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  1. Gianluca

    Testosterone Cypionate vs Enanthate Ester break down

    @FunkOdyssey @Gman86 Have you guys seen a noticeable difference in labs going from Empower CYP to Hikma Enanthate?
  2. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    I will probably take the test in a week or two, and then I will update you guys here.
  3. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    Funny I was just looking into it last night, thanks for posting this. Ref range for adult males is ≤0.3 ng/m, I remember seen a study showing normal levels being <.9 ng, but wondering if the different assay leads to a different ref range.
  4. Gianluca

    HCG and Bacteriostatic water question ?

    @Vince do you think it is ok to reuse a bacteriostatic water btl even when the first time air was injected in the vial to draw the water out?
  5. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    @Cataceous what would you estimate is the peak time and half life of a 2.5mg ( 0.05 ml ) Progesterone Injection suspended in oil injected SC, considering its IM peak time is "within 8 hrs" at 10mg ( .2ml )?
  6. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    I thought I would use that spot because I already use the abdomen for daily HCG, but I always wondered if there is any difference in absorption between different SC spots for oily injectables. I'm no sure actually, my doc suggested to take it in the am since I was complaining of some sleep...
  7. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    SubQ on the upper outer quadrant of my butt. I now take it every am, 1mg dose. I still have to look at where to get my LC/MS for Progesterone.
  8. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    correct, I take a click of a Pregn cream once in a while but not all the time. I still want to try to include it on my protocol sometime in the future though.
  9. Gianluca

    Where to buy syringes, HCG, ED drugs online without a prescription

    I think this is really the most convenient place to buy insulin syringes, I can't find any better
  10. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    keep us posted, I may actually take the LC/MS as well, I think there has been some inconsistency with my Progesterone testing since the beginning as well
  11. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    anxiety and mood improved, some sort of fear of heights improved, I believe it improved my thyroid and adrenal function, better skin, erections sex drive and libido. I was hoping to see improvements in my sleep like other experienced in here, but I don't think I noticed anything in that regard
  12. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    I’m currently use an injectable, which I find it works the best, more physiologic as it doesn’t make that first pass in the liver. I tried oral micronized IR and SR, cream or forearm and scrotum, I felt too moody with this and groggy at times, likely due to excess allopregnenolone. There is...
  13. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    Interesting. I heard about the saturation for E2 and DHT with higher Test level before but never looked at the mechanism. The enzyme saturate, but doesn't "burn" as Mark Gordon mentions, perhaps in the brain it may be different. It is interesting to note also the saturation of the 5 ar start to...
  14. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    I agree. In fact if injecting more Testosterone would "burn 5 alpha reductase" we would see a drop in DHT as well, but not quite I believe. On TRT, Progesterone needs to be monitored, and supplemented to raise levels. I don't know why this is not common practice for practitioners out there...
  15. Gianluca

    Trt options in men with BPH

    How is your Progesterone level?
  16. Gianluca

    Testosterone Cypionate vs Enanthate Ester break down

    I’m picking up my Test E from Hikma from CVS pharmacy here in LA. I will switch from TC empower in a couple of weeks when I finish the vial. Good talk in this thread @FunkOdyssey about the preservatives in T formulation, I will give an update once I’m starting the TE
  17. Gianluca

    Testing for Copper/Zinc

    since then, I changed my diet a little bit, . I started to eat more red meat and including beef liver weekly for copper, but I have never followed up with my copper level Serum copper it is not a good maker for copper status in the body. Testing Ceruloplasmin is a better way, perhaps along with...
  18. Gianluca

    Testosterone Cypionate vs Enanthate Ester break down

    @FunkOdyssey @Gman86 are you guys still using the Hikma Test E from Defy? I just checked their website and 5ml vial is $199? it seems way to much $ for 5ml test. Same brand can be found at CVS for $ 94 regular price, or $32 with Goodrx
  19. Gianluca

    Issues with Empower Test-CYP?

    I hear you. I ask Defy if any of the pharmacies can compound a Test in MCT oil but nothing, not sure why it is so hard to do.
  20. Gianluca

    Issues with Empower Test-CYP?

    I think that’s ok for Empower to sell big pharma test, I’m in Cali and they can’t send compounded test here, so that is an option for us. I’m guessing people in other states have same issue.
  21. Gianluca

    Issues with Empower Test-CYP?

    @Gman86 Why Enanthate over Cypionate? Is it the carrier oil?
  22. Gianluca

    Giving Testosterone in Cottonseed oil a try?

    What carrier oil are you using now?
  23. Gianluca

    Giving Testosterone in Cottonseed oil a try?

    thank you!
  24. Gianluca

    Giving Testosterone in Cottonseed oil a try?

    that is a good point, I inject everyday so the cottonseed may not be a great idea.
  25. Gianluca

    Giving Testosterone in Cottonseed oil a try?

    Hi Guys. I have the chance to pick up some testosterone brand name in Cottonseed oil. I have been either on grapeseed oil or sesame oil. I believe reading back years ago many had issue with Cotton seed oil? since then I thought this was the worst oil possible to use
  26. Gianluca

    The Tryptophan Steal - The Hidden Reason Stress Makes You Depressed

  27. Gianluca

    If endogenous thyroid peaks at night/early am, why do we take exogenous during the day?

    You only take one dose of Thyroid in the am or dive it throughout the day? NDT I would think
  28. Gianluca

    If endogenous thyroid peaks at night/early am, why do we take exogenous during the day?

    Are you taking NDT?
  29. Gianluca

    If endogenous thyroid peaks at night/early am, why do we take exogenous during the day?

    According to this study, Thyroid level are at the highest between 10pm and 10am, why then everyone takes it during the day? wouldn't make sense to take the first dose at night before bed, and second right after waking up? I may want to try this actually. Free Triiodothyronine Has a Distinct...
  30. Gianluca

    Permanent side effect from Pregnenolone?

    The Side effect still have to disappear. Preg can increase color perception, I don’t think the issue is any of the ingredients in the cream
  31. Gianluca

    Losartan vs Telmisartan

    are there any withdraw symptoms from Telmisartan or Losartan? @Nelson Vergel
Buy Lab Tests Online
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic

Beyond Testosterone Podcast

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