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I'm not saying this applies to you, but I went down the thyroid rabbit hole with Defy and now think it's a case of treating the side effects without looking into the underlying cause. I had top-of-range reverse T3, which they treated with a T3 prescription. It brought down rT3, but didn't seem...

How quickly they forget. After this point-by-point examination of your references you didn't even attempt a response. https://www.excelmale.com/threads/trt-other-medications.32780/post-300919 All this study shows is that being hypogonadal is somewhat worse than being mildly hypergonadal...

If you recall, I dismantled every one of your purported references. Not one refuted my claims. You basically relied on one study in which no subjects experienced physiological levels of testosterone throughout each injection cycle. Meanwhile, you continue to defend the indefensible: that a...

It's important to have a good idea of free testosterone. Many of the existing tests are inaccurate and even use different scales. Which lab and which test did you use to obtain that figure of 63? What is the normal range? Going by total testosterone alone, TRT would be inadvisable. Also, if...

Low SHBG is associated with metabolic syndrome, but it doesn't seem to be an issue in your case. Anecdotally, it appears that men with low SHBG are more likely to have difficulties with TRT. There's also some speculation that low SHBG might impair androgen signaling by reducing the intracellular...

Use this site for Vermeulen free T. With TT of 45.2 nMol/L, SHBG of 37.8 nMol/L and albumin at 4.38 g/dL you get cFTV of 1.08 nMol/L, which is over 31 ng/dL. The top of the normal range for this is in the low 20s. In line with what @FunkOdyssey said, your peak level could easily be two or three...

While percent free testosterone is not a very useful number in general, that figure of 2.3% is suggesting that your pre-TRT free testosterone was around 11 ng/dL. Is this correct? If that was obtained by equilibrium dialysis then it's not a particularly low number. Your current high free...

It's looking ok so far. The most recent measurement was 29 pg/mL taken about six weeks after dropping to these trivial doses of exogenous testosterone. Still a decent drop from the 40-60 it had been running previously. If anything I might be concerned about the E2/T ratio being high. The...

I developed an aqueous testosterone solution, which I ended up diluting to 10 mg/mL. With my 0.3 cc insulin syringes I have 0.005 mL resolution. The threshold occurred between the dose rate of 0.15 mg testosterone taken three times daily and 0.05 mg testosterone, also three times daily. So this...

I think interference with libido and sexual function by exogenous androgens is much more common than people think, even if not as dramatic as in your case. This was driven home to me by recent experiments in which a difference of 0.3 mg in the daily dose of testosterone made a very large...

Assuming normal albumin, Vermeulen calculated free testosterone is around 7 ng/dL, which is on the low side. The normal LH points towards secondary hypogonadism, as does the response to hCG. This would suggest brain mediation—hypothalamic or pituitary—rather than testicular insufficiency...

Do you have an AM total testosterone measurement to go with that SHBG? If you provide these two numbers then we can estimate free testosterone to get a better idea of your status. I assume that normal LH value was measured prior to TRT? Under conventional TRT it's expected to drop to low levels...

You guys who potentially have primary hypogonadism may be interested in a slightly different approach to treatment. Here's one of various posts I've made on the subject: Having residual sexual issues on TRT sometimes means the dose of testosterone is too high, which isn't necessarily related...

For young men the effect becomes noticeable in the midrange of testosterone. Here are the data and plotted best-fit equations.