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  1. FunkOdyssey

    TRT+ other medications

    Your comment touches on a very interesting phenomenon with hCG that has puzzled me: hCG monotherapy is capable of producing high physiologic levels of testosterone. It is not uncommon for men to produce 600, 800, 1000 ng/dL or higher testosterone with hCG monotherapy. However, when hCG is...
  2. FunkOdyssey

    TRT+ other medications

    Another thought: natural, pulsatile LH can produce supraphysiologic aromatase activity / E2 production too, when LH is increased to supraphysiologic levels. We see this often with enclomiphene therapy, where the T/E2 ratio drops significantly compared to baseline, as E2 climbs faster than T.
  3. FunkOdyssey

    TRT+ other medications

    I do not see this as an issue with exogenous testosterone, and the fact that it is not I think falsifies the constant production -> impaired clearance hypothesis. In most cases, if you reach the same level of testosterone using injectable TRT for example as you had naturally, you would not have...
  4. FunkOdyssey

    TRT+ other medications

    Not a problem - if supplies run low, we simply establish a new slave class of women who are kept pregnant at all times to harvest hCG from. According to The Handmaid's Tale, this should work for many years before they rebel and assassinate us.
  5. FunkOdyssey

    TRT+ other medications

    It's xyosted with an X. He doesn't use xyosted, he just likes it because it is offered in doses that put men in a physiologic range. When the primary measure of success is reaching a normal level of testosterone, xyosted allows most men to declare victory at 75 mg. Have they left any benefits...
  6. FunkOdyssey

    TRT+ other medications

    A total T 5.2x the level of controls was associated with vascular dysfunction in that study. The human equivalent dose of the 10 mg/kg used in the mice would be 0.81 mg/kg, or 73 mg test prop daily in a 90 kg individual such as myself. Just want to note these things for context...
  7. FunkOdyssey

    TRT+ other medications

    I don't think clinical trials for Xyosted can be used to argue that 75 mg is optimal for most men, because dosages were adjusted based on targeting a 350–650 ng/dL trough, so the only men who increased to 100 mg landed below 350 ng/dL. They were more interested in achieving physiologic levels...
  8. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    Not monotherapy, it will be suppressive. At least a base of hCG should be used with it, if not full TRT + hCG + DHT.
  9. FunkOdyssey

    Anabolic steroid use can increase heart disease risk

    https://www.newsweek.com/hulk-hogan-dead-71-wrestler-died-after-cardiac-arrest-call-updates-2103588
  10. FunkOdyssey

    Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week

    No problem. I forgot to comment on the hbA1c and insulin which were actually pretty good. I would not be thinking about metformin with those numbers. Getting leaner is probably all you need to worry about right now.
  11. FunkOdyssey

    Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week

    Yes, you want to ignore the free T levels you are seeing on the labwork and calculate it yourself using your total T, SHBG, and optionally albumin if you have it: Free & Bioavailable Testosterone calculator No, the iron at 104 is not high, its the ferritin that's high. TSAT is calculated from...
  12. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    My friend who was using Alphagels topical DHT, back when it still contained actual DHT, found that the optimal dose was much lower than most people were experimenting with: 0.25 ml, either daily or every other day. On top his regular TRT, this small amount had major benefits for his sexual...
  13. FunkOdyssey

    Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week

    Calculated free T is 15.1 ng/dL now, which is decent but not where I would want to be. E2 is way down, which is great. Did you switch to IM before these labs? Had you stopped DHEA before these labs? E2 dropped more than the TRT dose adjustment alone would explain. Ferritin is higher than...
  14. FunkOdyssey

    TRT and stacking for weight loss

    You aren't going to lose weight and gain significant muscle at the same time, so let's assume you are prioritizing weight loss first. GLP-1, preferably retatrutide, done. Add keto / carnivore diet for extra credit and the ability to maintain the weight loss without a GLP-1 drug.
  15. FunkOdyssey

    TRT+ other medications

    I concur with Phil on what you should do. You should drop your TRT dose back down, restart the hCG, and tune the dosage of both so that the sum total E2 produced does not require an AI to prevent side effects. This is going to give you a better quality of life, good sexual function, and...
  16. FunkOdyssey

    Building a TRT protocol around hCG

    I still think it is going benefit most people, and hope you won't be discouraged from your own experimentation. With my history of accutane and SSRI use, I am likely broken in some unique ways. And I will probably still try a lower dose again, when I return from vacation. Sleep has not been...
  17. FunkOdyssey

    Building a TRT protocol around hCG

    This experiment has not gone very well for me so far. I've been on hCG for over a month now, with some varying doses at first but settling at 150 iu daily, combined with 15 mg test cyp daily. I did feel some improved sensitivity in the beginning, which went away. I also noticed signs of life...
  18. FunkOdyssey

    Experiences and Questions: Personal Experiments with Oral Native Testosterone Base & Enclomiphene (TRT+), Testosterone Propionate, HCG and more

    My labs while running ~19 mg test prop daily, MCT oil, shallow IM in ventroglutes: Peak (labs taken 5.5 - 6 hrs after injection) 49 ng/dL Free T 56 pg/mL E2 Total T: 1818 ng/dL Trough (next morning 8 am) 19 ng/dL Free T 22 pg/mL E2 Total T: 840 ng/dL Yes, you can do that. You just draw up...
  19. FunkOdyssey

    Erythritol adversely affects brain microvascular endothelial cell function

    Ironic that this sugar alcohol which health conscious people used to avoid the harms of sugar turned out to be much more harmful than sugar.
  20. FunkOdyssey

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    Look WIlly, this is my clinic, so you're going to take your supraphysiologic dose and like it! Now go out and enjoy life in your new suspiciously athletic body.
  21. FunkOdyssey

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    Agreed. Maybe some minor sarcasm here and there, nothing serious. Hats off to you sirs, for an entertaining discussion between gentlemen.
  22. FunkOdyssey

    The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015)

    No, I'm caffeine-free. I would guess it was the amphetamine metabolites causing most of the noticeable effects, as I took one sublingual dose some months ago and didn't really feel anything noticeable at all.
  23. FunkOdyssey

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    Vince makes a good example patient. If lean and mean, low-aromatizing Vince rolls into your TRT clinic on his Harley, and you give him 50-75 mg a week, he's going to have single digit E2, hate his life, and hate you. Needless suffering indeed!
  24. FunkOdyssey

    Follow up on lab panel

    Everything else being equal, more frequent injections usually produces lower hematocrit levels than less frequent injections. With E2, you're probably going to see that go up, only because your trough level is now higher. Don't treat the E2 number though. If you don't have estrogenic sides...
  25. FunkOdyssey

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    If I may insert a thought here, I don't think starting everyone either higher (100-120+ mg) or lower (50-75 mg) makes sense. I think with some baseline testing and information gathering, you can predict with pretty good accuracy (not perfect accuracy, but reasonable accuracy) who is going to...
  26. FunkOdyssey

    High E2 (~50 pg/mL) on HCG/Enclomiphene/Anastrozole: Mood, Acne, Fog

    Yes, this was all very normal. E2 was probably on the high side because of the extra fat you hadn't lost yet. You seem to correctly understand that the cause of your symptoms was probably stress, and not testosterone deficiency. There are different schools of thought around TRT and...
  27. FunkOdyssey

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    Yes he has news. @Jerajera
  28. FunkOdyssey

    High E2 (~50 pg/mL) on HCG/Enclomiphene/Anastrozole: Mood, Acne, Fog

    What were your starting levels and symptoms that led you to a hormone optimization clinic? You haven't mentioned free T yet, and that needs to be talked about (your original baseline and what it is currently), as that is far more important than your total testosterone. It can be calculated from...
  29. FunkOdyssey

    High E2 (~50 pg/mL) on HCG/Enclomiphene/Anastrozole: Mood, Acne, Fog

    You're taking too much of everything. You don't need to be at 1376 ng/dL to get someone pregnant. I bet you could get the job done fertility-wise with a lower dose of enclomiphene like 6.25 mg, no hCG, no AI, and feel a hell of a lot better than you do now.
  30. FunkOdyssey

    Still trying to figure this out - 120mg to 100mg to now 80mg - what a rough week

    Yes, DHEA can absolutely contribute to elevated estrogens, not just E2, but E1 as well (estrone). Yes, it can and does often make people feel like crap. Experimenting with cutting it out is a great idea.
  31. FunkOdyssey

    TRT Dose question

    My vote would be 25 mg twice weekly.
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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