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Urgent: Does anyone know if Metformin discontinuation can cause rebound hyperglycemia? I am not diabetic but since July, had been taking Metformin for anti-aging, cardiovascular and many of its other benefits, however, because it was tanking my testosterone levels to all-time lows (see my post...

1 month update - officially in the tank whether it's from Metformin or not. Latest labs as of 12/6 are confirmatory for secondary hypogonadism: TT: 347 FT: 48.2 BIO: 99.2 SHBG: 30 E2: 11 Again, main concerns with proceeding with TRT: Given my history of hypercoagulopathy (past clots in both...

A few doctors have touted the little-known thyroid hormone T2 to be used to help burn brown fat. Since there is only a tiny amount (8mg) in my NDT, I was thinking of adding it for the purported benefits...

https://www.peptidesciences.com/kisspeptin-10?queryID=330b154d45e02649aed60369fa245d8b&objectID=154&indexName=m1_default_products

Just came across this YT video:

I have a friend who's been on clomid and adex for several years and his T land E2 labs look great and he feels great. I just don't like the possible estrogenic aspect, but that hasn't seemed to be a problem for him, so, was thinking of giving enclomiphene a shot. If I did TE, I would be...

Due to my existing hypertension and past hypercoagulopathy, perhaps I would be best advised to try a SERM (i.e. enclomiphene) before jumping to frank TRT. Thoughts?

I am not T2D but prone to it, so unlike the test subjects, am taking Metformin electively as a geroprotective and prophylactic agent. The question is whether staying on it indefinitely will eventually necessitate TRT. I was already low normal and considering TRT [June, 2022 (pre-Metformin): TT...

What would be a "safe" low dose starting point for someone who has hypertension and past clotting issues, both of which are being managed by meds, exercise, diet? 20mg?

I posted my T labs above. I think it's pretty obvious Metformin had a sustained down-regulating effect on my levels. I will test again soon to see if it leveled off. How many others have seen their T levels plummet when on Metformin (on or off TRT)?

It definitely tanked my levels (see below) and I would advise the anyone who's not T2D be aware of this and perhaps not take it unless you're hormonally optimized (on TRT). June, 2022 (pre-Metformin): TT: 553; FT: 76.9 August, 2022 (1 month Metformin): TT: 415; FT: 70.2 November, 2022 (4 months...

My joint pains have worsened to which I attribute both low T and E2 symptoms. I think it's obvious I should d/c the Metformin until I get my hormones optimized.

My glucometer app does:

5-7 180lbs - but even when I weighed 20lbs less, my BP did not lessen. Have tested my DNA extensively for hereditary clotting issues and nothing came up except MTHFR. I feel I need be on TRT at this point and think I should d/c the Metformin for now until my T levels are optimized. Maybe start...