Search results

Defy Medical TRT clinic doctor
  1. C

    New to TRT. Received first labs. Concerned and need help.

    If you recall, I dismantled every one of your purported references. Not one refuted my claims. You basically relied on one study in which no subjects experienced physiological levels of testosterone throughout each injection cycle. Meanwhile, you continue to defend the indefensible: that a...
  2. C

    Hey everybody.

    It's important to have a good idea of free testosterone. Many of the existing tests are inaccurate and even use different scales. Which lab and which test did you use to obtain that figure of 63? What is the normal range? Going by total testosterone alone, TRT would be inadvisable. Also, if...
  3. C

    New to TRT. Received first labs. Concerned and need help.

    Low SHBG is associated with metabolic syndrome, but it doesn't seem to be an issue in your case. Anecdotally, it appears that men with low SHBG are more likely to have difficulties with TRT. There's also some speculation that low SHBG might impair androgen signaling by reducing the intracellular...
  4. C

    Experiences and Questions: Personal Experiments with Oral Native Testosterone Base & Enclomiphene (TRT+), Testosterone Propionate, HCG and more

    Use this site for Vermeulen free T. With TT of 45.2 nMol/L, SHBG of 37.8 nMol/L and albumin at 4.38 g/dL you get cFTV of 1.08 nMol/L, which is over 31 ng/dL. The top of the normal range for this is in the low 20s. In line with what @FunkOdyssey said, your peak level could easily be two or three...
  5. C

    New to TRT. Received first labs. Concerned and need help.

    While percent free testosterone is not a very useful number in general, that figure of 2.3% is suggesting that your pre-TRT free testosterone was around 11 ng/dL. Is this correct? If that was obtained by equilibrium dialysis then it's not a particularly low number. Your current high free...
  6. C

    TRT Dose question

    It's looking ok so far. The most recent measurement was 29 pg/mL taken about six weeks after dropping to these trivial doses of exogenous testosterone. Still a decent drop from the 40-60 it had been running previously. If anything I might be concerned about the E2/T ratio being high. The...
  7. C

    TRT Dose question

    I developed an aqueous testosterone solution, which I ended up diluting to 10 mg/mL. With my 0.3 cc insulin syringes I have 0.005 mL resolution. The threshold occurred between the dose rate of 0.15 mg testosterone taken three times daily and 0.05 mg testosterone, also three times daily. So this...
  8. C

    TRT Dose question

    I think interference with libido and sexual function by exogenous androgens is much more common than people think, even if not as dramatic as in your case. This was driven home to me by recent experiments in which a difference of 0.3 mg in the daily dose of testosterone made a very large...
  9. C

    Hey, 27 with mumps orchitis

    Assuming normal albumin, Vermeulen calculated free testosterone is around 7 ng/dL, which is on the low side. The normal LH points towards secondary hypogonadism, as does the response to hCG. This would suggest brain mediation—hypothalamic or pituitary—rather than testicular insufficiency...
  10. C

    Hey, 27 with mumps orchitis

    Do you have an AM total testosterone measurement to go with that SHBG? If you provide these two numbers then we can estimate free testosterone to get a better idea of your status. I assume that normal LH value was measured prior to TRT? Under conventional TRT it's expected to drop to low levels...
  11. C

    Hey, 27 with mumps orchitis

    You guys who potentially have primary hypogonadism may be interested in a slightly different approach to treatment. Here's one of various posts I've made on the subject: Having residual sexual issues on TRT sometimes means the dose of testosterone is too high, which isn't necessarily related...
  12. C

    TRT+ other medications

    For young men the effect becomes noticeable in the midrange of testosterone. Here are the data and plotted best-fit equations.
  13. C

    TRT+ other medications

    That's a decent summary in line with speculation over the years. What I'd like to see is an elaboration and quantification of this hypothesis that pulsatile T leads to more efficient E2 clearance and/or less efficient E2 production. The implication is that there's some added...
  14. C

    TRT+ other medications

    Ok, have some TRT 101: Injecting 25 mg of testosterone cypionate is not equivalent to injecting 70% * 25 mg TC = 17.5 mg testosterone, say in the form of suspension or oil-based solution. The latter would be mostly absorbed within the day and would represent a decidedly supraphysiological amount...
  15. C

    TRT+ other medications

    This is true, and the crux of the issue is whether integrated exposure causes the same or similar effects, at least in a susceptible subpopulation. The AI conclusion is that there is such risk. I guess you could argue that careful monitoring might warn you if you are a susceptible individual. In...
  16. C

    TRT+ other medications

    Hard to have a discussion if you won't admit to knowledge of even rudimentary aspects of TRT. Cite studies showing benefits, aside from improved musculature, that extend into above-physiological dosing and levels in a dose-dependent fashion. The only one I found showing benefits is this one. A...
  17. C

    TRT+ other medications

    I suggest you learn about pharmacokinetics. Now include the details that are in the subsequent posts. For example, that "too low" is based on the assumption of levels for healthy young men, as opposed to relative to an age-adjusted healthy reference range. There's also the fact that relatively...
  18. C

    TRT+ other medications

    You have no supporting evidence for that. Most men do well on one of the three doses of Zyosted, and only a small minority is even on the 100 mg dose. No, what irks me is your banal stream of misinformation, which ends up harming men by encouraging them to start with excessive doses or to...
  19. C

    TRT+ other medications

    Because virtually nobody is producing 12 mg of testosterone per day naturally. This mischaracterizes what I said. It may not be optimal for a slight majority, but in divided doses it would resolve some of the worst symptoms of hypogonadism. The reason for the low-and-slow approach is that many...
  20. C

    TRT+ other medications

    Wrong. Virtually nobody is naturally producing 12.5 mg T per day, so 125 mg TC/week is decidedly non-physiological for anybody. People like you can tolerate it, but that doesn't change my position that it's foolish to start "TRT" with such doses, and it's unlikely that such doses are optimal for...
  21. C

    TRT+ other medications

    Yet this phrase seems to come up when people want to skip directly to high doses without bothering to explore the physiological range first, which ironically is treating by numbers anyway. Yes, there are plenty of testimonials about the harm done in trying to make bigger doses work, as with...
  22. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    In theory, though it could be overstated. It would imply that a 1 mg dose would raise TT by around 2,000 ng/dL. I might use this dose for testing next time—in order to improve the signal-to-noise ratio. I'm not even going to attempt HPTA suppression, but if TT levels really hit well over 1,000...
  23. C

    TRT+ other medications

    This is highly misleading due to using trough values on weekly injections. That 125 mg dose is supraphysiological except near the end of each injection cycle.
  24. C

    TRT+ other medications

    Unfortunately your priorities are likely at cross-purposes. Some nontrivial fraction of men must choose between overall health—and sexual health in particular—and high-level physical performance. You can read about the experiences of others in this post. I would argue that your doses are above...
  25. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    Here's an interim update on this research. It had become clear that if I wanted to continue using small-gauge needles, e.g. 31 gauge, then I needed to create an aqueous solution; the particle sizes in even partial suspensions were too large to get a predictable dose. A new formulation that...
  26. C

    How can I regain my libido without side effects?

    There is a possible middle ground, which is topical finasteride, along with topical and/or oral minoxidil. I had unpleasant side effects from oral finasteride, and it took some time to make the connection and then recover. But as hair loss resumed I eventually gambled on going the topical route...
  27. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    As the point-by-point rebuttal has gotten repetitive, I'll skip to this, which I agree is the crux of the matter. In the end you've provided no evidence that there are advantages to starting TRT with this higher, non-physiological dose. In contrast, I have shown that lower starting doses can be...
  28. C

    TRT Dose question

    Trough levels on testosterone cypionate do tend to rise with a higher injection frequency—and variation decreases. A propionate blend given daily is a different animal. You would adjust the dose to give you an appropriate peak level, which you get within a few hours of the injection. The...
  29. C

    TRT Dose question

    If you're sufficiently motivated then a logical progression in the experimentation is daily injections of a cypionate/propionate blend. Then you remove the variation across different days and you can focus on how each day should be. With a blend you can control how much daily variation you want...
  30. C

    Experiences and Questions: Personal Experiments with Oral Native Testosterone Base & Enclomiphene (TRT+), Testosterone Propionate, HCG and more

    I post this occasionally to remind people to be careful with making inferences from LH measurements. Overall there's going to be a correlation with testosterone. But with any single measurement you don't know where you are with respect to the pulses. Endogenous testosterone is going to be like a...
  31. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    They are, but that should read "high starting dose". You added a "majority of men" qualifier. I'm not claiming to have quantified the rate at which men have problems at this dose. My point is that a midrange dose, say 50-80 mg TC/week, is less likely to cause side effects. While the general...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

Beyond Testosterone Podcast

Share this page

Sponsors

bodybuilder test discounted labs
buy enclomiphene
Discounted Labs
Testosterone Doctor Near Me
Register on ExcelMale.com
Trimix HCG Offer Excelmale
BUY HCG CIALIS
Beyond Testosterone Book by Nelson Vergel
Back
Top