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Binding affinity for AR Binding of T and DHT to the androgen receptor (AR) stabilizes the AR and slows what would otherwise be rapid degradation. At low circulating androgen levels, DHT binding is favored over T but at higher relative T concentrations (e.g., eugonadal state), stabilization of...

Figure 1. Metabolism pathways for deactivation of DHT to inactive glucuronides. Enzymes and genes associated with pathways are noted next to arrows. Relative thickness/size of arrows represents primary direction of reaction. Compiled from (6, 7, 8). 3α-DH, 3α-dehydrogenase; 3β-DH...

DHT is the 5α-reduced metabolite of testosterone (T) that is principally converted from T in target organs such as prostate, skin, and liver. Synthesis can also occur from other precursors, but these pathways, although potentially important in some tissues (e.g., in prostate), are minor...

I have recently resumed using topical DHT. It has been a few years since I have last used it and the concentrations are now higher than before. Naturally, I was curious as to any implications this may have on prostate health. Research has uncovered some fascinating information...

Fatigue and low energy are some of the most reported ailments people suffer from. Due to the large number of reasons that a person may have these symptoms, it's extremely difficult to pin the root cause down. As prevalent as this virus is, a person reporting these symptoms should be tested for...

The MAJOR factor for success in taking LDN is getting proper sleep, I mean DEEP sleep. The drug works while you are sleeping, any disruption of your sleep cycle will result in the symptoms you mentioned above. If you have to, take something to help you sleep through the night. Interestingly...

For clarification, the discussion of selegeline is on topic with this thread as it is a potential solution to the problem... ;)

Some things that potentiate the effects of selegeline for me in a negative way are stimulants. Caffeine, energy drinks, tyrosine and others have to be moderated or I get overstimulated.

I am fortunate enough to have an open-minded physician who has prescribed me selegeline. It's worth a shot for any who are interested to ask your doc for a script. Take your research in and show them, do your homework and know that this is a small dose that will not effect MAO-A. If they...

I personally take a 5 mg tablet daily. Some are using a liquid form from what I have heard, but there are conflicting opinions on that. A good description of the benefits is here: https://www.antiaging-systems.com/articles/deprenyl-50-years-of-life-enhancement-and-life-extension/

The dosage for health extension purposes is very low, 2-5 mg's. I have seen no reports of any ill effects after discontinuation.

I have stopped selegeline in the past several times with no ill effects.

Selegeline does not increase dopamine levels directly, it acts on the enzyme that degrades dopamine which keeps it active for a longer period of time. I have seen nothing to indicate that it has any effect on norepinephrine. The main thing with selegeline at low doses is that it only has an...

P5P is vitamin B6, 5HTP is a serotonin enhancing supplement, very different. Wellbutrin does indeed disrupt sleep in some as it can greatly enhance the action of norepinephrine. Agitation and anxiety are common, and dose dependent. I could only tolerate 150 MG of the extended-release tablets...

I have had similar experiences with Wellbutrin (Bupropion), although somewhat short lived. Wellbutrin works mainly by limiting the reuptake of norepinephrine and to a lesser degree dopamine. Both are crucial for orgasm. Not everyone responds to this the same way however, some experience anxiety...

With sincere respect guys, this discussion has gone south of the OP's original topic. It's great information, but the conversation has drifted. The point is loss of feeling during ejaculation. This is an important topic to a lot of guys, so if we could... please stay on topic.

Take a syringe and pump a bit of air into the vial. If you have a larger mixing syringe, use that. Not too much though or you will end up with the plunger getting launched when you try to fill the syringe.

Not thinking he is a liar, just mistaken as to growth VS increased penile function from increased DHT. Just keeping it real so this conversation doesn't turn into a Reddit rabbit hole...;)

1%? Highly doubtful that strength would have any effect. DHT cream increases erectile response and libido. The girth gains reported are likely from an increase of blood flow due to the libido increase which results in a fuller erection (as was stated above by other contributors to this thread)...

Excel does not sell any kind of drugs, medications or steroids. DHT is not available in the US other than UGL and other out of country sources.

Strong erections and a good libido are an indication that it's not likely a testosterone issue. I am assuming your libido is still good? Ejaculation with no orgasmic sensation could be caused by many things. Alcohol consumption, certain medications, nerve damage, porn addiction and excessive...

I have never heard a single good experience with pellets. They are more suited for an old guy who is no longer active sexually or physically and just needs to have an easy source of T.

Some updates... Major libido bump (I found it somewhat distracting today while trying to work), facial hair and body hair are growing faster and courser, better mood! I got all of these benefits before with Andractim, but the 10% definitely kicks it in to a higher gear.

I saw that product, I hope it's legit. Be prepared for a libido bump if it is ;)

I saw pictures (not vouching for authenticity) of an increase in length. I'll track it down and post a link.

The multiple wildfires in the West are causing a lot of smoke to linger. This has me blown up with allergy symptoms. My eyes are swollen, sinuses are a wreck, bronchial congestion and an overall crappy feeling. I was contemplating getting an allergy shot, but it appears that they aren't doing...

NAD+ is available from multiple peptide sources without a prescription. Here is a link to a reliable source. The owner of the company is also a member here: https://nusciencepeptides.com/product/nad/

The protocol I have read about for enlargement is applying it to the entire penis twice daily. I am not going to do that. I apply it once daily after my shower to the entire penis followed by vitamin E oil. There is no irritation. I don't apply it anywhere else. You DEFINATELY want to wash it...

I am personally of the opinion that the anecdotal evidence of the effects of DHT on the clitoris are pretty much inarguable. Most people may not realize just how much alike males and females really are. This a very basic and easy to follow example...

LOL! No!!!!!

These studies are on children still developing. They don't translate well for adult males. That being said, there are people using DHT cream at 10% who report a size increase in their penis. Everything is anecdotal, no studies exist as to the efficacy of transdermal DHT (or testosterone) with...