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  1. Jason Sypolt

    56% increase is testosterone using a testosterone booster: Say What?

    Somehow I missed the Amazon part. Amazon has for some time had a total ban in place for testosterone booster supplements because even they know that the products don't work. It costs $3000 for an application to sell any supplements on Amazon so you can get some satisfaction knowing that these...
  2. Jason Sypolt

    Hair loss

    Excess DHT can lead to thinning hair, but to become bald (androgenic alopecia), you do need the genetics for it to happen. DHT from the testisterone in TRT will accelerate the process, but it was going to happen anyway if you have the genes. There are products that can slow or reverse hair loss.
  3. Jason Sypolt

    56% increase is testosterone using a testosterone booster: Say What?

    None of those products work. Zero. The claims that are made for them are based off of dubious technicalities and careful misrepresentation of facts if any are true at all. And they are often not true. Remember that supplements have no regulation and no oversight. I tell my 13-year-old: anyone...
  4. Jason Sypolt

    Target T levels & Defy

    I can't answer the question about switching testing methodologies, that would be up to Dr. Saya as Medical Director. Patients are also certainly welcome to have a say in their labs and help select one over the other. This happens for example between selecting the LCMS testosterone test or not...
  5. Jason Sypolt

    Target T levels & Defy

    We don't aim for targets at Defy. That sets everyone up for failure. I'll explain: Each patient's treatment protocol is tailored to both how you feel (subjective) and what your biomarkers look like in lab results (objective) and also as a result of listening to you in your consults. That's why...
  6. Jason Sypolt

    Nandrolone Experiences

    Cataceous is right. Nandolone is many times more anabolic than testosterone. They both work in different ways and in same and different tissues but work synergistically together and have a magnified effect when used together. I don't think that Free T is the end all be all that some lead us to...
  7. Jason Sypolt

    Online trimix script

    I keep Sudafed on hand to put an end to the Tri-mix when I'm done with it. You have to use the 4-hour because the 12 is too slow of a release, and it has to be the behind-the-counter pseudoephedrine formulation that you sign for. You can take up to 5 30mg tablets and that will start to bring an...
  8. Jason Sypolt

    Nandrolone Experiences

    Mike is nothing short of an androgen expert in my humble opinion. I frequently have my consults with him Anabolics will compete with T for androgen receptors and some for SHBG. If the androgen (like Nandrolone) has a stronger binding affinity than T, then the T can't bind and is free.
  9. Jason Sypolt

    Low dose nandrolone with low dose testosterone

    If it were from Bob's' Compounding Shack, I would certainly agree. There is a psychological phenomenon (the name escapes me) when it comes to brand name vs generic perceptions. Basically people are given 2 of the same brand and told one is generic and one is not and not only do they...
  10. Jason Sypolt

    Low dose nandrolone with low dose testosterone

    Are you looking for potency differences? I have seen some sterility/stability reports from Empower and the samples of their T actually increase in potency over the testing period.
  11. Jason Sypolt

    Nandrolone Experiences

    I've been on 100mg per week for about 12 weeks and love it. I feel better overall, joints more mobile, libido a little higher, and some small strength and size increases. I'm injecting it 50mg BIW. No water retention or BP problems. I have not had a CBC or Lipids yet. Talk to your doctor about...
  12. Jason Sypolt

    Online trimix script

    What pharmacy did it come from and what was the strength? With a starting dose around 0.1mL, a lot of formulations will give you at least an hour. Empower's is 30/2/10 for example. Maybe Rx Buyer's Club uses a lower strength and are just erring on the side of caution without the PE and possibly...
  13. Jason Sypolt

    Low dose nandrolone with low dose testosterone

    No depression or memory problems. Never heard of Nandrolone causing those. I'm not sure how that would be possible. It depends on how much cream is absorbed I suppose, but I will guess about a 2.5:1 ratio of T to Nandrolone. I'm a little different since I have some DHT issues though. I believe...
  14. Jason Sypolt

    Low dose nandrolone with low dose testosterone

    Testosterone can't bind to the AR because Nandrolone has around a 10x stronger affinity. Plus Nandrolone like every other androgen lowers SHBG. And a lot of T is going to go unused and be gone. I've seen the same thing in myself with Oxandrolone. Total T goes from 1100 to 650 but Free T remains...
  15. Jason Sypolt

    Low dose nandrolone with low dose testosterone

    "Deca dick" only happens when you don't balance Nandrolone with testosterone. Verbally speaking, bodybuilders don't take enough T or they take no T at all and that causes oeoblems. Dosed correctly, an ncrease is likely.
  16. Jason Sypolt

    Reliable way to prevent HDL drop while on cycle and NOT on TRT ?

    Totally valid point in my mind and I either don't know enough about the subject or haven't seen enough data (or both) to be able to answer well except that I think it's simply due to fear over "low HDL" because that's bad and increases plaque in arteries further advancing atherosclerosis among...
  17. Jason Sypolt

    Why so little info on Bremelanotide (PT-141-Vyleesi)?

    Bremelanotide has been approved by the FDA and products are coming. It's only a matter of time and shouldn't be much longer of a wait to get it from retail pharmacies using insirance or compounding pharmacies with cash.
  18. Jason Sypolt

    Low dose nandrolone with low dose testosterone

    We need to keep the discussion to substances that are legal within this US. You should see that Nandrolone will suppress Estradiol. In many cases, the more DHT or DHT derivitives in you, the less Estradiol there will be. Nandrolone (and Stanozolol) does not itself aromatize at all because it is...
  19. Jason Sypolt

    Reliable way to prevent HDL drop while on cycle and NOT on TRT ?

    Why the choice of a SARM over anabolic? When I'm on Oxandrolone or Stanozolol I take fish oil and Niacin IR. I hate the Niacin - it makes me feel (and look) like I have a severe sunburn for an hour every time I take it, even with asprin. I also take NAC daily. I can keep my HDL around 40 with...
  20. Jason Sypolt

    Online trimix script

    Some of the follow up labs are determined by the treatment(s) that you are receiving. These are typical TRT follow up labs: CBC CMP-14 Lipid Panel Testosterone Free & Total Estradiol Sensitive DHEA-Sulfate TSH PSA SHBG The labs are often customized based on discussion between a patient and...
  21. Jason Sypolt

    Online trimix script

    You can email [email protected] if you need the new 2019 PE form or let me know and I will post it here for you. I can see how you're looking at it as a CYA, but it actually goes both ways for you and Defy. It's a health screening, however basic, but they should be checking your heart, and...
  22. Jason Sypolt

    Online trimix script

    A physical is not a bad idea considering what Tri-mix is and what it is for. It's a good precautionary practice. Based on feedback received, the newer wording on the single-page form should make it trivial to take it to most pharrmacies or primary care practices for a quick evaluation.
  23. Jason Sypolt

    Who's currently on T propionate?

    That article is more than a decade old and the very first sentence says that testosterone also cause fatal heart failure, which we know is not true. It also discusses high doses and use with cocaine. Not even close to what I mentioned. And I did not say that it was for life. If you read...
  24. Jason Sypolt

    Who's currently on T propionate?

    Defy can prescribe Nandrolone/Oxandrolone/Stanozolol as long as they are safe and justified. There is more data coming out showing that these drugs have beneficial effects in low (safe) therapeutic doses such as relief from joint pain or when combined with lifestyle changes reversal of metabolic...
  25. Jason Sypolt

    Who's currently on T propionate?

    I don't personally think that Prop had a place as a primary treatment. Many people report feeling their best with stability and balance. It would make a nice booster though as I said above. I don't use it - I take Enanthate and supplement a 5% cream applied to the scrotum. For close to the...
  26. Jason Sypolt

    Who's currently on T propionate?

    This makes sense, but it assumes that a steady state exists. It may not due to various reasons, or ever, particularly on a case by case basis. The fact is that no one knows how all of these processes work. I am actually a bad example because the way my body works is considerably messed up from...
  27. Jason Sypolt

    Who's currently on T propionate?

    I don't understand the purpose of the blends that some pharmacies offer. There is fear over patents and justification for compounding but using grapseed oil is enough of a difference. Some combine DHEA, Anastrozole, etc. and it's silly to do that because you can't independently dose. The same...
  28. Jason Sypolt

    Who's currently on T propionate?

    Yes. And if your SHBG is low then you have 2 rollercoasters each day. I cannot stress enough the importance of SHBG in a decision to use a fast ester. For context, I would inject 15mg at 8am. By 1pm, (I have the results somewhere) my Total T was back down to 400s. Then I would inject 15mg in...
  29. Jason Sypolt

    Who's currently on T propionate?

    I have an old thread on here where I did like it very much at first. And then things went downhill. Spike in serum T in the morning and then back to hypogonadism by afternoon. Repeat daily. If you have low SHBG then don't even think about it - it will be out of your system within just a few...
  30. Jason Sypolt

    Has anyone had erections lasting more than 3 hours with Trimix?

    When we reference "Sudafed" for priapism, we are referring to Pseudoephedrine, yes. Products containing Pseudoephedrine are restricted in the US because the chemical can be used to manufacture amphetamines. So there is a newer, Sudafed formulation that uses Phenylephrine as the active...
  31. Jason Sypolt

    Raising low prolactin

    Cabergoline has a 60-hour half life so if your PRL is still that low 3 months after stopping the drug then you have something else going on that is causing it to be so low.
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