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Yet this phrase seems to come up when people want to skip directly to high doses without bothering to explore the physiological range first, which ironically is treating by numbers anyway. Yes, there are plenty of testimonials about the harm done in trying to make bigger doses work, as with...

In theory, though it could be overstated. It would imply that a 1 mg dose would raise TT by around 2,000 ng/dL. I might use this dose for testing next time—in order to improve the signal-to-noise ratio. I'm not even going to attempt HPTA suppression, but if TT levels really hit well over 1,000...

This is highly misleading due to using trough values on weekly injections. That 125 mg dose is supraphysiological except near the end of each injection cycle.

Unfortunately your priorities are likely at cross-purposes. Some nontrivial fraction of men must choose between overall health—and sexual health in particular—and high-level physical performance. You can read about the experiences of others in this post. I would argue that your doses are above...

Here's an interim update on this research. It had become clear that if I wanted to continue using small-gauge needles, e.g. 31 gauge, then I needed to create an aqueous solution; the particle sizes in even partial suspensions were too large to get a predictable dose. A new formulation that...

There is a possible middle ground, which is topical finasteride, along with topical and/or oral minoxidil. I had unpleasant side effects from oral finasteride, and it took some time to make the connection and then recover. But as hair loss resumed I eventually gambled on going the topical route...

As the point-by-point rebuttal has gotten repetitive, I'll skip to this, which I agree is the crux of the matter. In the end you've provided no evidence that there are advantages to starting TRT with this higher, non-physiological dose. In contrast, I have shown that lower starting doses can be...

Trough levels on testosterone cypionate do tend to rise with a higher injection frequency—and variation decreases. A propionate blend given daily is a different animal. You would adjust the dose to give you an appropriate peak level, which you get within a few hours of the injection. The...

If you're sufficiently motivated then a logical progression in the experimentation is daily injections of a cypionate/propionate blend. Then you remove the variation across different days and you can focus on how each day should be. With a blend you can control how much daily variation you want...

I post this occasionally to remind people to be careful with making inferences from LH measurements. Overall there's going to be a correlation with testosterone. But with any single measurement you don't know where you are with respect to the pulses. Endogenous testosterone is going to be like a...

They are, but that should read "high starting dose". You added a "majority of men" qualifier. I'm not claiming to have quantified the rate at which men have problems at this dose. My point is that a midrange dose, say 50-80 mg TC/week, is less likely to cause side effects. While the general...

https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/209863Orig1s000SumR.pdf Nonetheless, it makes sense to titrate to the center of the healthy normal distribution for initial dosing. That's not a claim I have made, though it would undoubtedly be true if out-of-range free testosterone...

That's patently false. I called the 60-70% figure a rough guess initially and then provided the statistics to back it up, showing a more accurate number was only 5% outside of my estimated range. And speaking of prevarication, as long as we're letting AI do the heavy lifting for us: - However...

Some interesting stuff there, but I suspect it's far from complete. More discussion of testosterone's link to antisocial effects is needed. A small point, but I have to somewhat question the statement that "even modest increases in lethal cancer late in life would select against chronically...