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Debate about the Free Testosterone Hypothesis: Useful Tool or Misguided Mirage?
Dr. Anawalt won handily. Dr. Handelman's fixation on difficulties with measuring free testosterone did nothing to dispute the validity of the free hormone hypothesis. He had no answer to the numerous human epidemiologic studies which support it.- FunkOdyssey
- Post #7
- Forum: Testosterone and Men's Health Articles
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Experiences and Questions: Personal Experiments with Oral Native Testosterone Base & Enclomiphene (TRT+), Testosterone Propionate, HCG and more
Yes, but the negative feedback from oral native testosterone is minimal to begin with. We have internal data showing, on average, men's LH only dropped by 0.8 IU/L (non-significant and within margin of error) when using a single 600 mg dose of native oral T daily. Yes, it certainly is, unless...- FunkOdyssey
- Post #5
- Forum: Blood Test Discussion
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Building a TRT protocol around hCG
Very interesting result with the test suspension results. I think there are a percentage of men that do maintain long-term libido on testosterone alone, another group that maintains it long-term with hCG, and I would imagine the fraction that cannot maintain libido despite the combination is...- FunkOdyssey
- Post #7
- Forum: When TRT Is Not Enough (ED, Libido, & More)
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Thyroid , would boosting T4 help anything
Mine is also like this (lower end FT4, midrange FT3) and past experiments with supplementing thyroid hormone only made me feel worse. Knowing what I know now, I never would have messed with it at all.- FunkOdyssey
- Post #9
- Forum: Blood Test Discussion
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Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week
These are not good. You are right on the line of metabolic syndrome with these values (HDL <= 40 and Triglycerides >= 150 is the cutoff), and the Trig/HDL ratio of 3.4 is associated with significantly elevated CVD risk, regardless of your LDL. We had a great discussion on this in a recent...- FunkOdyssey
- Post #12
- Forum: Testosterone Side Effect Management
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Thyroid , would boosting T4 help anything
This, because free T3 is what matters. It would be analogous to supplementing testosterone when your total testosterone is on the low side, even though your free testosterone was at a good level. You don't want high or "optimal" levels of thyroid hormone either - this is associated with a...- FunkOdyssey
- Post #5
- Forum: Blood Test Discussion
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Pharmacokinetic Profile of Testosterone Suspension: A Case Study
I love that you did this experiment and wrote up all of the details for us. Very puzzling results though!- FunkOdyssey
- Post #2
- Forum: Testosterone Basics & Questions
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Building a TRT protocol around hCG
Cortex released a video on this concept of using hCG and DHEA as the foundation of a protocol and then tailoring testosterone dose around that: I have kept going back and forth with hCG myself. I've noticed, now that I have some Janoshik-verified potent hCG (eutrig), if I take 250 iu EOD...- FunkOdyssey
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- hcg
- Replies: 62
- Forum: When TRT Is Not Enough (ED, Libido, & More)
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Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week
Fasting insulin and lipid panel (HDL and triglycerides specifically). Many of us had sleep issues in the beginning, and water retention is pretty much a given. Most or all of the water retention disappears eventually as you adapt to the new levels. You will certainly be able to find a dose...- FunkOdyssey
- Post #10
- Forum: Testosterone Side Effect Management
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Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week
That's your fasting glucose, not fasting insulin. You want to see your fasting insulin to determine whether you have insulin resistance. Your lipid panel has some big clues also, between HDL, triglycerides, and their ratio. Insulin resistant men often have a rough time on TRT. They aromatize...- FunkOdyssey
- Post #6
- Forum: Testosterone Side Effect Management
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Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week
Do you recall what it was?- FunkOdyssey
- Post #4
- Forum: Testosterone Side Effect Management
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Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week
These free T numbers you are reporting are bogus - likely labcorp direct free T if I had to guess. Your real free T (vermeulen calculation) with 100 mg was 21.8 ng/dL assuming 4.3 albumin, which is a very reasonable level for men on TRT. You have a high SHBG, so this reasonable free T is...- FunkOdyssey
- Post #2
- Forum: Testosterone Side Effect Management
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Advice on next steps - mid-low free T
True, but importantly, there's not even a hint in these 20+ studies that looked at effects of TRT on cognition that the lack of GnRH is causing cognitive deficits either. Some trends in that direction would be very persuasive in terms of convincing me to take this GnRH issue seriously. There...- FunkOdyssey
- Post #39
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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Experiences and Questions: Personal Experiments with Oral Native Testosterone Base & Enclomiphene (TRT+), Testosterone Propionate, HCG and more
This is quite plausible. Your absolute level of E2 is low, the ratio of T & DHT / E2 is very high, and you have enclomiphene antagonizing estrogen receptors on top of that. I would rather take less of something in this situation than add another compound to increase estradiol. Reducing the...- FunkOdyssey
- Post #2
- Forum: Blood Test Discussion
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