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I looked at metformin and sirolimus. Sirolimus (rapamycin) is not a direct substitute for metformin; they operate through different pathways, with sirolimus primarily being an immunosuppressant and anti-aging compound, while metformin manages blood sugar. While both have anti-aging potential...

So are you saying instead of metformin you are taking Sirolimus?

Interestingly, while metformin may limit the size of muscle gains, it does not appear to significantly impact the gain of muscle strength or power.

I would assume it's 3 months just like it takes 3 months for metformin to completely work.

Combination of tauroursodeoxycholic acid, co-enzyme Q10 and creatine demonstrates additive neuroprotective effects in-vitro models of Parkinson’s disease https://pmc.ncbi.nlm.nih.gov/articles/PMC11701167/

Metformin significantly raises shbg in man who aren't type 2 diabetic. In men who are type 2 diabetic it can lower shbg.

I take metformin ER 1500 mg daily. I've been on metformin for 13 years. The only side effect I've had, it lowered my vitamin B12. If I can get my a1c under 5, I'm going to stop metformin to see what kind shape I can get in.

Personally, I do not like gel testosterone. It was originally offered to me but I said no, I'm too concerned about contaminating my wife and grandkids. If you do decide on injections there's lots of good threads here. I would start with a really low dose. Maybe 70 mg of testosterone and I do...

Pectasol (modified citrus pectin) inhibits a protein called Galectin-3. A recently published paper says The pivotal role of Gal-3 in the aetiology of PD represents a promising therapeutic target for the development of future disease-modifying therapies. It’s significantly elevated in PD and...

This thread should really help you. https://www.excelmale.com/threads/semen-analysis-results-after-adding-fsh-to-trt-and-hcg.13612/

Personally I believe yes. High hematocrit (HCT) — defined for men as generally >50-52% — causes significant health issues by increasing blood viscosity (thickness), which restricts circulation and increases cardiovascular risks. Key issues include blood clots, stroke, heart attack, and...

https://www.excelmale.com/forum/threads/raising-ferritin-fast-a-how-to-not-a-question.24186/

https://www.alzdiscovery.org/cognitive-vitality/blog/testosterone-treatment-a-risky-bet

I'm sure you read it's for Parkinson's. Pretty tough illness.

https://gero.usc.edu/longevity-institute/supplementing-glycine-and-n-acetylcysteine-glynac-in-older-adults-benefits-both-health-span-and-lifespan/#:~:text=In%20summary%2C%20this%20RCT%20found,related%20diseases%20in%20the%20future.

Based on the study published in Parkinsonism & Related Disorders (2026), titled "N-Acetylcysteine is associated with changes in functional connectivity in patients with Parkinson's disease," here is a summary focusing on the specific improvements observed after treatment. Overview of the Study...

I've never take it any type of iron supplement. Even when I donated every 8 weeks, I never felt the need to add an iron supplement.

Anything that increases traffic and members. Is always beneficial. Plus I agree with badass about proper etiquette.

Calcified plaque is stable plaque. It takes one year for soft plaque to become calcified and become stable. Even though your arteries may have plaque, they can still adjust, with a catheterization they can't even see the plaque, they can see how open your arteries are. If your plaque grows at...

You can also eat less!

During my first 2 years of TRT I donated blood every 8 weeks. I would actually do it before I worked out, I'd like the way I felt after donating. Finally after 2 years my HCT stabilized and I never had to donate again. It's been over 11 years now since I donated blood. I never worried about my...

Promoting PSA Tests

Most people think Vitamin D is “just a vitamin" Most people think Vitamin D is “just a vitamin," and, indeed, it is a vitamin… but this chart shows it behaves more like a hormone (a feature of several vitamins) that controls hundreds of processes in your body. Sunlight hits your skin → your...

Naringin supplements can interfere with various medications by inhibiting enzymes like CYP3A4

Dopamine, thank you. Even at 71 sex feels unbelievably good.

I would say both. When I first started trt I had to donate blood every 8 weeks. When I went to daily injections I never had to donate again. My HCT has stayed in a good range for over 9 years.

I agree with whitemale. It's just a number, estrogen is very important for men to stay healthy.

It sounds like you have the perfect protocol for you. I would not change anything. It's great that you can have higher levels of estrogen and feel the good benefits.

The main benefit for me, no brain fog before TRT I did have brain fog. The only side effect I have is low amount of semen.

Yes, I still on TRT. I'm feeling perfect. 16 mg of testosterone cypionate daily, 500 iu of hcg every third day and no AI. Testosterone, Serum 1482 ng/dL range 264-916 Free Testosterone 24.5 ng/dL range 6.6 -18.1 DHT 61 ng/dL (no range on results) DHEA-Sulfate 260.0 H ug/dL range 30.9-295.6...

https://www.excelmale.com/threads/zinc.32289/post-297699