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It's looking ok so far. The most recent measurement was 29 pg/mL taken about six weeks after dropping to these trivial doses of exogenous testosterone. Still a decent drop from the 40-60 it had been running previously. If anything I might be concerned about the E2/T ratio being high. The...

I developed an aqueous testosterone solution, which I ended up diluting to 10 mg/mL. With my 0.3 cc insulin syringes I have 0.005 mL resolution. The threshold occurred between the dose rate of 0.15 mg testosterone taken three times daily and 0.05 mg testosterone, also three times daily. So this...

I think interference with libido and sexual function by exogenous androgens is much more common than people think, even if not as dramatic as in your case. This was driven home to me by recent experiments in which a difference of 0.3 mg in the daily dose of testosterone made a very large...

Assuming normal albumin, Vermeulen calculated free testosterone is around 7 ng/dL, which is on the low side. The normal LH points towards secondary hypogonadism, as does the response to hCG. This would suggest brain mediation—hypothalamic or pituitary—rather than testicular insufficiency...

Do you have an AM total testosterone measurement to go with that SHBG? If you provide these two numbers then we can estimate free testosterone to get a better idea of your status. I assume that normal LH value was measured prior to TRT? Under conventional TRT it's expected to drop to low levels...

You guys who potentially have primary hypogonadism may be interested in a slightly different approach to treatment. Here's one of various posts I've made on the subject: Having residual sexual issues on TRT sometimes means the dose of testosterone is too high, which isn't necessarily related...

For young men the effect becomes noticeable in the midrange of testosterone. Here are the data and plotted best-fit equations.

That's a decent summary in line with speculation over the years. What I'd like to see is an elaboration and quantification of this hypothesis that pulsatile T leads to more efficient E2 clearance and/or less efficient E2 production. The implication is that there's some added...

Ok, have some TRT 101: Injecting 25 mg of testosterone cypionate is not equivalent to injecting 70% * 25 mg TC = 17.5 mg testosterone, say in the form of suspension or oil-based solution. The latter would be mostly absorbed within the day and would represent a decidedly supraphysiological amount...

This is true, and the crux of the issue is whether integrated exposure causes the same or similar effects, at least in a susceptible subpopulation. The AI conclusion is that there is such risk. I guess you could argue that careful monitoring might warn you if you are a susceptible individual. In...

Hard to have a discussion if you won't admit to knowledge of even rudimentary aspects of TRT. Cite studies showing benefits, aside from improved musculature, that extend into above-physiological dosing and levels in a dose-dependent fashion. The only one I found showing benefits is this one. A...

I suggest you learn about pharmacokinetics. Now include the details that are in the subsequent posts. For example, that "too low" is based on the assumption of levels for healthy young men, as opposed to relative to an age-adjusted healthy reference range. There's also the fact that relatively...

You have no supporting evidence for that. Most men do well on one of the three doses of Zyosted, and only a small minority is even on the 100 mg dose. No, what irks me is your banal stream of misinformation, which ends up harming men by encouraging them to start with excessive doses or to...

Because virtually nobody is producing 12 mg of testosterone per day naturally. This mischaracterizes what I said. It may not be optimal for a slight majority, but in divided doses it would resolve some of the worst symptoms of hypogonadism. The reason for the low-and-slow approach is that many...