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Defy Medical TRT clinic doctor
  1. C

    Inject hCG IM for better results?

    It may be far-fetched, but less so than some mysterious and unelucidated mechanism of testosterone destruction.
  2. C

    Inject hCG IM for better results?

    If with both SC and IM you ensured you had no injection site leakage and you measured free testosterone at enough time points in an injection cycle to accurately estimate AUC then you'd have some grounds to claim reduced bioavailability. What I've been saying is that measuring testosterone at...
  3. C

    Inject hCG IM for better results?

    Fair enough, since there's little, if any, hard data. Anecdotal reports appear to favor it. Grok says this: Injection site leakage, where a small amount of the oil-based medication (such as testosterone enanthate or cypionate) seeps out from the puncture wound after needle withdrawal, appears...
  4. C

    Inject hCG IM for better results?

    Occam's razor. There's injection site leakage, a known phenomenon that's almost certainly going to be more prevalent with SC injections. Then there's some mysterious, never directly observed, testosterone-destroying interaction that disappears under controlled conditions—and worse, is assumed to...
  5. C

    Inject hCG IM for better results?

    Somehow you forgot about the Xyosted study. Meanwhile there are no controlled studies pointing to dissimilar bioavailability for SC and IM. I presume if I were trying to support an argument with anecdotes that did not even measure the parameter in question then you would jump on that. But now...
  6. C

    Inject hCG IM for better results?

    As long as we're fantasizing that someone's going to fund such a study then of course it should include enough samples to generate accurate AUCs. But first, if you're rejecting the explanation involving injection site leakage then you should come up with a remotely plausible alternative...
  7. C

    Inject hCG IM for better results?

    Have to re-emphasize: "Clinical data consistently shows that SC administration of testosterone esters achieves comparable bioavailability to IM." Under controlled conditions the bioavailability is the same. What you're left with are basically three things: • Localized side effects. Ok, some...
  8. C

    Inject hCG IM for better results?

    Query to Grok: Someone asserts that testosterone esters have less bioavailability when delivered subcutaneously (SC) versus intra-muscularly (IM). I disagree, pointing to Xyosted clinical trials that show similar areas-under-the-curves. He then points to a study showing that hCG does have less...
  9. C

    TRT in Canada if borderline Testosterone and Prolactin?

    If you stop there one might think that elevated prolactin equals more dopamine activity. Nope. Modestly high levels of prolactin can reduce dopamine activity in men. Prolactin and dopamine have an inverse relationship in the brain, primarily regulated through the hypothalamic-pituitary axis...
  10. C

    7.5mgs daily labs

    Let's keep this in perspective: The lab measurement error is probably around the same size as or greater than the daily variation you see in levels. It's not something to even think about unless you shift to less frequent injections.
  11. C

    7.5mgs daily labs

    Your lack of understanding suggests either a problem with reading comprehension or else deliberate trolling. I've never said anything like that and yet here you are with a third admonishment in a two week period. The point is that with the long half-life of cypionate—actually more like five...
  12. C

    7.5mgs daily labs

    This is unnecessary. Men on daily cypionate will usually not see much variation.
  13. C

    TRT in Canada if borderline Testosterone and Prolactin?

    Prolactin works against dopamine, so it can contribute to the symptoms you describe. According to Dr. Saya, and also in my experience, in some men even prolactin over 10 ng/mL can cause issues. Perhaps it depends on the level that's appropriate for the individual's physiology. There's a simple...
  14. C

    Subcutaneous vs. Intramuscular Testosterone: Do Delivery Methods Affect Blood Health and Hematocrit Risk?

    Interesting that we used almost identical numbers to test this. I had SHBG of 40 and 27 nMol/L, FT of 13.6 and 13.1 respectively, the latter well within margins of error. Of course I also searched for the full text, but so far even the abstract only shows up on this page. It would be...
  15. C

    Starting Fertility Journey After Long-Term TRT – Seeking Insights

    That doctor is way too pessimistic. The studies suggest that a significant majority of men can regain fertility. It can take as long as one or two years, however. If you're wanting to hang onto the cypionate as long as possible then you might be interested in this speculative treatment...
  16. C

    Subcutaneous vs. Intramuscular Testosterone: Do Delivery Methods Affect Blood Health and Hematocrit Risk?

    This study should not be used to suggest that subcutaneous administration is less effective than intramuscular. First, free testosterone would be the more definitive measurement, and that was not used. Second, there's no mention of dosing. Then there's the hint of bias in the total testosterone...
  17. C

    7.5mgs daily labs

    To further elaborate on the low-and-slow philosophy: The key thing is to establish a solid reference point at reasonable levels, which is where you are now. Later on, if you think improvements are possible then you will have a point of comparison as you gradually raise the dose. It's common to...
  18. C

    7.5mgs daily labs

    I agree with @Seagal: Those are stellar numbers for just starting out, right in the midrange for healthy young men. Do give it some more time. If you haven't already, skim through this article to get a sense of the time frames for various improvements. Remember that TRT is not a cure-all, and...
  19. C

    New to TRT. Received first labs. Concerned and need help.

    I will continue to advise newcomers coming to this site with problems that a low-and-slow approach is preferred, backed up by scientific and anecdotal evidence. If you're going to keep butting in with contrary and harmful advice that is unsupported by any serious evidence then you can expect...
  20. C

    New to TRT. Received first labs. Concerned and need help.

    You can repeat this misinformation forever, but the study does not compare physiological to non-physiological doses, and therefore does not support your claim. The fact that a particular dose is tolerated in a short-term dose-response study does not indicate that it is suitable for long-term...
  21. C

    New to TRT. Received first labs. Concerned and need help.

    Which works in this fantasy world of yours where you can only choose between 125 mg/week and 50 mg/week in one dose. As I implied, there's plenty of evidence that physiological doses are safe and effective. It's up to you to prove that non-physiological doses are better, especially because you...
  22. C

    Less estradiol with faster-acting testosterone?

    I wouldn't expect enanthate to be much different from cypionate on similar dosing schedules. But it's perhaps harder to evaluate propionate if you're not measuring area-under-the-curve. Are you saying your E2/T ratio was the same? The limited propionate data I have also doesn't really support...
  23. C

    Less estradiol with faster-acting testosterone?

    Just putting this out for discussion and comments. There have long been anecdotal suggestions that faster-acting testosterone leads to lower overall levels of estradiol. In particular, it's often claimed in regard to using testosterone propionate versus longer esters such as cypionate. It could...
  24. C

    New to TRT. Received first labs. Concerned and need help.

    Ask yourself why we even have reference ranges. They are used to diagnose and treat disease/dysfunction. The dysfunction is clearly associated with levels above or below the range. I hope you aren't claiming otherwise. For all the supporting studies you claim to have, all you can do is return...
  25. C

    Testosterone Cypionate vs Testosterone Undecanoate

    Really good advice here. Going from TC once every two weeks to TU is like going to the opposite end of the spectrum. You currently have this enormous variation in serum testosterone over each two-week cycle, with troughs being something like 10-20% of peaks, and peaks likely over 1,000 ng/dL...
  26. C

    New to TRT. Received first labs. Concerned and need help.

    It's refreshing to see some marginally clever pushback interspersed with the usual inanities. Unfortunately it falls short, because fitness is good.
  27. C

    New to TRT. Received first labs. Concerned and need help.

    The burden of proof clearly is on you with the extraordinary claim that non-physiological levels are better for overall health and should be the default starting point for TRT. As I went through your list of references it became clear that you had not read them and were relying on a faulty AI...
  28. C

    New to TRT. Received first labs. Concerned and need help.

    In real life men thrive on physiological levels of testosterone. Think the current president @ 441 ng/dL. On TRT some men get away with higher levels, while others suffer side effects and come here, as you well know. What would I do without your incredible wisdom? Maybe I should eat right and...
  29. C

    New to TRT. Received first labs. Concerned and need help.

    I'm not sure what you're referring to. I don't recall even expressing an opinion on the prevalence of this side effect. I did tell you that TRT had the opposite effect on me, with higher doses being somewhat sedating and demotivating. The side effects of excessive testosterone that I've...
  30. C

    Thyroid Labs for Dixiewrecked

    I'm not saying this applies to you, but I went down the thyroid rabbit hole with Defy and now think it's a case of treating the side effects without looking into the underlying cause. I had top-of-range reverse T3, which they treated with a T3 prescription. It brought down rT3, but didn't seem...
  31. C

    New to TRT. Received first labs. Concerned and need help.

    How quickly they forget. After this point-by-point examination of your references you didn't even attempt a response. https://www.excelmale.com/threads/trt-other-medications.32780/post-300919 All this study shows is that being hypogonadal is somewhat worse than being mildly hypergonadal...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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