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"The golden mean, or golden middle way, is a philosophical concept, primarily associated with Aristotle's ethics, that emphasizes finding a virtuous middle ground between two extremes, one of excess and one of deficiency. It suggests that true virtue lies in moderation, avoiding both extremes in...

I ran some ChatGPT deep research on the behavioral effects of hCG-derived neurosteroids in men on TRT that you might find interesting. Behavioral Effects of hCG-Induced Neurosteroids in Men on TRT Context: In men undergoing testosterone replacement therapy (TRT), adjunctive human chorionic...

There is no longer any such thing as compounded hCG due to changing regulations. My impression is that most people these days are using Indian generic brands of hCG due to the drastically lower cost than pregnyl. The eutrig brand I'm using is a urine-derived hCG with a good reputation for potency.

I agree. If you are trying to minimize hematocrit increase with topical you'll want to apply only once daily in the morning. We see men applying in this manner reach > 1,000 ng/dL total T at the peak and yet still have detectable LH levels > 1 IU/L due to the overnight trough.

Treat sleep apnea, stop smoking if you do smoke, lose weight if you are overweight, improve insulin sensitivity if you are insulin resistant, increase cardio exercise. Your hormone levels are not high enough to produce excessive hematocrit in the absence of other contributing factors. I would...

I saw Bryan Johnson is taking 81 mg 3x weekly, which appears to be a compromise to gain some of the anti-cancer and CVD benefits without significantly increasing bleeding risk. I might do the same thing.

I'm going to try 2.5 mg orally again now that I'm old enough for it to make sense (almost 45). ChatGPT keeps telling me to try it for various reasons. Started today. I'll let you know how it turns out.

Everything old is new again. I'm still a little skeptical of DHEA and alot skeptical of pregnenolone as enhancements to TRT protocols. Based on what I've seen, I would rank the odds that a man on TRT sees net benefit with these compounds as hCG > DHEA > Pregnenolone (distant third)...

A couple of you challenged his attribution of symptoms to estrogen. He took anastrozole and his anxiety and light-headness disappeared: not once, but many times. This is how someone can confidently and accurately attribute a symptom to excess estrogen. I would never suggest ongoing use of an AI...

Yeah, sounds like the problem is more estrogen than you can handle (this is almost always the problem). I had my absolute worst results on TRT, and a personal record for lowest T/E2 ratio injecting in that exact location. I would urge you to experiment with injecting in the ventroglutes or...

Free T is 23.6 ng/dL, pretty reasonable. E2 is on the high side at 39.6 pg/mL given the lower 18.8 nmol/L SHBG. IGF-1 is elevated by TRT via aromatization to E2, so this will drop if you get your E2 down a bit. IGF-1 is also driven higher by insulin, which you can bring down by cutting carbs...

Sweet baby Jesus, that is an absurdly high trough if I ever saw one!

I will take him seriously on this when he posts his labs and they are not also found to be "absurdly high". I am reminded of the closeted gay congressman that publicly rails against homosexuality until they are caught in a men's room sex act.

I mean subcutaneous injections work well for 60-70% of men who try them: As I stated earlier, you would begin with IM if you wanted to maximize your odds of success right out of the gate.