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https://journals.physiology.org/doi/full/10.1152/japplphysiol.00276.2025

This comment was financially supported by The FunkOdyssey Makeover Clinic

I should have written that this comment is not related to your discussion (more to Vince's post and in general there is often a bias towards physique). I was amazed how long you both discussed in a civilized manner. Bravo Yes, I think to know that there is dose relation to symptom relief...

Yes, a personalized approach. If we look at the normal distribution and taking TRT literally, I agree with @Cataceous though. The aim of TRT isn't 'supraphysiological' muscle growth.

Interesting

I disliked the misinformation and outcasting and making feel people guilty if they considered not taking a COVID vaccination.

Any reason YOU (18yrs) would need to take any of these drugs?

Would then only change one variable, i.e. reduction of the dose from 60 to 50.

Did you feel any different with twice per week injections?

", I still have the phenomenon a feeling sort of bad the day after the injection and always feeling the best to wear the end of the week. " Yes, it makes sense to me to split and to reduce your dose. And you could try testosterone undecanoate. Once per week injections give very stable levels.

https://www.midwesterndoctor.com/p/we-now-have-proof-the-covid-vaccines

Being now on TRT, you could try losing bodyfat without additional drugs. TRT should make it easier keeping muscles while dieting.

Great, could you please send me a kit :) Here minimum 85€ for 5mg

"Increased joint pain in prone sites of tendinopathy (shoulders, elbows)." Did your strength and workload increase (faster) since adding TRT?

"The biggest benefits I’ve seen are I have lost about 12 pounds, but the weight loss has plateaued over the last month. I’ve also seen really good body composition changes for it only being two months, as I am lifting weights 3 to 4 days a week." "My libido has not been very good, and I am...

I think that if one applies the cream twice daily, keeping levels stable that it will raise hct almost as high as with injections when the accumulated T dose is comparable.

What was your TT or fT on this 42mg TC per week? Hope the cream works for you wrt not raising hct (too much).

I would consider anything above the age related reference range supra physiological. If my age-related max TT is 750, and I have a constant level of 750, that's also supraphys

Bone microstructure matters https://pubmed.ncbi.nlm.nih.gov/19783591/ https://open.oregonstate.education/aandp/chapter/6-3-bone-structure/

It can be a medication in high doses for bipolar. Here in this context it's about supplementing single digit mg (about 1mg). We have various small amounts in our water etc. So far lithium is not regarded essential but there is academic discussion about it and whether a small amount is...

I'm sitting in the EU (Germany) thus I was lucky to find it on Amazon labelled for lab and research purposes.

In case someone is interested, there is an older thread with links to information: Thread 'Lithium Orotate 5mg ?' Lithium Orotate 5mg ? - Excel Male TRT Forum I find this YouTube video provides an objective brief overview with relevant details:

I didn't read in depth about it and started taking 0.25mg Li orotate (liquid) in the morning. I felt like it makes me a bit tired. I then read up on potential biochemical effects and the potential GABAergic effect made sense. Now taking it in the evening. Did any of you with tendency to...

I'm interested in hearing about your experience with supplementing Lithium (orotate, aspartate etc). Any feedback is appreciated.

Any dose of AAS other than testosterone is supraphysiological.... This review is terrible... "However, when testosterone is used in supraphysiological doses and without medical supervision, a number of risks arise." vs the studies that are referenced Imo it should have not been published and...

If you need to use an AI. Start low and increase slowly. You don't need to measure it in that process, you can go by symptoms. Once your symptoms resolved and it's stable, then you could measure E2 for reference.

What are your symptoms of too high E2?

Salvia test

Leflutrozole in male obesity-associated hypogonadotropic hypogonadism: Ph 2b double-blind randomised controlled trial T Hugh Jones et al. Eur J Endocrinol. 2023. https://pubmed.ncbi.nlm.nih.gov/37579053/

DeepSeek Answer: Based on your results, your labs are **overall very good for a 54-year-old man**, with no major red flags. However, your testosterone level (506 ng/dL) falls within the "normal" range but is **on the lower end for your age group**, which *could* be a contributing factor to your...