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If your free testosterone measurement is reasonably accurate then the implication is that the high androgen load has driven your SHBG to a low level. This in turn has reduced testosterone storage capacity, and thus total testosterone. Under these conditions total testosterone in isolation has...

Your free testosterone is 180% of the top of the reference range and you want to reduce by only 20%? A dose that mimics healthy natural levels is going to be more like 40-60 mg TC/week in your case. More is not better unless building muscle trumps all other health concerns. The forums provide...

It looks as though your free testosterone was calculated with the Vermeulen method, which is good. However, I think their normal range is a bit optimistic. Your level is about where I would put the cutoff for normal and healthy, so I think it is possible to have issues there. That said, I would...

You didn't get an answer to the question. Maybe you phrased it differently? When I asked it refused to give a percentage. Instead of a percentage, here’s a more nuanced understanding: Incomplete Utilization: It’s safe to say that some percentage of injected testosterone cypionate will be...

While superficially it is a plausible hypothesis, you could make the same argument for injections and topical testosterone. Especially with IM injections, you could suggest greater release during activity. The skin acts as a testosterone reservoir for topical testosterone. Mightn't increased...

There is a possible intermediate step before dropping TRT altogether: You could run a trial for a few months with a testosterone nasal gel, such as Natesto. Over time this will allow your HPTA to recover. It will provide robust daily peak testosterone, while lowering average levels, which might...

Summarized nicely by @FunkOdyssey: "I would rank pellets dead last among all possible TRT modalities. The 'locked in for months at a gradually waning dose with zero control over my experience' concept is a showstopper." They can be expensive. The implantation can be painful. You can develop scar...

I'm not alone in considering pellets to be one of the worst forms of TRT. Mainly they are a good income source for the doctors implanting them. An average of 1.25 mg testosterone per day is much too small. The average natural production for healthy young men is 6-7 mg/day. When you were...

In this case it means that when a sufficient amount is available then it will be used preferentially. Contrary to your implication, glucose is so important that ketosis is maintained through evolution to prevent excessive depletion of glucose. Ketosis is an emergency backup system, not the...

Anastrozole is much less soluble in water (0.5 mg/mL at room temp), and unless you add some other preservative you'd probably want to refrigerate it to slow microbial growth. This would further reduce the solubility. With vodka you can safely store it at room temperature for long periods.

Each XYOSTED autoinjector contains 50 mg, 75 mg, or 100 mg of testosterone enanthate dissolved in 0.5 mL of sesame oil providing three product strengths of 50 mg/0.5 mL, 75 mg/0.5 mL, and 100 mg/0.5 mL. [R]

It is absolutely debatable, and you are overstating things. Under normal physiological conditions the brain primarily utilizes glucose for ATP generation. However, in situations where glucose is sparse, e.g., during prolonged fasting, ketone bodies become an important energy source for the...

It's possible, since it will reduce estrogenic feedback at the pituitary. Of course changing multiple variables will complicate interpretation of results. That's the key question here. I haven't come across any reports from RMC users where we might learn about other parameters. Is testicular...

Yes, you need to measure around 30-60 minutes post-injection to catch the LH/FSH pulses. At least this delay worked for me with subcutaneous injections. Some research data showing the timing of endogenous pulses: https://www.slideshare.net/slideshow/lecture3-30853796/30853796

While it's tempting to say yes, your isolated large doses are more in line with what Royal Medical Center was (is?) doing, and their published results suggest that significant—but probably single and isolated—LH pulses can be seen post-injection, even without SERM use. However, at least some...

The perineum (pl.: perineums or perinea) in placental mammals is the space between the anus and the genitals. The human perineum is between the anus and scrotum in the male or between the anus and vulva in the female.[2] The perineum is the region of the body between the pubic symphysis (pubic...

This sounds a lot like the honeymoon period I had with propionate. It lasted a week or two. I had a similar experience with bremelanotide, though shorter. It will be interesting to see if your results are sustained for a longer period.

https://www.excelmale.com/threads/a-different-dosing-strategy-with-bremelanotide-pt-141-yields-dramatically-better-results.28542/

Making it seem even more likely to be a lab error or some dosing issue instead of a 50% increase in free testosterone caused by a very large change in liver metabolism.

Some of us have found this to be the case. When I dose such that testosterone is highish or rises early in the night, sleep quality and duration are degraded. Switching to—early morning—injections of the aforementioned TE/TP blend resolved the issue, giving me an extra hour of quality sleep, on...

With a longer ester such as cypionate, you can't come very close to a natural pattern of testosterone levels, regardless. With frequent injections, levels are almost flat, having minimal variation. With infrequent injections, there are relatively large variations taking place over days. In...

Contrary to popular perception, this is a mid-level dose, providing more testosterone than most healthy young men make naturally. Therefore it could easily be too much testosterone for your physiology. The low SHBG and high free testosterone are suggestive of excess. Ask yourself whether it...

That clause has to mean that you wouldn't simultaneously receive TRT from elsewhere. It would be extremely unreasonable to deny you other avenues of treatment. But in the worst case you would need to find a new PCP, which would surely nullify the agreement. However, I'm no lawyer, so if you want...

Testosterone overdose. E2/T ratio on the low side.

Here's one study for starters. You can also follow the references. In this case the dose range was 3-15 mcg every 90 minutes. Results compared favorably to hCG/hMG therapy.

Of course delivering GnRH (gonadorelin) in pulsatile fashion via pump is already an approved treatment option for hypogonadism. I'm not sure if kisspeptin delivery needs to be pulsatile as well. If so then it seems likely that the frequency should correspond to that of GnRH. One study found that...

I assume you mean to say you have secondary hypogonadism, which applies when there's dysfunction at the hypothalamus or pituitary. Primary refers to testicular dysfunction. If your problem is with the pituitary then kisspeptin or gonadorelin wouldn't be of much use. However, hypothalamic...

I see essentially no change in cFTV based on averages, using 4.3 g/dL for albumin. Order: Baseline -> KD SHBG: 25.0 -> 31.2 nMol/L TT: 18.2 -> 20.2 nMol/L cFTV: 0.449 -> 0.452 nMol/L FAI: 72.8 -> 64.7 Using FAI as a proxy for free testosterone seems like a poor choice in 2024.

You're probably operating under a misconception. Research so far supports the proposition that testosterone esters, e.g. testosterone cypionate, are essentially inert until they reach the bloodstream. Only there do they make contact with enzymes that cleave the testosterone from the ester to...

Thus far, testosterone nasal gel, e.g. Natesto, is the only form of exogenous testosterone proven to allow continued natural production and retention of fertility. There's speculation that buccally-applied testosterone may yield similar results.

Hardly. Too much time playing Wordscapes. I think "altodare" has a nice ring to it.