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Defy Medical TRT clinic doctor
  1. FunkOdyssey

    Advice on next steps - mid-low free T

    I've actually been on test cyp for the last couple months and it's working fine for me. 35 mg EOD.
  2. FunkOdyssey

    Help with blood test results and erectile dysfunction

    Ran into this article today on CGM benefits in early type 2 diabetes (see attached).
  3. FunkOdyssey

    Help with blood test results and erectile dysfunction

    Great suggestions from Guided above. The Clot Thickens is a must read. Chromium can be effective, but can also cause major insomnia in some; watch for that. Time restricted eating, definitely. Avoid seed oils, definitely. Absolutely agree. He actually provided a fasting insulin level in his...
  4. FunkOdyssey

    Advice on next steps - mid-low free T

    In my opinion, it's more helpful to think about specific target levels, independent of reference ranges, which vary widely from lab to lab. You'll test total testosterone, and you'll need it (together with SHBG) to calculate free testosterone, but free testosterone is where the rubber meets the...
  5. FunkOdyssey

    Advice on next steps - mid-low free T

    The following review discusses the findings of over 20 studies that investigated the effects of TRT on cognition, in both healthy men, and men with Alzheimer's or other forms of cognitive decline. We might expect worsened cognition if the lack of GnRH is impactful, or an acceleration of...
  6. FunkOdyssey

    Advice on next steps - mid-low free T

    It sounds reasonable, and might be helpful in some cases.
  7. FunkOdyssey

    Advice on next steps - mid-low free T

    One more thought I had about GnRH: humans pre-puberty have little/no GnRH secretion, and with varying age of puberty, some will have spent more or less years of their life in this low GnRH state. If the absence of GnRH is harmful then, we might expect later puberty to correlate with increased...
  8. FunkOdyssey

    Advice on next steps - mid-low free T

    Testosterone with no ester attached.
  9. FunkOdyssey

    Advice on next steps - mid-low free T

    GnRH has neuroprotective and anti-aging effects in mice. However, studies of men on TRT with suppressed GnRH do not show higher rates of dementia, nor do they show higher rates of all cause mortality. If the lack of GnRH is having negative effects then, it's either too subtle to affect health...
  10. FunkOdyssey

    Advice on next steps - mid-low free T

    Compounded bioidentical / native testosterone in a lipid-based delivery vehicle, similar in that respect to Kyzatrex and the other oral TU products. The bioidentical testosterone is better tolerated than TU with fewer gastrointestinal side effects, and appears to be less suppressive of the HPT...
  11. FunkOdyssey

    Advice on next steps - mid-low free T

    In the kyzatrex trial I mentioned, they started at 7 ng/dL free T and increased by 7 ng/dL to 14 ng/dL with the 200 mg bid dose. I would be looking to create a dramatic difference from your 10 ng/dL baseline with this experiment to ensure the results are noticeable, and targeting something more...
  12. FunkOdyssey

    Advice on next steps - mid-low free T

    hCG will only complicate things - I would leave that out (at least initially). I work for Maximus so my bias is towards our oral testosterone, but with Kyzatrex, you will need much higher doses than 100 mg to move the needle. 200 mg bid only produced 14 ng/dL free T in their phase 3 trial. You'd...
  13. FunkOdyssey

    Advice on next steps - mid-low free T

    Just curious: how did you manage to have four kids by age 30, having been in med school and residency the entire time? I feel like there's a story there.
  14. FunkOdyssey

    Advice on next steps - mid-low free T

    I'll give you my less conservative perspective. Yes, I would experiment with increasing T levels, given your symptoms, which would produce a positive result on the ADAM questionnaire. Your levels, while not low, are not high enough to rule out the possibility that more T could improve the...
  15. FunkOdyssey

    Advice on next steps - mid-low free T

    We have data showing no statistically significant suppression with once daily oral testosterone at Maximus which will be published soon on the website. The shorter half-life of bioidentical oral testosterone vs. testosterone undecanoate is likely responsible. Please see attached excerpts.
  16. FunkOdyssey

    Testosterone dropped after a few months on the same dose

    I don't have a trough level for my current protocol, but I took a midpoint level of 1230 ng/dL total, 28 ng/dL free, 30 pg/mL e2. This was on 35 mg test cyp EOD, and I took labs afternoon of the day after injection.
  17. FunkOdyssey

    Testosterone dropped after a few months on the same dose

    I'd be going alot higher with these labs. There's being careful, there's being very careful, and then there's just straight up wasting time. Straight to 100 mg if it were me, at least.
  18. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    They suggest 25-50 mg a week, because above 50 mg it supposedly causes paradoxical estrogenic effects via conversion to 3b-androstanediol.
  19. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    No, that looks amazing. So expensive though, wtf.
  20. FunkOdyssey

    Any Testosterone Propionate Compounding Pharmacies left?

    Most people who are still using test prop have been forced to switch to UGL suppliers.
  21. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

  22. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    Which alternative source for topical DHT do you suggest? There aren't exactly a plethora of options. That's the only product I'm aware of that has reliably worked for everyone who used it (including myself and RL friends). 100% DMSO would explain the skin rape though.
  23. FunkOdyssey

    Help with blood test results and erectile dysfunction

    If continuous glucose monitors are available over-the-counter where you live, you should wear one for some time. If they aren't available OTC, see if your doctor will prescribe one for you. The minute to minute biofeedback on your glucose levels is invaluable for someone seeking to improve their...
  24. FunkOdyssey

    Blood test feedback (incl before, during, after KETO - impressive results)

    If you liked the results of keto but not the effort involved, I would suggest carnivore is much easier. Twice a day, I throw a salted piece of meat into an air fryer. It cooks for 10-15 min, I put it on a plate, add some fat to correct protein/fat ratio if necessary, done. Perfect metabolic...
  25. FunkOdyssey

    Where to get Enanthate 100mg/ml?

    New doctor (either local or telemedicine TRT clinic) or go UGL.
  26. FunkOdyssey

    Everything in range except E2 and LH almost at upper limit

    Yes, 100% do this. I missed this in the initial post.
  27. FunkOdyssey

    Help with blood test results and erectile dysfunction

    This is the type of lower fat, high refined carb, pseudo-healthy diet that most Americans are eating, resulting in 50% of the population being either prediabetic or diabetic. This is the direction you are also heading, unless you make significant course corrections. The ED you are dealing with...
  28. FunkOdyssey

    Help with blood test results and erectile dysfunction

    I think you are focused too narrowly on the particulars of your protocol and need to investigate the root cause of your excessive aromatization. Your HDL and triglycerides are abysmal and suggest serious metabolic dysfunction. Insulin strongly promotes the expression of aromatase enzyme. Excess...
  29. FunkOdyssey

    Everything in range except E2 and LH almost at upper limit

    Looks like hypogonadal estradiol, which aligns with your symptoms, and which would cause the pituitary to release more LH as it tries to raise estadiol. Testosterone is actually pretty good, but you aren't aromatizing enough. If you want to stay natural and just do something OTC to bump up E2...
  30. FunkOdyssey

    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    Skin becomes inflamed, feels irritated to the touch and breaks out with acne. Fasting glucose, fasting insulin, HbA1c, lipid panel (watch triglyceride:HDL ratio), uric acid (driven up by fructose, both a marker for and cause of metabolic dysfunction), and ALT / AST / GGT (screen for liver harm...
  31. FunkOdyssey

    Any advice?

    That is overcomplicating things - there is no need. Any change in the T/E2 ratio that occurs when you reduce dose will be minor and very temporary. You'll just throw everything more out of wack by introducing an AI.
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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