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  1. FunkOdyssey

    What is Post SSRI's (Antidepressants) Sexual Dysfunction

    I'm sure I would if I bothered to share that. I find doctors totally useless at solving anything there isn't a well known treatment algorithm for, so I see no value in discussing it. You would have better luck with ChatGPT at this point if you want creative medical problem solving.
  2. FunkOdyssey

    Test levels DROPPED after RAISING dose

    This is confirmation of what I'm saying here, that OSA is really the larger factor, more so than the testosterone. So, if you want to run more testosterone, attack the OSA harder. And if you want more consistent levels, it is my opinion you'll get that with IM.
  3. FunkOdyssey

    Test levels DROPPED after RAISING dose

    I would think E3.5D with IM is going to have peaks large enough to make a significant negative difference. I would not make that move while struggling with hematocrit. How are you tracking the effectiveness of your OSA treatment? I bet there is room for improvement. This is likely the real...
  4. FunkOdyssey

    Test levels DROPPED after RAISING dose

    I personally find EOD IM with long esters to be a great compromise of stability and side effect management without having to poke yourself every day. I would be surprised if there were any substantial hematocrit difference between daily SC and EOD IM with cypionate at equivalent doses. Your...
  5. FunkOdyssey

    Test levels DROPPED after RAISING dose

    May I suggest injecting into the muscle instead? You may be like many of us, where your subcutaneous tissue is like a black hole that mysteriously makes testosterone disappear.
  6. FunkOdyssey

    Any advice?

    Probably needs to drop more to make a significant difference in both numbers and symptoms. I would drop 20 mg to 130 mg.
  7. FunkOdyssey

    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    I wouldn't run this experiment personally because I know the seed oil diet causes obvious problems for me. Oxidized LDL might be more sensitive as a marker for this. My most recent hs-CRP is 0.27 mg/L and oxidized LDL is 30 ng/mL on carnivore diet.
  8. FunkOdyssey

    Testosterone dropped after a few months on the same dose

    I would test one more time to make sure there wasn't a lab error or something. If your testosterone comes back low again, take more. Your first set of labs was quite high for your dose anyway, it would be the second result that makes more sense IMO.
  9. FunkOdyssey

    Testosterone dropped after a few months on the same dose

    Can you tell us more about your injection method / site / depth? Same vial of test used in both cases?
  10. FunkOdyssey

    What is Post SSRI's (Antidepressants) Sexual Dysfunction

    My overall function still isn't great, but I have had flashes or windows of major improvement, particularly lately while experimenting with adding hCG to my TRT. I'm working on dialing in the combination.
  11. FunkOdyssey

    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    The seed oils your restaurant meals are cooked in are still doing damage even if things look good on the surface. Try a month of home cooked meals, then a month eating out, testing hs-CRP, oxidized LDL, and myeloperoxidase at the end of each month to assess the CVD risks of each lifestyle pattern.
  12. FunkOdyssey

    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    Yes it did.
  13. FunkOdyssey

    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    Some of them disappear, yes. Tolerance builds to the stimulant effects, and associated side effects, including anxiety, fast heart rate, insomnia, etc. Dose-limiting side effects for me have been cognitive impairment with high doses of prop (20+ mg), particularly in the middle of the workday...
  14. FunkOdyssey

    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    I was like this when I first started: a dose of 10 mg prop would nearly cause me a panic attack. Something has changed over time, and it does not affect me like that anymore, even with much larger doses. I can take 30 mg now and only feel a mild uplift of energy and mood. I suspect you would...
  15. FunkOdyssey

    Anyone Used Hikma Testosterone Enanthate?

    Hikma testosterone enanthate is great stuff. When I first started TRT, it was actually the only formulation that I could tolerate well. Over time, I have somehow become more normal and am able to use a variety of formulations. It still holds a fond place in my heart, and we continue to use it...
  16. FunkOdyssey

    Shallow Testosterone IM versus SubQ Injections - Lab Results

    There is not academically rigorous evidence, but there is overwhelming evidence. Literally overwhelming, in that if I summoned to this thread everyone on just this forum alone who has reported this phenomenon, you will have too many responses to manage. Let alone if I were to take the time to...
  17. FunkOdyssey

    Shallow Testosterone IM versus SubQ Injections - Lab Results

    I think this is the key to the lower testosterone levels often seen with SC injections. The testosterone is being exposed to a ton of immune cells in the lymphatic system before it is able to reach circulation. It may be eaten by macrophages (either receptor mediated uptake or phagocytosis)...
  18. FunkOdyssey

    Shallow Testosterone IM versus SubQ Injections - Lab Results

    As many of us have learned the hard way, the reality of subcutaneous injections is often quite different than the rosy picture painted by the studies.
  19. FunkOdyssey

    Dhea and pregnelone

    Looks like another DHEA casualty.
  20. FunkOdyssey

    Is Fiber Really Essential?

    No, absolutely not:
  21. FunkOdyssey

    Maximus: Oral TRT+ (native T + enclomiphene + pregnenolone)

    Everyone is started on 600 mg, with the option to increase to 800 mg. If you wanted to start at 400 mg, that is something you could work out with your Maximus provider. The effective dosage can also be adjusted by varying the amount of co-ingested fat. For example, 600 mg taken with 20-30 g...
  22. FunkOdyssey

    High estradiol and SHBG 10wks into TRT (was high on enclomiphene too) - long winded post sorry.

    If injection frequency is equal, subcutaneous injections DO give you more stability than IM injections. EOD IM injections will be more stable than twice weekly subq though. There are some discrepancies between published studies and real life with regard to subq vs IM injection. In many men or...
  23. FunkOdyssey

    High estradiol and SHBG 10wks into TRT (was high on enclomiphene too) - long winded post sorry.

    Your free T is going to drop proportionately to your dose reduction. What type of free testosterone test did you have performed? A calculated free T based on 1500 ng/dL total and 67 nmol/L SHBG would be 25 ng/dL free T. That's probably a more reliable number, and if that was the trough of a...
  24. FunkOdyssey

    High estradiol and SHBG 10wks into TRT (was high on enclomiphene too) - long winded post sorry.

    By the way, I am a fellow GERD sufferer and have seen this worsen with TRT depending on the form and dosage. The effects of androgens vs estrogen here are distinct: estradiol relaxes the lower esophageal sphincter to promote more reflux events, while androgens somehow make the reflux more...
  25. FunkOdyssey

    High estradiol and SHBG 10wks into TRT (was high on enclomiphene too) - long winded post sorry.

    Actually, you might need your total T to be that high, or even higher, to have a decent free T with that high SHBG. You need to retest testosterone with a proper LC/MS method though so you can see where that actually sits. Your high E2 is also similarly artificially inflated by your high SHBG...
  26. FunkOdyssey

    Retatrutide noob questions (order already done)

    This doesn't seem entirely true. Without lifestyle changes, dose escalation is required over time to maintain the effects, until eventually tolerance builds to the highest tolerable dose and weight starts increasing again even as the drug is continued. This process seems to take a few years from...
  27. FunkOdyssey

    Instant Blood Pressure Spike on Starting TRT

    Those don't exist. This is what you want for minimum gauge, maximum length for reaching the muscle at fattier sites like ventroglutes: Easy Touch U-100 Insulin Syringe with Needle, 27G 1cc 5/8-Inch
  28. FunkOdyssey

    Help a guy to fine-tune his bimix dose

    Bi-Mix is much more forgiving than Tri-Mix with dosing too high, because the medications have a shorter duration of action than the alprostadil in Tri-Mix. I think you would be fine to increase to 8-10 units without any risk of a 4+ hr erection.
  29. FunkOdyssey

    Instant Blood Pressure Spike on Starting TRT

    I would suggest something like 20 mg every other day to start with. If you still find that intolerable, go even lower. There are diminishing returns moving from every other day to daily with cypionate, but you can also try that if you're willing. Run labs after 6+ weeks, note your progress with...
  30. FunkOdyssey

    Estradiol valerate experiment .

    I don't remember what my protocol was like at the time of this experiment - currently doing 37.5 mg test cyp EOD for 131 mg weekly. I'm done with prop after the massive peak levels drove down my HDL, among other issues.
  31. FunkOdyssey

    Instant Blood Pressure Spike on Starting TRT

    Dividing the same weekly dose into smaller, more frequent injections almost always reduces side effects compared to larger and less frequent injections. There are rare exceptions, but this is the rule.
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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