Search results

That's a decent summary in line with speculation over the years. What I'd like to see is an elaboration and quantification of this hypothesis that pulsatile T leads to more efficient E2 clearance and/or less efficient E2 production. The implication is that there's some added...

Ok, have some TRT 101: Injecting 25 mg of testosterone cypionate is not equivalent to injecting 70% * 25 mg TC = 17.5 mg testosterone, say in the form of suspension or oil-based solution. The latter would be mostly absorbed within the day and would represent a decidedly supraphysiological amount...

This is true, and the crux of the issue is whether integrated exposure causes the same or similar effects, at least in a susceptible subpopulation. The AI conclusion is that there is such risk. I guess you could argue that careful monitoring might warn you if you are a susceptible individual. In...

Hard to have a discussion if you won't admit to knowledge of even rudimentary aspects of TRT. Cite studies showing benefits, aside from improved musculature, that extend into above-physiological dosing and levels in a dose-dependent fashion. The only one I found showing benefits is this one. A...

I suggest you learn about pharmacokinetics. Now include the details that are in the subsequent posts. For example, that "too low" is based on the assumption of levels for healthy young men, as opposed to relative to an age-adjusted healthy reference range. There's also the fact that relatively...

You have no supporting evidence for that. Most men do well on one of the three doses of Zyosted, and only a small minority is even on the 100 mg dose. No, what irks me is your banal stream of misinformation, which ends up harming men by encouraging them to start with excessive doses or to...

Because virtually nobody is producing 12 mg of testosterone per day naturally. This mischaracterizes what I said. It may not be optimal for a slight majority, but in divided doses it would resolve some of the worst symptoms of hypogonadism. The reason for the low-and-slow approach is that many...

Wrong. Virtually nobody is naturally producing 12.5 mg T per day, so 125 mg TC/week is decidedly non-physiological for anybody. People like you can tolerate it, but that doesn't change my position that it's foolish to start "TRT" with such doses, and it's unlikely that such doses are optimal for...

Yet this phrase seems to come up when people want to skip directly to high doses without bothering to explore the physiological range first, which ironically is treating by numbers anyway. Yes, there are plenty of testimonials about the harm done in trying to make bigger doses work, as with...

In theory, though it could be overstated. It would imply that a 1 mg dose would raise TT by around 2,000 ng/dL. I might use this dose for testing next time—in order to improve the signal-to-noise ratio. I'm not even going to attempt HPTA suppression, but if TT levels really hit well over 1,000...

This is highly misleading due to using trough values on weekly injections. That 125 mg dose is supraphysiological except near the end of each injection cycle.

Unfortunately your priorities are likely at cross-purposes. Some nontrivial fraction of men must choose between overall health—and sexual health in particular—and high-level physical performance. You can read about the experiences of others in this post. I would argue that your doses are above...

Here's an interim update on this research. It had become clear that if I wanted to continue using small-gauge needles, e.g. 31 gauge, then I needed to create an aqueous solution; the particle sizes in even partial suspensions were too large to get a predictable dose. A new formulation that...

There is a possible middle ground, which is topical finasteride, along with topical and/or oral minoxidil. I had unpleasant side effects from oral finasteride, and it took some time to make the connection and then recover. But as hair loss resumed I eventually gambled on going the topical route...