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    High SHBG, Low free T.

    Your free testosterone isn't extremely low, so it's borderline whether you should be characterized as hypogonadal. Nonetheless, there are at least some suggestions that very high SHBG like yours may interfere with androgenic activity. Therefore I wouldn't condemn you for wanting to experiment...
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    GHK-cu and DHT

    What dose size are you targeting? Going with 1 mg/mL is likely more concentrated than you want, especially if you're not using 0.3 cc syringes with half-unit markings. Suppose you're using 1 cc U-100 syringes and want a 2 mg dose. Then you'd be better off with the original dilutions you...
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    Lab results

    You heard wrong. The normal range for Vermeulen calculated free testosterone is about 7-22 ng/dL, with 13-17 being typical for healthy young men. I've never encountered anyone who is genuinely hypogonadal with cFTV greater than 10 ng/dL. You could be that rare exception, but it's more likely...
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    GHK-cu and DHT

    You can do either depending on what makes it convenient to take the intended dose. With 50 mg/mL you have 0.5 mg/unit in a U-100 insulin syringe. With 50 mg/ 2 mL = 25 mg/mL you have 0.25 mg/unit. I tend to initially mix 100 mg GHK-Cu with only 1 mL of bacteriostatic water, but my multiple 1...
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    Initiative Calls for Updated Standards in Testing for Suspected Low Testosterone

    “However, many commercial labs use an assay that purports to directly measure free testosterone, the so-called direct free testosterone,” Dr. Dunaif says. “This assay has been found to be totally inaccurate and should never be used.” @Dr Justin Saya MD, when is Defy Medical going to stop...
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    My blood test results on enclomiphene

    You have good numbers for being on a fairly low dose of enclomiphene. You're responding better than those in the clinical trials, where only the 25 mg cohort had really respectable levels on average.
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    High testosterone is like … finasteride? Say what!

    It is possible. Assuming the injections are comparable to Natesto, which is not a given, then that modest HPTA suppression combined with a little more from hCG might still allow for some LH production. It's probably a situation where different individuals could see different outcomes.
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    High testosterone is like … finasteride? Say what!

    When blending propionate with either enanthate or cypionate I found that getting half of the testosterone from each ester gives a diurnal variation in levels that is at the high end of normal, around +/-25% about the mean, or a 40% drop from peak to trough. We discussed a lot of the nuts and...
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    High testosterone is like … finasteride? Say what!

    No, they are more like Natesto. There's a rapid spike in levels followed by a relatively swift decline. As a standalone TRT method they would need to be used at least 2-3 times daily.
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    PP405 Possible Breakthrough Treatment for Hair Loss

    Still a ways off with the Phase 2A trial just getting started. If it continues to look good then it may show up on research chemical sites before FDA approval, depending on its legal status.
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    High testosterone is like … finasteride? Say what!

    Natesto has the evidence behind it. It's the only form of TRT proven to allow continued HPTA function, which in my mind makes it more physiological. Oral forms cause more complete suppression unless accompanied by a SERM. It's likely that appropriately dosed buccal troches would be similar in...
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    Dialed in on Testosterone Propionate, How to Switch to Cypionate

    It comes as 100 mg/mL, but I dilute it to 50 mg/mL for quarter-milligram dose resolution.
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    Dialed in on Testosterone Propionate, How to Switch to Cypionate

    Suspensions are water-based. In this case there are micronized testosterone particles suspended in the carrier; being hydrophobic they do not dissolve as they would in oil. The injections are spaced six hours apart. No blood work yet, but I am seriously considering doing a sequence of tests to...
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    Question about dosing.

    The slower the transition, the less the likelihood of side effects. If you limit the reduction to a few milligrams per week then you may not even notice it. But then it will take a few months to complete. With respect to anxiety, have you ever tested your serum progesterone? Frequently it is...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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