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I always find a person that has had a strong family history and personal history of a very specific problem prior to testosterone then associate it with getting testosterone. So let's be real clear you have a history of migraines and have had migraines for many many years prior to getting...

Manipulating those said hormones are worthless. Both injections and the cream raise DHT levels. There is more five alpha reductase in the scrotal skin so it's going to convert more of the testosterone to DHT. But that does not mean the target tissues have higher DHT levels because they don't...

Your question is a very good question and exactly the type of questions they get asked on forums The problem is that the answer from the forums always has to be always somehow, hormone related. The answer to your question is much more complex and that is why when you are working with a provider...

The desire to help and stop the continued misinformation but it only takes about a day or two to realize you can’t help those that don’t want to understand the actual science so then you stop trying again. Like now. Got it out of my system and now back to work

Do you really believe what you just wrote? That the body actually lowers it as a protective measure? Give us one instance where that occurs naturally. You are writing a typical forum response that is not based on physiology or the medical literature. This is the exact problem with forums. The...

I also personally don’t understand anyone that “struggles” on testosterone. Did you struggle when you were younger and had good testosterone levels? If you didn’t then why are you struggling now? If it is done correctly you should not struggle now any different than you struggled when you were...

Studies giving man transdermal DHT for 24 months exposing them to exceptionally high levels of DHT did not result in acne, male androgenic, alopecia, or other skin pathology. Target tissues have local homeostatic control mechanisms that tightly control DHT concentrations. So circulating levels...

Testosterone goes down three pathways, whether you make it or take it. It has a direct effect on muscle tissue, and everyone knows that increasing testosterone levels increase androgen receptors as they are auto regulated in muscle tissue. But what we’re talking about is a different situation...

Really? Since DHT is over the counter in some countries and we have multiple studies raising DHT by factors of 10 and yet they get none of the symptoms that you complained of. Are you trying to associate the increase in DHT from testosterone with the use of anabolic steroids? That’s an apple and...

Sorry that it sounds like an oversimplification, but it’s just the facts and the physiology.

Before you comment, make sure you understand the physiology of androgens, as well as DHT etc. I’ll be glad for you some literature on DHT so do you understand that at target tissues the receptors are fully saturated at a low testosterone level. Take a look at Morgentalera saturation model.

Correct and very excellent post

You also have the DHT all wrong. Why can it not be the Aromatase inhibitor being a medication with side effects that caused your problem? Why is it DHT? The DHT receptors at the tissue level are fully saturated at a fairly low testosterone level (250ng/dl in the prostate for example) What you...

Best post I have read in a long time. You are correct on all points. Congratulations!

When you increase testosterone, you will increase its active metabolites. It’s just pure physiology.

You should've discussed with your provider about why your levels dropped. There are multiple reasons this can occur and he should discuss that with you and make the appropriate adjustments. Timing of labs will make a difference. Shaving or not shaving before your labs will make a difference...

It seems you're doing the best to complicate something that is totally uncomplicated. You can apply the cream anywhere that you have skin. Literally anywhere (face, shoulders, neck, chest, legs, etc...). You can achieve success or good levels applying it anywhere it's just a matter of finding...

I would ignore him. Equel is the village idiot

because there is a saturation point in the tissues. So yes cream will raise DHT levels higher than injections but there is a saturation point. Once that saturation point occurs raising DHT any further has no effect. The prostate saturation point is at a really low testosterone level for...

Studies of > 400? How about 700? "In all of these studies, DHT treatment resulted in sustained increase serum DHT to high supra- physiologic levels of DHT [e.g., in the range of 700 ng/dL for up to 24 months " Well first and foremost you have to understand the physiology and that DHT is a...

Oh but it has. Read article. Its also a paracrine hormone

Its okay to be wrong

Did you ever think to just apply less so your levels didn't "skyrocket"?

Yes is does and that’s why it’s called a “piss hard on” Go back and review anatomy and physiology before you post

Wow really. You mean long term like for decades? You mean like the decades Testosterone has been used and hasn’t been shown to cause this? Like Rouzier says there might be a man on Mars but there’s not but people will say there might be but guess what there’s not. You can continue To try to find...

Everyone knows who you are Joseph Hearnshaw

Not wanting to open up that can of worms but Dr. Sayas Concerns are not based on current medical literature. There are 3TRT myths that are continually propagated. The first myth is that it causes prostate cancer. It is also a myth that it worsens prostate cancer in men with prostate cancer. The...

You should be able to get a refund and use the money towards treatment. For the most part all clinics offer free consults and telemedicine including Dr Nichols

Have you through about just seeing Dr Nichols yourself? Dr Howell is a wealth of knowledge in androgens but doesn’t have the ability to treat Why not just set up a free consult with Rouzier or Nichols and problem solved

All measurements are done via ultrafiltration. A HRT bases use But several bases will work well. HRT works great and to be used for men and women. We don’t find a need to measure SHBG since we are following symptoms first and foremost along with free testosterone. Free testosterone is measure...

That is Just one lab example there are hundreds of lab examples which run the gamut from much higher than that ito lower than that. Each man responds differently with regard to absorption, consistency of application, consistency of shaving etc…so it is individualized to each patient. We are...