone...

For me, Quest always gave a higher testosterone result than Lab Corp.

Yours is 19.2. As long as you feel good, that is all that matters.

This question is hard to answer with evidence, but if I had to hypothesize, the ideal SHBG levels would be whatever the average is for young, healthy non-hypogonadal males ages 20-30. I haven't looked at any data, but I'd think this would be in the 20s/30s.

Hi Doctor Mcclain, Legalities aside, are there any androgens besides testosterone that you believe would be beneficial as an adjunct to testosterone for therapeutic purposes?

Please write without ellipses. Your posts are almost unreadable. It sounds to me like you had a run-of-the-mill panic attack. The first time I had one I was only 22 and even I thought I was genuinely having a heart attack. Is it possible that testosterone induced your anxiety? Perhaps, but you...

I stand corrected, but I still no see any evidence for increased receptor down-regulation compared to regular LH at the same concentration.

They actually throw out the top 2.5%, not the top 5.

Unless the guys at Lab Corp were morons, I doubt they would test these levels without including LH/FSH. Anyone who's LH/FSH are in tact would not be on trt.

Bodybuilders use exceptionally large quantities of HCG because their goal is to hard-restart the gonadotropin system after prolonged periods of complete shutdown. They also use exceptionally large doses of SERMs following HCG use as well. HCG is an analog to LH, which means that it is exactly...

I haven't taken a stance on this, because it's a lot like saying "I drink 4 shots of whiskey every day and I'm perfectly healthy." It's true that some people may have fantastic health and longevity while drinking beyond the daily recommended limit (two drinks a day for men), but that certainly...

You ask some really great questions. I refused to take SSRIs when I was severely depressed because I researched them extensively, and discovered that there was great concern for long-term sexual dysfunction. I realized there was no point in being happy if my **** didn't work (not like they'd...

Testosterone is no joke. It's an extremely powerful tool for female to male transgender people. I believe it even provides the benefit of virilizing the bone structure, a utility which male to female transgender people unfortunately don't have at their disposal. As far as I know, there is no...

What an ostensibly random thing to study. How did it occur to them to investigate lavender/tea tree oils and what prepubertal boys do they know that regularly apply lavender and tea tree products? Is it just me or does this apply to virtually no one? When I was 12 or 13 I had some hard...

In reference to the "over range" comments, it doesn't help that Labcorp lowered their reference range July of last year. Some guys had TT levels of 1100 that were considered normal for years, that are now considered over range. Should they be unnecessarily concerned due to some arbitrary change...

Not propecia, but use at your own discretion. Definitely experimental: https://anageninc.com/ru58841-solution-50ml.html?ref=1

I am aware that just because something has not been studied does not mean that it isn't true, but I have not seen these anecdotal accounts either (although I'm sure they exist, as they do for about anything you can imagine). The HCG doses prescribed by clinicians have a relatively low...

Why would HCG stop working? The premise of your hypothesis is that long-term LH deprivation results in deleterious sexual consequences, but there is no logical or scientific basis for the argument that HCG "stops working." If HCG is an analog to LH, then regular concomitant use should have the...

Although currently there is no hard evidence for this, I definitely think you're on to something, especially neurologically/psychologically

What is your daily dosage?

What's your tt on that dose? I've never seen anyone on such a low dose

Post your bloods after 6 weeks on clomid. If your testosterone is extremely high on 12.5 3x a week, you may be able to reduce to 2x a week and find a better sweet spot. Without the sensitive E2 test, trial and error is going to be your best source of truth. Remember that clomid in and of itself...