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  1. C

    Hesitating on TRT, Does Anyone Have Regrets?

    Unfortunately you're getting some mis-targeted advice—because primary hypogonadism is relatively rare. In some respects you are better off than those of us with secondary hypogonadism. Your malady is limited to testicular insufficiency, in contrast to the majority whose maladies involve poorly...
  2. C

    DHT: How High is Too High

    I assume it's highly dependent on both the dose and the individual. Though speculative, it's possible that taking Cistanche extract simultaneously would hedge against suppressive effects. The echinacoside in this extract appears to have SARM-like effects, blocking androgen receptors in the...
  3. C

    High SHBG, Low free T.

    Your free testosterone isn't extremely low, so it's borderline whether you should be characterized as hypogonadal. Nonetheless, there are at least some suggestions that very high SHBG like yours may interfere with androgenic activity. Therefore I wouldn't condemn you for wanting to experiment...
  4. C

    GHK-cu and DHT

    What dose size are you targeting? Going with 1 mg/mL is likely more concentrated than you want, especially if you're not using 0.3 cc syringes with half-unit markings. Suppose you're using 1 cc U-100 syringes and want a 2 mg dose. Then you'd be better off with the original dilutions you...
  5. C

    Lab results

    You heard wrong. The normal range for Vermeulen calculated free testosterone is about 7-22 ng/dL, with 13-17 being typical for healthy young men. I've never encountered anyone who is genuinely hypogonadal with cFTV greater than 10 ng/dL. You could be that rare exception, but it's more likely...
  6. C

    GHK-cu and DHT

    You can do either depending on what makes it convenient to take the intended dose. With 50 mg/mL you have 0.5 mg/unit in a U-100 insulin syringe. With 50 mg/ 2 mL = 25 mg/mL you have 0.25 mg/unit. I tend to initially mix 100 mg GHK-Cu with only 1 mL of bacteriostatic water, but my multiple 1...
  7. C

    Initiative Calls for Updated Standards in Testing for Suspected Low Testosterone

    “However, many commercial labs use an assay that purports to directly measure free testosterone, the so-called direct free testosterone,” Dr. Dunaif says. “This assay has been found to be totally inaccurate and should never be used.” @Dr Justin Saya MD, when is Defy Medical going to stop...
  8. C

    My blood test results on enclomiphene

    You have good numbers for being on a fairly low dose of enclomiphene. You're responding better than those in the clinical trials, where only the 25 mg cohort had really respectable levels on average.
  9. C

    High testosterone is like … finasteride? Say what!

    It is possible. Assuming the injections are comparable to Natesto, which is not a given, then that modest HPTA suppression combined with a little more from hCG might still allow for some LH production. It's probably a situation where different individuals could see different outcomes.
  10. C

    High testosterone is like … finasteride? Say what!

    When blending propionate with either enanthate or cypionate I found that getting half of the testosterone from each ester gives a diurnal variation in levels that is at the high end of normal, around +/-25% about the mean, or a 40% drop from peak to trough. We discussed a lot of the nuts and...
  11. C

    High testosterone is like … finasteride? Say what!

    No, they are more like Natesto. There's a rapid spike in levels followed by a relatively swift decline. As a standalone TRT method they would need to be used at least 2-3 times daily.
  12. C

    PP405 Possible Breakthrough Treatment for Hair Loss

    Still a ways off with the Phase 2A trial just getting started. If it continues to look good then it may show up on research chemical sites before FDA approval, depending on its legal status.
  13. C

    High testosterone is like … finasteride? Say what!

    Natesto has the evidence behind it. It's the only form of TRT proven to allow continued HPTA function, which in my mind makes it more physiological. Oral forms cause more complete suppression unless accompanied by a SERM. It's likely that appropriately dosed buccal troches would be similar in...
  14. C

    Dialed in on Testosterone Propionate, How to Switch to Cypionate

    It comes as 100 mg/mL, but I dilute it to 50 mg/mL for quarter-milligram dose resolution.
  15. C

    Dialed in on Testosterone Propionate, How to Switch to Cypionate

    Suspensions are water-based. In this case there are micronized testosterone particles suspended in the carrier; being hydrophobic they do not dissolve as they would in oil. The injections are spaced six hours apart. No blood work yet, but I am seriously considering doing a sequence of tests to...
  16. C

    Question about dosing.

    The slower the transition, the less the likelihood of side effects. If you limit the reduction to a few milligrams per week then you may not even notice it. But then it will take a few months to complete. With respect to anxiety, have you ever tested your serum progesterone? Frequently it is...
  17. C

    Question about dosing.

    If your goal is primarily to be healthy then be aware that the maximum testosterone production in healthy young men is equivalent to 90-100 mg testosterone cypionate per week, and 60-70 mg is typical. By this standard you are vastly overdosed. The long-term consequences of this are uncertain. We...
  18. C

    TRT in men in their Nineties

    Older men do get more "bang for the buck" from testosterone because the metabolic clearance rate declines with age. That is, free testosterone will typically go higher at the same dose as we age. There is no evidence that high levels of testosterone are healthier or to be preferred in any way...
  19. C

    Dialed in on Testosterone Propionate, How to Switch to Cypionate

    I agree that estradiol is the stronger regulator, but we typically observe that enclomiphene fails to stimulate the HPTA under conventional TRT. This is most likely due to the direct negative feedback of androgens on kisspeptin neurons in the arcuate nucleus. I've suggested that using cistanche...
  20. C

    WAS: 5 months post stopping TRT cold turkey bloodwork , NOW: Wife No Longer Wants Sex

    You have my sympathy. Having experienced something similar, I think people fail to appreciate the dramatic effects menopause can have on some women. It goes well beyond libido, perhaps affecting feelings of empathy and connectedness to significant others. Nominally my wife divorced me because I...
  21. C

    Dialed in on Testosterone Propionate, How to Switch to Cypionate

    It might work in some healthy individuals, but it's more of a stretch for those suffering from secondary hypogonadism, who have a reduced natural set point for testosterone. A crude estimate based on an 18 hour half-life is that propionate still leads to a trough that's 40% of the peak. I...
  22. C

    Effect of adding DHT gel to hCG monotherapy

    Your one measurement is already more useful than any guesswork I might provide, especially if we assume a fair amount of individual variability. To me it says that lowering the dose to 150 IU hCG EOD has a decent chance of reducing suppression to the point where LH is at least low-normal.
  23. C

    Female sexual interest drug reaches tipping point with Phase III plans

    Are you thinking that any potential return on their risky investment should be limited by your definition of fairness rather than by the free choices of buyers and sellers? That's been tried and it was a colossal failure.
  24. C

    Effect of adding DHT gel to hCG monotherapy

    That's highly dependent on the doses involved. DHT can inhibit aromatase, so at high enough levels there could be a noticeable effect on estradiol, but still nothing like a dedicated aromatase inhibitor. The dose of hCG also matters. At lower doses the HPTA may not be fully suppressed, implying...
  25. C

    Dialed in on Testosterone Propionate, How to Switch to Cypionate

    I think it's more a matter of semantics. It is true that esters slow the release of testosterone, and that once released from the esters the testosterone molecules are indistinguishable from others, regardless of source. I do not believe @madman is arguing that differing pharmacokinetics do not...
  26. C

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    At least in the past I recall that they used the ratio of testosterone to epitestosterone to reveal doping. It's stated that an abnormal T/E ratio can also be indicative of the use of exogenous DHT. Epitestosterone is an inactive epimer of testosterone that is naturally produced in equal...
  27. C

    Optimum IGF-1 Levels While on Enclomiphene

    Most men will have significant HPTA suppression with a TC/ENC protocol, making the enclomiphene not worthwhile. However, you can bypass the hypothalamus, where the significant negative androgenic feedback occurs, by injecting GnRH in pulses.[R] Another quibble is that 10-20 mg TC daily is hardly...
  28. C

    Open vial degraded after 6 months?

    Equilibrium dialysis is supposed to be the gold standard. Therefore if the test was done correctly then the results point against SHBG causing the variation in testosterone; free testosterone appears to drop in proportion to total. This leaves lab error as the most plausible reason for the large...
  29. C

    Open vial degraded after 6 months?

    Yes, impaired/slower metabolism leads to higher levels of testosterone, the opposite of what you're seeing. This is a good idea. It's useful to have SHBG so that you can calculate free testosterone from total using the Vermeulen method. The general expectation is for average free testosterone...
  30. C

    PT-141 Appears to work great only when sleeping?!

    https://www.excelmale.com/threads/a-different-dosing-strategy-with-bremelanotide-pt-141-yields-dramatically-better-results.28542/
  31. C

    Open vial degraded after 6 months?

    Nothing much happens to the testosterone, but carrier oils may degrade over time and be less healthy to inject. Underlying metabolism of testosterone is unlikely to change much in this time frame. It gradually slows with age, leading to higher testosterone at the same dose. In theory a...
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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