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  1. FunkOdyssey

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    I love that you did this experiment and wrote up all of the details for us. Very puzzling results though!
  2. FunkOdyssey

    Building a TRT protocol around hCG

    Cortex released a video on this concept of using hCG and DHEA as the foundation of a protocol and then tailoring testosterone dose around that: I have kept going back and forth with hCG myself. I've noticed, now that I have some Janoshik-verified potent hCG (eutrig), if I take 250 iu EOD...
  3. FunkOdyssey

    Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week

    Fasting insulin and lipid panel (HDL and triglycerides specifically). Many of us had sleep issues in the beginning, and water retention is pretty much a given. Most or all of the water retention disappears eventually as you adapt to the new levels. You will certainly be able to find a dose...
  4. FunkOdyssey

    Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week

    That's your fasting glucose, not fasting insulin. You want to see your fasting insulin to determine whether you have insulin resistance. Your lipid panel has some big clues also, between HDL, triglycerides, and their ratio. Insulin resistant men often have a rough time on TRT. They aromatize...
  5. FunkOdyssey

    Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week

    Do you recall what it was?
  6. FunkOdyssey

    Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week

    These free T numbers you are reporting are bogus - likely labcorp direct free T if I had to guess. Your real free T (vermeulen calculation) with 100 mg was 21.8 ng/dL assuming 4.3 albumin, which is a very reasonable level for men on TRT. You have a high SHBG, so this reasonable free T is...
  7. FunkOdyssey

    Advice on next steps - mid-low free T

    True, but importantly, there's not even a hint in these 20+ studies that looked at effects of TRT on cognition that the lack of GnRH is causing cognitive deficits either. Some trends in that direction would be very persuasive in terms of convincing me to take this GnRH issue seriously. There...
  8. FunkOdyssey

    Experiences and Questions: Personal Experiments with Oral Native Testosterone Base & Enclomiphene (TRT+), Testosterone Propionate, HCG and more

    This is quite plausible. Your absolute level of E2 is low, the ratio of T & DHT / E2 is very high, and you have enclomiphene antagonizing estrogen receptors on top of that. I would rather take less of something in this situation than add another compound to increase estradiol. Reducing the...
  9. FunkOdyssey

    Advice on next steps - mid-low free T

    I've actually been on test cyp for the last couple months and it's working fine for me. 35 mg EOD.
  10. FunkOdyssey

    Help with blood test results and erectile dysfunction

    Ran into this article today on CGM benefits in early type 2 diabetes (see attached).
  11. FunkOdyssey

    Help with blood test results and erectile dysfunction

    Great suggestions from Guided above. The Clot Thickens is a must read. Chromium can be effective, but can also cause major insomnia in some; watch for that. Time restricted eating, definitely. Avoid seed oils, definitely. Absolutely agree. He actually provided a fasting insulin level in his...
  12. FunkOdyssey

    Advice on next steps - mid-low free T

    In my opinion, it's more helpful to think about specific target levels, independent of reference ranges, which vary widely from lab to lab. You'll test total testosterone, and you'll need it (together with SHBG) to calculate free testosterone, but free testosterone is where the rubber meets the...
  13. FunkOdyssey

    Advice on next steps - mid-low free T

    The following review discusses the findings of over 20 studies that investigated the effects of TRT on cognition, in both healthy men, and men with Alzheimer's or other forms of cognitive decline. We might expect worsened cognition if the lack of GnRH is impactful, or an acceleration of...
  14. FunkOdyssey

    Advice on next steps - mid-low free T

    It sounds reasonable, and might be helpful in some cases.
  15. FunkOdyssey

    Advice on next steps - mid-low free T

    One more thought I had about GnRH: humans pre-puberty have little/no GnRH secretion, and with varying age of puberty, some will have spent more or less years of their life in this low GnRH state. If the absence of GnRH is harmful then, we might expect later puberty to correlate with increased...
  16. FunkOdyssey

    Advice on next steps - mid-low free T

    Testosterone with no ester attached.
  17. FunkOdyssey

    Advice on next steps - mid-low free T

    GnRH has neuroprotective and anti-aging effects in mice. However, studies of men on TRT with suppressed GnRH do not show higher rates of dementia, nor do they show higher rates of all cause mortality. If the lack of GnRH is having negative effects then, it's either too subtle to affect health...
  18. FunkOdyssey

    Advice on next steps - mid-low free T

    Compounded bioidentical / native testosterone in a lipid-based delivery vehicle, similar in that respect to Kyzatrex and the other oral TU products. The bioidentical testosterone is better tolerated than TU with fewer gastrointestinal side effects, and appears to be less suppressive of the HPT...
  19. FunkOdyssey

    Advice on next steps - mid-low free T

    In the kyzatrex trial I mentioned, they started at 7 ng/dL free T and increased by 7 ng/dL to 14 ng/dL with the 200 mg bid dose. I would be looking to create a dramatic difference from your 10 ng/dL baseline with this experiment to ensure the results are noticeable, and targeting something more...
  20. FunkOdyssey

    Advice on next steps - mid-low free T

    hCG will only complicate things - I would leave that out (at least initially). I work for Maximus so my bias is towards our oral testosterone, but with Kyzatrex, you will need much higher doses than 100 mg to move the needle. 200 mg bid only produced 14 ng/dL free T in their phase 3 trial. You'd...
  21. FunkOdyssey

    Advice on next steps - mid-low free T

    Just curious: how did you manage to have four kids by age 30, having been in med school and residency the entire time? I feel like there's a story there.
  22. FunkOdyssey

    Advice on next steps - mid-low free T

    I'll give you my less conservative perspective. Yes, I would experiment with increasing T levels, given your symptoms, which would produce a positive result on the ADAM questionnaire. Your levels, while not low, are not high enough to rule out the possibility that more T could improve the...
  23. FunkOdyssey

    Advice on next steps - mid-low free T

    We have data showing no statistically significant suppression with once daily oral testosterone at Maximus which will be published soon on the website. The shorter half-life of bioidentical oral testosterone vs. testosterone undecanoate is likely responsible. Please see attached excerpts.
  24. FunkOdyssey

    Testosterone dropped after a few months on the same dose

    I don't have a trough level for my current protocol, but I took a midpoint level of 1230 ng/dL total, 28 ng/dL free, 30 pg/mL e2. This was on 35 mg test cyp EOD, and I took labs afternoon of the day after injection.
  25. FunkOdyssey

    Testosterone dropped after a few months on the same dose

    I'd be going alot higher with these labs. There's being careful, there's being very careful, and then there's just straight up wasting time. Straight to 100 mg if it were me, at least.
  26. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    They suggest 25-50 mg a week, because above 50 mg it supposedly causes paradoxical estrogenic effects via conversion to 3b-androstanediol.
  27. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    No, that looks amazing. So expensive though, wtf.
  28. FunkOdyssey

    Any Testosterone Propionate Compounding Pharmacies left?

    Most people who are still using test prop have been forced to switch to UGL suppliers.
  29. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

  30. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    Which alternative source for topical DHT do you suggest? There aren't exactly a plethora of options. That's the only product I'm aware of that has reliably worked for everyone who used it (including myself and RL friends). 100% DMSO would explain the skin rape though.
  31. FunkOdyssey

    Help with blood test results and erectile dysfunction

    If continuous glucose monitors are available over-the-counter where you live, you should wear one for some time. If they aren't available OTC, see if your doctor will prescribe one for you. The minute to minute biofeedback on your glucose levels is invaluable for someone seeking to improve their...
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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