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These drugs are going to change the world (once they're cheap enough for normal people to use!) Inclisiran is a PCSK9 inhibitor (NOT a statin!), but works differently than existing PCSK9 inhibitors and only needs to be injected twice a year: PCSK9 inhibitors are incredible. They aren't...

I'm curious about your case because I spend a lot of time studying lipids / CVD. Would you mind posting your lab results? You say you did advanced lipoprotein testing, etc. In particular, if you have any of these: * LDL-P / HDL-P - NMR lipid panel, if done * Apo B, Apo A-1 * Lp(a) *...

From what I understand, many of the health risks of deca aren't necessarily due to poor lipids, but things that aren't likely to show up on a standard blood test. I'm thinking cardiac fibrosis, LVH, and increased LDL oxidation. So OP, please realize that the normal blood tests won't tell the...

Do you have historical labs? Do you know what your testosterone, estrogen and SHBG were in the past?

I use a much cheaper (and less fancy) device, which is similar to this one: Robot Check I've used it to "check" myself for sleep apnea. It's obviously not good enough to actually know, but I don't have any symptoms so I wanted to see if my SpO2 was dropping during sleep. What I do is...

Some other studies linked here: https://www.reddit.com/r/steroids/comments/5kmur7/nandrolone_and_the_risk_of_left_ventricular/. Note that the dosage used converts to around 455mg a week according to this comment (https://www.reddit.com/r/steroids/comments/5kmur7/comment/dbpga50) My bro...

Benefits can be weighed with risks. In the case of muscle wasting, etc, these benefits may be worth the risk. In the case of nandrolone, the risks (IMO) have to do with possible cardiotoxicity. Nandrolone increases the oxidiation of LDL particles...

I don’t have the time or energy to debate what is likely one of the most well established facts in modern medicine here.

I haven’t used that spreadsheet before but I have used the site SteroidGraph - Graph your cycle, which does something similar. You might want to check it out as well. It’s designed for anabolic steroids users but you can use it for TRT as well.

I realize this is an old post, but one thing you might want to look into is absorption of plant sterols. Some people are hyper absorbers of the sterols, and they can cause atherosclerosis: http://www.onlinejacc.org/content/accj/47/7/1496.full.pdf

A bit confused by your numbers here. This is LDL-C if 123? You mention particle number, did you have that measured and what is it? LDL-C is not the particle number. If all you have is the standard lipid panel, non-HDL cholesterol is a good number to look at. Diet can definitely lower particle...

This is complete and utter nonsense. I’ve been researching CVD for 10 years (since my father got sick). This forum, like many places on the Internet, is extremely biased against statins and in general the idea of fixing your poor blood lipids. Please be careful taking advice here.

Magnesium glycinate caused weird anxiety in me. It was the weirdest thing. I was taking 800mg a day in divided doses, as recommended by my doctor. Apparently some people react poorly to very high doses of glycinate. I switched to citrate and no issues. Weirdest thing. May have to do with this...

Damn, I was having such a nice day so far!! I'm trying to figure out what's going on here. According to Biosimilar Development, Review, and Approval, it sounds like there's a relatively new (2009?) pathway for 'biologic' products to be FDA approved. What's potentially changing here? Was this...

At 20mg/day test-e subQ, 150IU HCG EOD I am at 952 ng/dL, 42.3 SHBG, 17.5 pg/mL (Labcorp range 5.00 - 21.00) direct free T, E2 sensitive 40.4 pg/mL, E2 standard 47 pg/mL. One month into TRT on 120mg/week, 250IU HCG twice a week, I was at 48 SHBG, 18.7 e2 sensitive, 30 pg/mL e2 non sensitive...

Interesting. As an additional data point, here's some plots for me over the past year: (I'm not sure how to make my graphs as fancy as yours)

For anyone considering using a SARM for muscle gain purposes, please understand the cardiovascular risks (relative to some steroids) may be understated:

I had lumps and soreness for the first month or two when I was doing subQ. Eventually I sort of learned the tricks of how to go in at the correct angle and depth to avoid soreness or lumps. For me, I started visualizing where the fat was under the skin and that helped. I even watched videos and...

While the TruT model gives more accurate predictions in the majority of the cases, there are still points where the curve doesn’t match the plotted points. So while pointing out examples of where men on the forum have ED matching TruT shows the model works for the majority of cases, it seems...

You’re picking a fight and putting words in people’s mouths that aren’t being said here.

I mentioned this in another thread, but I don’t see it being possible to accurately compute free testosterone from just SHBG, albumin and total testosterone. We know that there are other things that affect SHBG <-> testosterone binding, such as magnesium: The Interplay between Magnesium and...

Whatever man, go somewhere else with your obvious trolling

Absolutely, yes. I have the utmost respect for Dr. Thomas O’Connor. I don’t think you know very much about him. I’m sending my stepfather to him soon. He doesn’t prescribe anabolic steroids or something, his trade name was for when his practice was focused on helping men on anabolic steroids...

This is really interesting, thank you for sharing it Larry. I’d love to hear from anyone else who’s had their Dialysis method free T measured! For me, the Vermeulen method (classic free T calculator) matches my “direct” free T assay almost always, for what that’s worth.

You come here to pick a fight or something? There’s a less antagonistic way to phrase what you’re asking. The assessment of hypogonadism should take into account more than just total testosterone. As I’ve learned from this forum, the “free testosterone” assay is not accurate. So calculating...

What’s the source for this quote (study, paper etc). I can’t find it anywhere.

Another possibility RE: E2, which I’ve maybe commented on here, is that HCG produces DHEA, which can turn into Androstenediol. This isn’t “E2” so it won’t show up on a blood test, but may create E2-like symptoms: “Androstenediol possesses potent estrogenicactivity, similarly to DHEA and...

Based on what I've read on this post (Hematocrit, TRT --> systemic vascular resistance response), the body's response to higher hematocrit is vasodilation (or a BP increase), so maybe having high hematocrit actually is a factor here. I've definitely read reports here of guys who reported being...

I've been trying to figure out why some guys get this on TRT. My current best guess is that it has to do with the vasodilation properties of testosterone: The vasodilatory action of testosterone: a potassium-channel opening or a calcium antagonistic action? According to this paper, this...

Not sure it matters, but I use my soda stream. None of that fancy reverse-osmosis filtered water..that's a few steps too far down the rabbit hole for me!

I once had a total testosterone measurement of like 9 ng/dL. Turned out to be lab error. I think a human types in numbers into a computer, reading off a machine. So a mistake of that magnitude can happen. RE: your 60 hematocrit, was that from a finger prick test at a blood center? Those tests...