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We do know for sure what elevated DHT in the serum does long term. What you should be saying is that you want to ignore that. We can't get away from basic bio chemistry and physiology. DHT sensitive tissues have a control mechanism that tightly controls intracellular levels.

The individual has a choice. You're blaming it on estradiol but it's not. It's just a surrogate number that you're following but when you take testosterone and raise levels and levels of estradiol, testosterone, and DHT, along with serotonin and others etc. What a man's levels get too high too...

Everything you have posted is a baseline study. It has nothing to do with raising estradiol by giving testosterone. In every study that mean we're giving testosterone get raised estradiol (unless it was a study where they were blocking estradiol). In all of those studies where they gave...

Women are dying every day aren't they because their estradiol gets above 96 right? You keep thinking all you want that it's dangerous and that you should control estradiol. You just keep thinking that because it keeps me really busy repairing the damage from men following that type of advice or...

I don't see testosterone causing blood pressure to go "out the roof". People make adjustments based on short-term issues that resolve over the long term. When a man gets optimal levels fairly quickly with testosterone in certain instances there's going to be some fluid retention because usually...

I don't believe in throwing oxandrolone in the mix. That's not to be disrespectful but it's because it's not a part of True bio dentical hormone optimization. Honestly outside of true muscle wasting diseases or burn victims etc... I haven't seen the need to utilize an anabolic steroid. When...

Estrogen...

Please read up on your physiology before you post. Can produce same for estradiol if you want but you should have it and know it already right ?

No need....we will all take your years of clinical experience that testosterone is dangerous. Also, baseline articles in men not on testosterone have nothing to do with men on testosterone.

"you were feeling pretty great" and had great numbers. No matter what some others will tell you there is no harm with your numbers. There is no harm with your E2 at 96...none. You should have left everything as is and you would have continued to feel great. Once again another doctor that doesn't...

Quit giving bad advice on forums please!!!!! You are about to be a topic of a bad advice forum video

I have no idea what you learned all this about the cream but you couldn’t be more wrong. Once again, absolutely ridiculous what you are writing and saying. You know nothing about the cream and it is obvious. You really should not be giving advice on forums. Most of what you just wrote about the...

Totally ridiculous. 10 seconds twice a day is not an inconvenience and if it is then you don't have a real problem or too lazy to take actually 20 second a day. You don't have to wait for anything to dry rubs right in because it's in a vanishing cream when we use the HRT base. If you spent just...

You being a patient of Dr. Says explains why you don’t know anything about the cream and have so many questions. Shouldn’t you be posting your questions to Dr. Saya himself instead of on forums?

I don’t recommend an anal application for you because it increases the risk of transference and you wouldn’t want that

Let’s answer all of your questions. First and foremost identify yourself because after this response, you’ll get no more response from me because you’re a nobody until you identify yourself. First and foremost what’s your medical training and your background? I know it’s not very much, but...

Lets just ignore all the previous studies shall we read a lot?

Your lack of clinical experience shows every time you write something. You have no medical training and it shows every time you write something. You might be able to impress the little boys on forums but no one else. Like I've said before you might be some teenage boy living in Indonesia...

I know you were at the Androgen Society meeting but you must've been in the restroom or getting some coffee when this retrospective data mining study was discussed. It's not worth the paper it's written on. These retrospective studies cannot determine causation they can at most suggest an...

You Don't even realize that what you posted isn't a study do you? We discussed Ramasamy in the video if you would take the time to listen and if you did you would actually learn something. That was a retrospective data mining study. Just like the vigan and finkel studies. Absolutely...

Reason that is what we've been saying for the years and what is become a problem on this website which is the woke TRT movement. When you only give me an a little bit and then the study they only raised it to 750 or less than most men are not gonna do any better and they're going to drop out. If...

When you take the time to actually read the study and the details you'll see that 52% was just the highest that they got. If you would've gone higher than that they would've used a different number but that's the highest hematocrit they got on the dose. They didn't stop there it's just as high...

Seems like you spend a lot of unnecessary time pontificating on the cream. Use index and middle fingers to apply to scrotum and then wash hands. It should rub in all the way and disappear like lotion. You should wait at least 5 hours after applying for sexual activity, or wait until after...

As I always say read a lot understand little. That's our name for you inside our circles. The woke TRT movement is in full affect with you read a lot. I guess you missed the part where we talk about the beneficial effects that testosterone has on the vasculature. You can't use baseline studies...

This can happen if a person does not take the required steps to avoid transference. It is actually much more common when a man applies a topical solution to their chest and shoulder area. The scrotal application eliminates any risk of transference to children and animals or at least it should...

Your DHT is going to go up no matter where you apply the cream but there is more five alpha reductase in the scrotal skin than other areas. So yes the DHT that you will measure will be less applying to skin that has less 5 alpha reductase. But what do you measure is not what is at the tissue...

Cooper, testosterone works no matter if it's given via injection or cream. They both work if someone knows how to provide it correctly

Yes, the scrotal application is used for two reasons. Reason number one is that it is the best site for absorption with regard to skin. It is thin skinned and highly vascular and you can get up to eight times better absorption than some other areas. You can apply the cream anywhere that you have...

When the creams applied daily the levels are very consistent and from the peak after application to the second application there's only about a 25% drop. So levels stay very good 24/7 with constant application. Unless you're doing a daily injections you can't really compare free testosterone...

I'm traveling so I'm limited with what I can get done but let me be a little more specific. If I were treating you I would first and foremost tell you that we are going to have to work with the hand that you have been dealt. Unfortunately we sometimes have to work within some constraints. You...

Most men that are on injections only raised all levels a little bit. When you raise your levels a little bit you raise DHT a little bit. The cream raise DHT much more for any given level of testosterone therefore it can have a better effect on libido and sexual function. But if you give a man...