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Also, depending on what dimension you need/want further improvement on, there may be approaches other than more T to achieve what you need.

Yes, donating blood will briefly lower HCT, however there are other benefits, the primary one being prevention of iron overload. The is some mechanism by which long runs apparently lower iron, however other than that, bleeding of some form and chelation, there is no way to get rid of iron, and...

As someone who's had some unexplained variation in test numbers myself, there's something to be said for staying on a protocol for while that in theory should work, and then seeing how your numbers align over a few measurements. My HCT was elevated and then dropped right back down after a while...

Three more random thoughts that occurred to me... - You might want to have one of the hair analysis tests done that measure mineral status. They're fairly cheap and might give you hint at an issue - If you have access to a sauna at your gym it is worth trying since sweating is one of the body's...

Something else you might try is just to stop altogether for about 10-15 days. If things dramatically improve at some point during that time, that would be a clue that your sweet spot is somewhere lower and you can restart at a lower dose. In my early days of TRT I used to come off for a couple...

IMO, if you are in a generally good place, I would stay where you are for a while and see if your e2 improves over time. It's hard enough to get symptoms sorted out, let alone trying to optimize numbers as well. It's impossible for me to tell if the brief supplemental e2 possibly reset my...

I've had issues with unexplainably low E2 as well but it seemed to resolve after a while and rose to more normal levels (a while being a year or so). A lot of things I wouldn't have expected can interfere with the aromatase enzyme, such as zinc, so you might want to review you supplements and...

How about starting a thread dedicated to whatever it is you're arguing about and leave this and other threads to the specifics of the OP's topic. This has become like bar fight that spills out of one bar and goes up and down the street into other bars. My contribution to that thread would be...

It's way more nuanced. Some compounds, specifically Anadrol, are well-known to make people look red. There are plenty of people who likely have high-blood pressure. The "dry" look of thin subQ fat layer can make some people look red. Boldenone can raise HCT. and increase vascularity. But the...

There are other options. What issues are you looking for the TRT to resolve?

For results that extreme, my approach is to immediately test again if possible and assuming no symptoms. I had elevated HCT for a while and I can say that it is essential that you be fully hydrated to get an accurate test. I would schedule your tests late morning and drink at least half a gallon...

First, IMO, there are many things you need to explore before going on external T. It is nowhere near as simple as many make it out to be. Since your sexual function is still fairly good, I would be doubly cautious because, as many men have reported, TRT can mess that up and not have it resolve...

Sparky's comments remind me that intestinal permeability (leaky gut) could be at play here too. There are tests for that (LPS?) but it seems better to just follow a protocol that would cure/prevent the leaky gut, such as Dr. Gundry's Gut Check protocol.

In general, poor health is accompanied by a decline in Nitric Oxide production. The Viagra class of drugs blocks an enzyme that breaks down nitric oxide so it indirectly increases Nitric Oxide if someone is producing good amounts in the first place. Dr. Kendrick points out that these drugs far...

I do too many things to list but I made a very quick starter list below. While the book has as section on specific recommendations which, for example, caused me to start niacin again and measure LP(a) and homocysteine, the bigger impact for me was that by better understanding mechanisms of harm...

Taking magnesium, K2 and vitamins A, K and E (full spectrum) may help absorption, but that sounds strange. Some infections "hijack" vitamin D, but I really just don't know. You might look into Chris Masterjohn's writing on the topic particularly around interaction with the parathyroid hormone.

Some comments in no particular order. - Your Vitamin D reminds me that there are apparently some infections that use the Vitamin D receptor as an entryway into cells, and for those infections Vitamin D can make actually make things worse. Dr. Michael Ruscio (who you should also look into) did a...

I agree with everything Funk said. Regarding mold, which I forgot to mention. I think what you want is a test that determines if you have been exposed and have some sort of damage from it. You could have been exposed elsewhere. A doc who specializes in that type of thing would be good to...

I really admire the creativity here, but I'm puzzled by using crushed tadalafil. Since you're basically (potentially, dependent on absorption) injecting the fillerr and binders, I would think there could be a risk there if those are things that are not absorbed in the digestive tract when taken...

Your symptoms scream chronic fatigue syndrome and hopefully someone here with experience on that topic will chime in (possibly @FunkOdyssey ?) which if IIRC can be from chronic infections and/or micronutrient deficiencies. From what I've heard, mainstream doctors are fairly awful at resolving...

This is another reason I am not a fan of ChatGPT. First, the point of the book is to propose a model of heart disease which actually fits the data we have about CVD. While there are a number of recommendations in the book. the bigger picture is that there are literally hundreds of risk...

It's puzzling that, at least based on the notes, he doesn't say anything about strengthening the innate immune system, specifically with Vitamins and minerals like D, C, and Zinc. Supplements like Beta Glucans apparently help as well.

DHM (dihydromyricetin) is an amazing compound and among other things aids in metabolizing alcohol.

While I would never recommend drinking in large amounts, or in any amount for someone who does not have a good relationship with alcohol, there are three big problems with the anti-alcohol push. First, the observational studies have grouped heavy drinkers in with light social drinkers. I have...

This would imply that the DHT Enanthate is at risk as well if there is no longer any source for raws.

I will be curious to hear if you are able to maintain healthy e2 level with that protocol. Also, I'm glad to see TNE becoming the standard term for straight testosterone again. Alternate terms like native T just create confusion IMO.

I didn't watch the video, but my understanding from other sources is that while technically plant protein can, in the right combination, approach animal sources, in the real world you would have to eat so much of it that it is both impractical, and what plant protein comes bundled with could be...

Peptide sciences is the trusted go-to, but I have had very good results with the patches from Phase4 (formerly Ageforce) and I find them very easy to put where ever I'm having an issue.

That sounds somewhat like what I had which I think was Cubital Tunnel Syndrome. In my case it was the nerve that goes past the funny bone in your elbow becoming irritated and out of place. As with all joint injuries, use very light weights to get blood flow through the area at least once a day...

This the key IMO. There is no substitute for self-education, and as I've pointed out many times, the body is a highly interconnected set of systems, and a lot of urologists and clinics are likely jumping straight to hormone-centric treatments when the underlying issue is something else like...

It's worth noting that the body's need for Vitamin C rises massively when fighting an infection since Vitamin C is kind of like the body's version of "ammunition" for the immune system "gun". Also, it's almost impossible for most people to maintain D levels above 50 (where the evidence seems to...