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Sirolimus / Dialing in the Right Dosage and Protocol
I would argue that this demographic is more likely to have chronically elevated mTOR for various reasons and, for anti-aging purposes, is more likely to benefit from reduced mTOR. IMO, the optimal dosage is likely unknowable given the hundreds of other variables involved, so for me, it's a...- Guided_by_Voices
- Post #4
- Forum: Health Span Extension Research
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PT-141 Appears to work great only when sleeping?!
Nor-epinephrine decreases during sleep which IIRC has a pro-erectile affect. I and many others have found that PT-141 seems to require sleep to fully "activate" it. Away from sleep, I have found PT-141 to enhance the affect of the viagra-like compounds, but not to be miraculous on on its own...- Guided_by_Voices
- Post #5
- Forum: When TRT Is Not Enough (ED, Libido, & More)
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Sirolimus / Dialing in the Right Dosage and Protocol
I have been taking 4mg every two weeks for the last several years. I haven't noticed any strength decrease that would indicate a problem with MPS, and I am stronger overall. Blagosklonny, the last time I heard him interviewed, said that he thought part of the mechanism of action was reduction in...- Guided_by_Voices
- Post #2
- Forum: Health Span Extension Research
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Seeking Advice on Best Peptide for Muscle Growth
I would start with DMSO. If that doesn't fix the issue (and not re-injuring the problem is essential) then BPC and or some form of GH secretagouge would be a good next step, as described above. 1-3 mg of BPC at a time injected close to the injury. I've had very good results with BPC patches...- Guided_by_Voices
- Post #7
- Forum: General Peptide Use & Information
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Tadalafil Use in Cardiovascular Disease
It seems to me that the benefits of tadalafil are sufficient that pretty much everyone (men and women) should be on a low dose past a certain age, whether it is beneficial for HF or not. Trying to figure out everything it benefits seems like a waste of money and time, given that it is about as...- Guided_by_Voices
- Post #3
- Forum: Health & Wellness
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Daily Cialis Plus Trimix?
In theory, the combo should be superior for overall health due to the systemic cardio vascular benefits of the Cialis class of drugs, even if the erection results are the same.- Guided_by_Voices
- Post #20
- Forum: When TRT Is Not Enough (ED, Libido, & More)
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Effect of Supplements on Endurance Exercise in the Older Population: Systematic Review
I use it (synthagen) but I suspect I use too low of a dose and with too many other variables to really give a good evaluation based on results, but the logic behind it looks reasonable. That said, I would not trust any other brand that I'm aware of. It is apparently faked and diluted quite commonly.- Guided_by_Voices
- Post #13
- Forum: Workouts & Routines
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Primobolan/Tren HRT No Test
Premature Ejaculation- Guided_by_Voices
- Post #22
- Forum: Clinical Use of Anabolics and Hormones
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Primobolan/Tren HRT No Test
It's also worth noting that Tren and Primo both apparently have a very pronounced anti-libido/EQ affect in some people. It's especially unfortunate as Tren is one of the very few compounds that help resolve PE for some people, although I think Nandrolone may as well.- Guided_by_Voices
- Post #10
- Forum: Clinical Use of Anabolics and Hormones
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Podcast about SLU-PP-332; GLP-1, GIP, and glucagon (single, double, triple) agonists; and SARMs
I ordered it on 2/16, so not too long ago. Also, I also appreciated your comment that Nandrolone increases synovial fluid and I refferenced you in one of the threads on here about that. That is a possible mechanism for reductions in joint pain that I had not seen before, but I'm far from an...- Guided_by_Voices
- Post #6
- Forum: General Peptide Use & Information
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Podcast about SLU-PP-332; GLP-1, GIP, and glucagon (single, double, triple) agonists; and SARMs
Welcome!!! I'm eagerly awaiting your book and look forward to your contributions. I am not on the other sites you post on (I am a believer in micro-dosing which seems to generate drama on some forums), but I do read and respect your work. I especially appreciated your reality check on Boldenone.- Guided_by_Voices
- Post #4
- Forum: General Peptide Use & Information
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Should I continue trt or not?
Since what I referring to is purely speculative and I haven't heard anyone else taking about it, doses and timing have to be guesswork. I don't remember what Dr. Denmeade's intervals are but I seem to recall that his dose was 600mg, although I could be way off. Anyway, if I was going to try the...- Guided_by_Voices
- Post #40
- Forum: Testosterone Basics & Questions
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My Melanotan 2 experience.
In my experience, that is a crazy-high dose. I would start at around 100-300mcg (micrograms) and gradually adjust high, but only if needed. This assumes you are looking for a bump in performance, not a wholesale transformation, in which case other options would be needed.- Guided_by_Voices
- Post #52
- Forum: General Peptide Use & Information
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Just had 1st CT Angiogram Scan done. Anyone experienced care to comment in simple layman terms?
It sounds like you are on a good path. The issue that jumps out at me is that Vitamin C is really important on many levels and likely at higher doses that most people get. If you take it away from high iron meals I wouldn't expect it to increase iron absorption since it is (as long as it's not...- Guided_by_Voices
- Post #12
- Forum: Health & Wellness
Beyond Testosterone Podcast
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