Search results

As long as we're fantasizing that someone's going to fund such a study then of course it should include enough samples to generate accurate AUCs. But first, if you're rejecting the explanation involving injection site leakage then you should come up with a remotely plausible alternative...

Have to re-emphasize: "Clinical data consistently shows that SC administration of testosterone esters achieves comparable bioavailability to IM." Under controlled conditions the bioavailability is the same. What you're left with are basically three things: • Localized side effects. Ok, some...

Query to Grok: Someone asserts that testosterone esters have less bioavailability when delivered subcutaneously (SC) versus intra-muscularly (IM). I disagree, pointing to Xyosted clinical trials that show similar areas-under-the-curves. He then points to a study showing that hCG does have less...

If you stop there one might think that elevated prolactin equals more dopamine activity. Nope. Modestly high levels of prolactin can reduce dopamine activity in men. Prolactin and dopamine have an inverse relationship in the brain, primarily regulated through the hypothalamic-pituitary axis...

Let's keep this in perspective: The lab measurement error is probably around the same size as or greater than the daily variation you see in levels. It's not something to even think about unless you shift to less frequent injections.

Your lack of understanding suggests either a problem with reading comprehension or else deliberate trolling. I've never said anything like that and yet here you are with a third admonishment in a two week period. The point is that with the long half-life of cypionate—actually more like five...

This is unnecessary. Men on daily cypionate will usually not see much variation.

Prolactin works against dopamine, so it can contribute to the symptoms you describe. According to Dr. Saya, and also in my experience, in some men even prolactin over 10 ng/mL can cause issues. Perhaps it depends on the level that's appropriate for the individual's physiology. There's a simple...

Interesting that we used almost identical numbers to test this. I had SHBG of 40 and 27 nMol/L, FT of 13.6 and 13.1 respectively, the latter well within margins of error. Of course I also searched for the full text, but so far even the abstract only shows up on this page. It would be...

That doctor is way too pessimistic. The studies suggest that a significant majority of men can regain fertility. It can take as long as one or two years, however. If you're wanting to hang onto the cypionate as long as possible then you might be interested in this speculative treatment...

This study should not be used to suggest that subcutaneous administration is less effective than intramuscular. First, free testosterone would be the more definitive measurement, and that was not used. Second, there's no mention of dosing. Then there's the hint of bias in the total testosterone...

To further elaborate on the low-and-slow philosophy: The key thing is to establish a solid reference point at reasonable levels, which is where you are now. Later on, if you think improvements are possible then you will have a point of comparison as you gradually raise the dose. It's common to...

I agree with @Seagal: Those are stellar numbers for just starting out, right in the midrange for healthy young men. Do give it some more time. If you haven't already, skim through this article to get a sense of the time frames for various improvements. Remember that TRT is not a cure-all, and...

I will continue to advise newcomers coming to this site with problems that a low-and-slow approach is preferred, backed up by scientific and anecdotal evidence. If you're going to keep butting in with contrary and harmful advice that is unsupported by any serious evidence then you can expect...

You can repeat this misinformation forever, but the study does not compare physiological to non-physiological doses, and therefore does not support your claim. The fact that a particular dose is tolerated in a short-term dose-response study does not indicate that it is suitable for long-term...

Which works in this fantasy world of yours where you can only choose between 125 mg/week and 50 mg/week in one dose. As I implied, there's plenty of evidence that physiological doses are safe and effective. It's up to you to prove that non-physiological doses are better, especially because you...

I wouldn't expect enanthate to be much different from cypionate on similar dosing schedules. But it's perhaps harder to evaluate propionate if you're not measuring area-under-the-curve. Are you saying your E2/T ratio was the same? The limited propionate data I have also doesn't really support...

Just putting this out for discussion and comments. There have long been anecdotal suggestions that faster-acting testosterone leads to lower overall levels of estradiol. In particular, it's often claimed in regard to using testosterone propionate versus longer esters such as cypionate. It could...

Ask yourself why we even have reference ranges. They are used to diagnose and treat disease/dysfunction. The dysfunction is clearly associated with levels above or below the range. I hope you aren't claiming otherwise. For all the supporting studies you claim to have, all you can do is return...

Really good advice here. Going from TC once every two weeks to TU is like going to the opposite end of the spectrum. You currently have this enormous variation in serum testosterone over each two-week cycle, with troughs being something like 10-20% of peaks, and peaks likely over 1,000 ng/dL...

It's refreshing to see some marginally clever pushback interspersed with the usual inanities. Unfortunately it falls short, because fitness is good.

The burden of proof clearly is on you with the extraordinary claim that non-physiological levels are better for overall health and should be the default starting point for TRT. As I went through your list of references it became clear that you had not read them and were relying on a faulty AI...

In real life men thrive on physiological levels of testosterone. Think the current president @ 441 ng/dL. On TRT some men get away with higher levels, while others suffer side effects and come here, as you well know. What would I do without your incredible wisdom? Maybe I should eat right and...

I'm not sure what you're referring to. I don't recall even expressing an opinion on the prevalence of this side effect. I did tell you that TRT had the opposite effect on me, with higher doses being somewhat sedating and demotivating. The side effects of excessive testosterone that I've...

I'm not saying this applies to you, but I went down the thyroid rabbit hole with Defy and now think it's a case of treating the side effects without looking into the underlying cause. I had top-of-range reverse T3, which they treated with a T3 prescription. It brought down rT3, but didn't seem...

How quickly they forget. After this point-by-point examination of your references you didn't even attempt a response. https://www.excelmale.com/threads/trt-other-medications.32780/post-300919 All this study shows is that being hypogonadal is somewhat worse than being mildly hypergonadal...

If you recall, I dismantled every one of your purported references. Not one refuted my claims. You basically relied on one study in which no subjects experienced physiological levels of testosterone throughout each injection cycle. Meanwhile, you continue to defend the indefensible: that a...

It's important to have a good idea of free testosterone. Many of the existing tests are inaccurate and even use different scales. Which lab and which test did you use to obtain that figure of 63? What is the normal range? Going by total testosterone alone, TRT would be inadvisable. Also, if...

Low SHBG is associated with metabolic syndrome, but it doesn't seem to be an issue in your case. Anecdotally, it appears that men with low SHBG are more likely to have difficulties with TRT. There's also some speculation that low SHBG might impair androgen signaling by reducing the intracellular...

Use this site for Vermeulen free T. With TT of 45.2 nMol/L, SHBG of 37.8 nMol/L and albumin at 4.38 g/dL you get cFTV of 1.08 nMol/L, which is over 31 ng/dL. The top of the normal range for this is in the low 20s. In line with what @FunkOdyssey said, your peak level could easily be two or three...

While percent free testosterone is not a very useful number in general, that figure of 2.3% is suggesting that your pre-TRT free testosterone was around 11 ng/dL. Is this correct? If that was obtained by equilibrium dialysis then it's not a particularly low number. Your current high free...