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  1. Nelson Vergel

    The Evolution of Testosterone Products in the U.S. (1935-2025)

    https://www.excelmale.com/threads/testosterone-products-oral-transdermal-injectable-and-more.1487/
  2. Nelson Vergel

    The Evolution of Testosterone Products in the U.S. (1935-2025)

    https://www.excelmale.com/threads/fda-approved-testosterone-products-in-the-united-states-2024.30465/
  3. Nelson Vergel

    The Evolution of Testosterone Products in the U.S. (1935-2025)

    Thanks to Dr Sun for this diagram. Timeline details (left → right) YearProduct (image above/below the line)Form & delivery 1935-1937No product image—text block below the line: “Testosterone first synthesized” with a bullet list of early preparations (oral 17α-methyltestosterone, injectable...
  4. Nelson Vergel

    Zimislecel: Stem Cell–Derived, Fully Differentiated Islets Cured Type 1 Diabetes?

    Wow. I hope the deaths had nothing to do with the treatment.
  5. Nelson Vergel

    Severe Muscle Pain from Crestor?

    Get your CPK level tested. If high, your doctor can justify a prescription for Repatha due to "statin intolerance". $24 : CPK Blood Test (Creatine Phosphokinase) | Discounted Labs Repatha (Evolocumab) Prescription in Statin-Intolerant Patients with High CPK Background Statin intolerance...
  6. Nelson Vergel

    Sperm result after 3 months of HCG. What would you do?

    HMG is very expensive and hard to get. I would increase hCG to 3000 IU every other day plus TRT, or bring in clomiphene or enclomiphene at 25 mg/day plus hcg 1500 UI every other day. I may even get off TRT for a while. Also keep in mind these supplements...
  7. Nelson Vergel

    High levels of antihistamine drugs can reduce fitness gains, study finds

    Thank you.
  8. Nelson Vergel

    Clomid for Testicular Shrinkage ?

    Forum Perspectives on Clomiphene (Clomid) for Testicular Recovery Reddit Community Insights · Testicular Size and Function: Many Reddit users report noticeable increases in testicular size after starting clomiphene, especially if their testicular atrophy was related to low LH/FSH or prior...
  9. Nelson Vergel

    What No One Tells You about Testosterone Replacement Therapy

  10. Nelson Vergel

    Damage to my penis... please help

    Unfortunately, I would just take ibuprofen daily and try not to masturbate or have sex. Your penis needs rest. Some urologists, like Dr. Lipshults, recommend these to minimize penile fibrosis. There are no good studies to prove they are effective. Over-the-Counter (OTC) Supplements and...
  11. Nelson Vergel

    FSH stimulates aromatization

    Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis. https://pubmed.ncbi.nlm.nih.gov/26908066/
  12. Nelson Vergel

    Therapeutic Phlebotomy...local Quest and Labcorp refuse to do it

    I said blood banks, NOT Quest or LabCorp. Here are places around the US: https://www.discountedlabs.com/blog/where-to-get-therapeutic-phlebotomies-to-lower-high-hematocrit-in-the-us
  13. Nelson Vergel

    Treatment of Chronic Fatigue Syndrome and Fibromyalgia with D-Ribose

    Very hopeful approach to improve chronic pain and fatigue https://www.healthrising.org/blog/2025/06/22/neuroinflammation-tfus-jarred_younger/
  14. Nelson Vergel

    Elevated Hematocrit from Testosterone Therapy vs High-Altitude Adaptation: A Comparative Analysis

    https://www.excelmale.com/threads/testosterone-therapy-and-erythrocytosis-the-most-common-dose-limiting-effect-of-testosterone-therapy.30257/
  15. Nelson Vergel

    The Psychedelic Revolution Is Coming

    Who Will Own the ‘God Molecule’? Psychedelics devotees are racing biotech entrepreneurs to turn 5-MeO-DMT into a pharmaceutical. https://nymag.com/intelligencer/article/god-particle-5-meo-dmt-drug-pharmaceutical-market.html
  16. Nelson Vergel

    Elevated Hematocrit from Testosterone Therapy vs High-Altitude Adaptation: A Comparative Analysis

    I think increased BP after starting TRT and seeing an increased hematocrit is THE indicator that your cardiovascular system is not as "flexible" as it should be to handle either increased blood volume (edema) and/or increased viscosity due to higher red blood cell concentration. Younger guys...
  17. Nelson Vergel

    TRTManager for iOS

    Great idea! @Jason Sypolt created a site 9 years ago but we failed to maintain it. https://www.excelmale.com/threads/new-testosterone-replacement-analyzer-app.29267/ https://www.discountedlabs.com/blog/new-trt-analyzer-app-just-launched
  18. Nelson Vergel

    Is this real?

    From Perplexity: What Russia Has Actually Announced · Alexander Gintsburg, head of Moscow’s Gamaleya National Research Center, says the institute has built an mRNA “oncovaccine” that will be customized for each patient’s tumor with the help of artificial-intelligence algorithms[1]. ·...
  19. Nelson Vergel

    Smoking Cessation's Effects on Male Hormonal Levels

    This scientific paper investigates the effects of smoking cessation on hormonal levels in men, specifically focusing on steroid hormones like testosterone, DHEA, DHEAS, cortisol, and sex hormone-binding globulin (SHBG). The researchers aimed to determine if these hormonal levels could predict...
  20. Nelson Vergel

    Falling off a cliff in New Zealand.......Help!

    https://www.excelmale.com/threads/starting-on-trt-compound-cream-and-joining-the-forum.26590/page-2
  21. Nelson Vergel

    Falling off a cliff in New Zealand.......Help!

    https://www.excelmale.com/threads/greetings-from-new-zealand-compounded-testosterone-cream-q-a.21815/
  22. Nelson Vergel

    Falling off a cliff in New Zealand.......Help!

    https://www.excelmale.com/threads/testosterone-doctors-in-new-zealand.15983/
  23. Nelson Vergel

    Anastrozole - Enduring Side Effects 5 Years Later

    The Role of Estradiol (Estrogen) in Men's Health and Testosterone Replacement Therapy (TRT) This briefing document synthesizes information from various discussions on the Excel Male TRT Forum regarding the critical role of estradiol (estrogen) in men's health, particularly in the context of...
  24. Nelson Vergel

    Anastrozole - Enduring Side Effects 5 Years Later

    Anastrozole for men” increasingly appears in medical literature, endocrine clinics, and online forums as clinicians and patients look for ways to balance testosterone‐to‐estrogen ratios, prevent gynecomastia, optimize fertility, or fine-tune bodybuilding protocols. A close reading of...
  25. Nelson Vergel

    Methylene Blue Pros and Cons

    Methylene Blue Human‐study dosing at a glance Setting / studyRouteDoses actually givenExposure periodTypical body-weight equivalent*Key note 3-D human-skin model (Scientific Reports 2017)Topical cream/medium0.1 μM, 0.5 μM, 2.5 μM (≈ 0.00003 %–0.0008 % w/w)14 days dailyn/a0.5 μM gave the...
  26. Nelson Vergel

    Methylene Blue Pros and Cons

    DEEP DIVE: Methylene Blue as an Anti-Aging Intervention Introduction Methylene blue (MB) is a century-old synthetic dye and medication that has recently gained attention for its anti-aging potentialpmc.ncbi.nlm.nih.gov. Traditionally used for conditions like malaria and methemoglobinemia, MB is...
  27. Nelson Vergel

    High levels of antihistamine drugs can reduce fitness gains, study finds

    Really? I am going to try it. How much do you take? Thanks
  28. Nelson Vergel

    Methylene Blue Pros and Cons

    https://www.empowerpharmacy.com/compounding-pharmacy/methylene-blue-capsules/
  29. Nelson Vergel

    Methylene Blue Pros and Cons

    These scientific articles explore the anti-aging potential of Methylene Blue (MB), a traditional drug, for human health, particularly focusing on its effects on skin longevity and its broader implications as an anti-aging drug. Both sources, published on the U.S. government's National Library of...
  30. Nelson Vergel

    Medications that Can Impair Muscle Mass and Strength Gains from Resistance Training

    https://www.excelmale.com/threads/do-multi-ingredient-protein-supplements-augment-resistance-training-induced-gains-in-skeletal-muscle-mass-and-strength-a-systematic-review-and-meta.17940/
  31. Nelson Vergel

    Medications that Can Impair Muscle Mass and Strength Gains from Resistance Training

    Introduction Many common medications – both prescription and over-the-counter – can influence the muscle mass and strength gains achievable through resistance exercise. Some drugs impair or blunt muscle hypertrophy and strength development, while others enhance or exaggerate these gains. These...
Buy Lab Tests Online
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic

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