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Defy Medical TRT clinic doctor
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    Trans scrotal testosterone cream application is a game changer

    Dammit. I hadn’t thought this through, apparently. @RobRoy, in my situation assuming I want cream to be my primary TRT modality, but also need to raise my E2 levels (still a debatable concept), would you simply add testosterone injections? I’m still evaluating past labs and current labs, but...
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    Testosterone Cypionate vs Enanthate Ester break down

    What kind of doses are you doing EOD?
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    Trans scrotal testosterone cream application is a game changer

    Anecdote: I posted recently about getting labs while feeling shitty on cream. Still waiting on some results, but so far, labs demonstrate modestly, elevated DHT (99) and moderately low estradiol. For the first time in my TRT journey, I am contemplating that some of my negative experiences could...
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    Trans scrotal testosterone cream application is a game changer

    I think this concept is a slippery slope that we throw around here. While some of the technical observations may be correct that DHT is regulated at the cellular level and serum levels don’t matter, one can argue that this is a very common phenomenon, and none of the stuff we measure in the...
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    Testosterone Cypionate vs Enanthate Ester break down

    Awesome. I want the lizard, too!
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    Testosterone Cypionate vs Enanthate Ester break down

    Oh, and I forgot to follow up on my post above. I tried the MCT injections for a few days. Obviously, it's a very short time, but I noticed the same issues I did with other injections: headache and crappy feeling. So, I am inclined to say my issue is not the oil. That's not to say that some oils...
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    Testosterone Cypionate vs Enanthate Ester break down

    @FunkOdyssey, from what I understand, Hikma is the actual manufacturer, but it is sold under various brands. Which brand do you have?
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    Testosterone Cypionate vs Enanthate Ester break down

    Wow. This is great stuff. Please keep us informed. I think this stuff really matters (excipients and preservatives) to some that are sensitive.
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    Trans scrotal testosterone cream application is a game changer

    I found a way to get in touch with them this morning and made sure they added it. You are correct. Fortunately, I didn't wait too much longer. Edit: it was not included in the ordered labs. Thankfully, they were able to add it.
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    Trans scrotal testosterone cream application is a game changer

    Not mental for me, brother. Trust me. I got labs for the opposite reason - not because I felt good, but because I felt terrible.
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    Trans scrotal testosterone cream application is a game changer

    Crazy - I just thought of that same phrase the other day when I was thinking about how I felt: Wired but tired. In my case, I was on cream. I am waiting for labs I got drawn the other. I'll post if there is anything meaningful in them. But, and this is a huge BUT, it appears that quest may have...
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    Trans scrotal testosterone cream application is a game changer

    At some point, you may also consider getting a Xyosted pen and trying that.
  13. F

    Trans scrotal testosterone cream application is a game changer

    So, do you just have your provider call prescription to a pharmacy that sells it? How do you get your hands on it?
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    Trans scrotal testosterone cream application is a game changer

    @FunkOdyssey, now you’re talking my language! Where are you going to get this? I’d love to know. Only source I know of is Xyosted, which I have.
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    For Those That Get Headaches on TRT

    Interesting. I’m sorry to hear it, man. I feel you. One fun side effect of riboflavin is atomic yellow pee. It’s always fun to see!
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    Imaging-Guided Interventions for Knee Pain Relief: New Alternatives for Chronic Pain

    I will have to take a closer look, but many studies show, absolute superior accuracy with ultrasound, and/or fluoroscopic guidance for injections. However, oddly, efficacy is similar with and without guidance in numerous studies, despite the improved accuracy.
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    For Those That Get Headaches on TRT

    I actually have a bit of a blind spot when it comes to the relationship between iron and TRT (besides knowing that TRT stimulates erythropoiesis). @Systemlord and @FunkOdyssey, can you guys gimme a place to start reading? Cliff Notes version? I have pulled a few articles, but they are pretty...
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    For Those That Get Headaches on TRT

    Yep. My two theories: Fatigue is from ultra high levels at their peak (T, DHT or E2). Or, it could be the opposite, which is such a mindF**K. It could be the drop in levels after the peak. Interesting thought on iron. I never really give it much thought (at least not as much as our good friend...
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    For Those That Get Headaches on TRT

    These are all excellent points. Agree on tyramine - likely the issue rather than histamine (alcohol jacks me up, too). A long time ago, I did an elimination diet (not specifically low tyramine), but don't recall what I learned. For the last number of years, I have been fairly low carb...
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    For Those That Get Headaches on TRT

    I agree. I may try it in the next few days. Trying to decide if I should take Benadryl right away or wait an hour or two. Either way, I will probably give it a try.
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    For Those That Get Headaches on TRT

    It's mostly correct. In theory, I am fine using cream. But, it has been a bit of a difficult pony to tame. Results have been really inconsistent. At times I feel supraphysiologic. But, more bothersome than that has been recurrent severe fatigue. I think I posted about the fatigue elsewhere. I...
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    For Those That Get Headaches on TRT

    Anyone around here that has read any of my posts knows that the biggest thing that stands between me and achieving therapeutic HRT benefit is headache. @sammmy, or anyone else that has contemplated headache, what are your thoughts on histamine as a potential cause or contributory factor? I have...
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    Trans scrotal testosterone cream application is a game changer

    @TLR, are the numbers above you quote all with scrotal application? I had crazy numbers with scrotal application. I have since rotated dose and site (lower scrotal dose; combo of scrotal and extremity; extremity only). Anecdotally, I think my shoulders absorb well and upper inner thigh does not...
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    Trans scrotal testosterone cream application is a game changer

    You are probably correct. But, I also wonder if one's tendency to absorb can change over time. Another untested theory.
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    Trans scrotal testosterone cream application is a game changer

    Good question and it's exactly what I need to do. Only reason I have not is I want labs after I have been doing the exact same protocol for several weeks. I tend to make small modifications more frequently than I should. Guilty as charged.
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    Trans scrotal testosterone cream application is a game changer

    @RobRoy, that's a fair point. But, here I am getting ready to ask another question! I think you mentioned way back in the thread (or maybe I read this somewhere else), there is an occasional guy who needs TID dosing. How common is this? Rare? I ask because I have been using cream for several...
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    Testosterone Cypionate vs Enanthate Ester break down

    I think this may be true. I feel log dog shit after injecting. I have systematically tried to isolate what variable is causing it. My next test is to try to get MCT oil compounded test to compare to seed oils, but I am having a helluva time getting South Lake to fill the Rx. Meanwhile, sadly...
  28. F

    Empower text cream changed formula??

    Following up on this. My Empower cream consistency is similar to prior batches, but I just got a batch that I strongly suspect is substantially weaker than prior batches. I have felt really shitty lately, and realized it corresponds to using the newest batch of cream I got a few weeks ago. Did...
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    FDA withdraws approval of Anavar - filthy behaviour from manufacturer

    Empower sells oxandrolone. I have no idea how they get it or make it. Does anyone have an opinion on what this would do to their supply? I have a few bottles on the shelf. Have not used it out of caution, but would be nice to know I could still get it in the future if it became a treatment...
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    Testosterone mixed with MCT oil

    This is a doctor's office - not a pharmacy. Like an idiot, I asked my local TRT doc to send an Rx here and they got back to me and pointed out that it's someone else's practice! Do you happen to know what pharmacy they use?
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    All About Oxandrolone

    Hey, man, one thing to keep in mind is that this community is full of dudes who either have taken or are currently taking anti-depressants. We can debate their efficacy all day long, but the point is lots of guys feel they can't overcome a suboptimal mood that doesn't seem to rationally fit...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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