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New DRUG May Lower SHBG In the Future

For those with either NAFLD/NASH or high lipids (trigylcerides, ldl, etc), a drug called mgl-3196 by Madrigal Pharm. just concluded its phase 2 trial and patients had an average of their SHBG increasing 80% from baseline with some over 100%. Drug also statistically significantly lowered...
- Jpin22
- Thread
- Mar 13, 2019
- ldl lipids shbg
- Replies: 1
- Forum: Testosterone Basics & Questions
J
Low MCV and MCH, High RBC and RDW

Rdw 17.2 ref range 12.3-15.4 RBC 6.33 ref range 4.14-5.8 MCV 78 ref range 79-97 MCH 26.4 ref range 26.6-33 Thoughts? I have fatigue and shortness of breath. On Trt - 160mg divided into 2 doses a week.What should I get checked? Iron? Ferritin? Thanks
- Jpin22
- Thread
- Dec 26, 2017
- Replies: 14
- Forum: Blood Test Discussion
J
Low SHBG guys

Im a low SHBG guy (usually single digits). Do you have muscle loss/weakness? Fasciculations (muscle twitching)? Raised triglycerides? Heat intolerance? Abdominal weight gain? Shortness of Breath? Exercise intolerance? Any other symptoms?
- Jpin22
- Thread
- Oct 25, 2017
- Replies: 45
- Forum: Testosterone Basics & Questions
J
Trying to Solve the Problem of Why I Don't Feel Good

Been with Defy for awhile and have nothing but good things to say about them. Besides some cognitive benefits of not having low T, I dont feel a whole lot of from TRT. TRT protocol is 160 mg a week split in two doses and HCG. I used to be a 5-6 day a week gym guy and was in very good shape...
- Jpin22
- Thread
- Apr 26, 2017
- Replies: 6
- Forum: Testosterone Basics & Questions
J
Low SHBG: Insulin Resistance?

I'm quite positive I'm insulin resistant with an out of range low SHBG and I'm looking into metformin. TRT so far hasn't been anywhere near effective as I thought it'd be and I am realizing that it is most likely (hopefully) because of the low SHBG and insulin resistance.
- Jpin22
- Thread
- Mar 28, 2016
- Replies: 15
- Forum: When TRT Is Not Enough (ED, Libido, & More)
J
Testosterone, weight loss, and other questions

Hey everyone, new to the forum. Late 20s male, 3 weeks into trt with Defy and Dr Saya. On a 160mg a week twice a week and Hcg 350 mg 2x a week. So far haven't really noticed anything but wasn't really expecting to. A couple years ago started feeling awful and have had a host of symptoms. I...
- Jpin22
- Thread
- Feb 15, 2016
- Replies: 9
- Forum: Testosterone Basics & Questions

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038