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Causes for OSA. A collapsed or narrow airway can be caused by numerous different anatomic changes over time or deformities caused by external forces. Just to give you one example, in my case, I had bicuspid extractions and braces as a child. What that does potentially is cause narrowing of the...

Soft plaque volume increased. Have not heard this before. Has anyone measured their CAC score before and after TRT (then again, a CAC test would only show calcified plaque)? Testosterone Treatment and Coronary Artery Plaque Volume in Men With Low Testosterone...

Never as good as I want it, but not on TRT currently. This news adds more fuel to the pro-TRT fire for me though.

https://www.snpedia.com/index.php/Orientation

"Body composition analysis showed that the CC genotype of rs1062033, and the AA genotype of rs700518, had significant increase in total lean and appendicular lean mass compared to CG and GG, and AG and GG, respectively." I won the genetic lottery on this one! I am CC and TT (AA) respectively...

Excerpted from Chris Masterjohn's, PhD newsletter: A preprint* released yesterday by collaborators from the medical schools of Stanford, Columbia, University of Minnesota, UC San Diego, and Taiwan's China Medical School provided the first evidence of the expression of ACE2 in the upper...

supportive: https://www.frontiersin.org/articles/10.3389/fimmu.2018.00336/full...

What about n-3's (i.e. marine lipids)?

Interesting. Thanks. Keep us posted on more results from this protocol. https://www.ncbi.nlm.nih.gov/pubmed/8724115 Have you looked into the new Rx for FH, Nexletol? Less side effects than statins...

ARB Telmisartan effective for those already infected, but what about for prophylaxis??? https://www.ncbi.nlm.nih.gov/pubmed/32356926

UPDATE FROM MEDCRAM:

https://www.reuters.com/article/us-health-conoravirus-blood-pressure-ins/blood-pressure-drugs-are-in-the-crosshairs-of-covid-19-research-idUSKCN2251GQ

https://www.the-scientist.com/news-opinion/blood-pressure-meds-point-the-way-to-possible-covid-19-treatment-67371?fbclid=IwAR1SvNF5rIs12tK2I2HI5A2OqGuQWh7Ps5J4psPfLQcrkw7dmT5FGGfIZck

https://www.cebm.net/covid-19/angiotensin-converting-enzyme-ace-inhibitors-and-angiotensin-receptor-blockers-in-covid-19/

Much of the controversy about the positive or negative effect of ARB/ACEI is based on a time confusion. The positive effect of ACE2 would only occur AFTER the SARS-CoV-2 entered into the target cells. On the opposite, BEFORE its entry, the ACE2 availability may potently increase the number of...

https://www.cebm.net/covid-19/angiotensin-converting-enzyme-ace-inhibitors-and-angiotensin-receptor-blockers-in-covid-19/ https://www.cebm.net/wp-content/uploads/2020/03/ACEI-ARB-recommendations-BMJ-1.png

https://www.bmj.com/content/368/bmj.m406/rr-2

Skip to 23:33. This is troubling. Jay's guest, Anthony Jay, PhD, fails to mention the more recent contrarian argument that we've been making in which upregulation of ACE2 via ACEIs and ARBs can actually be protective and block the virus from entry (and the fact that Losartan is in clinical...

https://clinicaltrials.gov/ct2/show/NCT04312009

One thing to keep in mind is that people lacking vitamin D (greater in elderly and those with little or no sunlight exposure) have a weaker innate immune defense against SARS-CoV-2.

Encouraging video:

https://blogs.sciencemag.org/pipeline/archives/2020/03/17/angiotensin-and-the-coronavirus

Following is an email from Chris Kresser regarding upregulation of ACE2 receptors from certain supplements. Based on what he's saying, anything that can increase expression of ACE2 receptors is theoretically at risk. All ACEIs and ARBs already do this, and, according to Chris, if we're taking...

Here's a video from Dr. Ford Brewer regarding this issue. He himself is on lisinopril. I'm on telmisartan.

For anyone taking an ARB like Losartan or an ACE (i.e. Lisinopril), there are a bevy of conflicting reports as to whether these meds are protective or facilitate coronavirus infection. PROS: Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. - PubMed - NCBI Use of angiotensin...

Yes, it's the pure powder from PCCA which is the largest distributor. I actually found the source and then found a compounding pharmacy to order it and compound it for me. I have tried every combination of thyroid meds available except for synthetic T4/T3. I don't see any reason to switch to a...

23andme.com will give you what you need and more. It has been a roadmap to my genome. I am now taking a custom compounded NDT free of fillers or binders with only ascorbic acid added (actually supposed help with T3 metabolism as a bonus). I was taking NP Thyroid and may have to resume if the...

Have you found out why serum iron is normal to high but ferritin won't budge? Some claim it's due to a methylation problem, but I haven't found any science to back that up. I just think it takes a long time, like months, to replete ferritin whereas serum will replete within days. BTW, my serum...

I can't believe that after 5 years, his assessments remain a one-way ticket to another dead end: staying hypogonadal which is no better option. Also, T reduces Lp(a): Testosterone-induced suppression of lipoprotein(a) in normal men; relation to basal lipoprotein(a) level. - PubMed - NCBI To...