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I'm a lowish SHBG guy (~19 ref range 19.3-76.4) - started on gels with an endo with limited success and switched to Defy in April. Dr Saya's protocol is subq 44 mg of TestC + 300 IU of HCG 3x/week. Before starting BP normal ~120/83 hematocrit 47.5 (37.5-51.0) Hemoglobin 16.0 (12.6-17.7) PSA...

2 packets of Androgel for a total of 81mg of T - all done per instructions. When I was on 40.5mg, my total T was 180. Endo says "Total T doesn't matter, BAT is good and that's all that matters. Come back in 6 months"

Thanks for the reply. I have no idea why he ordered the Estrone, nor do I understand whether I should be concerned with the level. Insurance paid for tests... Weirdly he did order the sensitive test before starting TRT in November. The regular Estradiol test was 15.4 pg/mL Estradiol, Free...

52 yo male 6'0" 246lbs Started TRT in Early Nov (Total T of 182/Bio Av Test "normal at 109 ng/dL) My Endo tests Estradiol and Estrone - the former is consistently (over 3 labs) <20 pg/ml and the latter has been persistently > 170 pg/ml) SHBG is low (likely insulin resistance) Take 40mg...