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5-7 180lbs - but even when I weighed 20lbs less, my BP did not lessen. Have tested my DNA extensively for hereditary clotting issues and nothing came up except MTHFR. I feel I need be on TRT at this point and think I should d/c the Metformin for now until my T levels are optimized. Maybe start...

low 100s if I don't fast for at least 12h, in the mid to high 90s if I do. If I eat even complex carbs for dinner, FBG will go into the 110-115. A1C 4.9-5.2. Metformin doesn't seem to influence those numbers either way. I take 1g with last meal and 500mg before sleep.

Observations being on ER-Metformin for last 4.5 mos. (started July 1, 2022) 15lbs weight loss - no change in diet or training No GI problems up to 2g/day No change in fasting glucose levels or a1c (not diabetic to begin with) *Substantial decrease in total and free T (not on TRT): June...

Yes.

Observation - Progressive increase in blood pressure/pulse averages: last 12 mos: 127/79/63 last 6 mos: 126/80/64 last 3 mos: 128/82/68 last mo: 131/84/67 causes: increasing NDT>increased serum T3 = elevated BP/pulse?

Have been doing it before for the last several labs this year to measure the effect of the dose.

When you say to keep your FT3 levels high, how high? I, too, have lately been doing my labs the same morning I take my NDT dose to see how the medication is working. And it is working as I can tell from the labs I posted on above. I guess I shouldn't be concerned with being a bit over range on...

That one relates to TSH over-suppression. Fortunately, not my problem. In fact, my issue has been high normal TSH and trying to suppress it more by gradually increasing the dose of NDT which it appears I have done. That latest level of 1.23 is right around where I need to be.

Didn't get rT3 tested this time, but I usually hover around 19 (but that was at a lower dose of NDT). Will test again soon. What I really am curious to know is whether too much T3 can accelerate cartilage degeneration which would give rise to OA and injuries. Maybe it's completely unrelated...

Never have had an indication of Hashi's from dozens of past labs and ultrasounds and as I indicated, I am on NDT, not Synthroid.

Latest labs (last dose of 2.50 grains (162.50mg) NDT taken only about 6h prior to draw): TSH:1.23 ref range: 0.450-4.500uIU/mL FT3: 5.00 ref range: 2.0-4.4pg/mL FT4: 1.60 ref range: 0.82-1.77ng/dL Anyone notice that too much T3 from desiccated thyroid causes a flareup in joint pain? Is a 5.0...

My 4-month trial of Metformin (1.5g) proved me right: For all the wonderful health and ligevity-enhancing benefits, I' experienced a 36% drop in total testosterone since starting which I knew about and several studies have shown. I was already low normal (high 400s) which was not optimal, now am...

I am 99% certain my high normal (for my age of 62) of 258 is from eating a diet in which my protein is mostly all from non-plant sources (cultured dairy, eggs, lean meats, fish, poultry, whey) + supplements like DHEA + training. I prefer this type of protein over anything plant-based. This...

Anyone have data showing that if one's natural IGF-1 level is high normal for one's age as in my case (see below), would GHRH/GHRP peptides be contraindicated since they raise IGF-1 over time? The concern is not as bad as with straight GH, but is still an issue for long-term (cancer, CV disease...