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I believe this should be Dr Rob? I have been following the thread, and I appreciate you actually took the time to read the studies and get back here with your considerations. I learned about the QT interval and the Afib/testosterone from your writing, thanks for that. I'm not sure if you saw my...

Abstract Background Atrial fibrillation (AF) is the most common cardiac dysrhythmia associated with significant morbidity and mortality. Several small studies have reported that low serum total testosterone (TT) levels were associated with a higher incidence of AF. In contrast, it is also...

Thanks Nelson, that’s a good summary!

Thanks for sharing this one as well. I had now idea a debate was going on over here The Health Optimization Doctors RoundTable: High Hematocrit Not Important?

Increased Hb Levels Are Associated with the Incidence of Atrial Fibrillation: But Is It Related to the Occurrence of Stroke Anemia has been known to increase the incidence of atrial fibrillation (AF) in general practice. However, it is known that patients with polycythemia also increase the...

Abstract Anemia is a risk factor for cardiovascular disease, but its impact on new-onset atrial fibrillation (AF) is unclear. In this study, we investigated the effect of hemoglobin (Hb) levels and their changes on the risk of AF development in the general population of Korea. We retrospectively...

I think you would notice something is really off if your testosterone goes from 1000 to 300. I would run the test again.

@Vince is the free T measured with Ultrafiltration at Labcorp? I started using that assay for more accurate result, I find the upper limit a bit too low, unless the FT of healthy young males measured with Ultrafiltration shows a top of 22ng/dl?

Have you tested for Pregnenolone and know you need to supplement with it? did you test your Progesterone as well? What kind of oral Pregnenolone did you try?

I think so, any delivery method that puts straight Prog in circulating blood in a slower release I would think mimics the natural production the most. If there was a oral Prog in a lipid matrix so that can skip the first pass in the liver, and that it is slow released it would be great too...

I think more and more about trying to recreate a hormone pattern that is close to our physiology. I was just thinking about Progesterone not long ago, perhaps the most "physiologic" way of getting it in, being via injection. Pro, when taken orally will over convert to downstream metabolites...

there seems to be many reports on line of NAC causing insomnia, or distrubing sleep in some ways. If someone has some sort of sleep issues, I would avoid taking it at night.

I would get those tests done as well. You need to know where you are at with these hormones as well. If you have low progesterone and you bring that up, you may improve your anxiety.

Pregnenolone, Progesterone, DHEA, Thyroid, Cortisol. What is your level with that dose?

how much are you injecting daily? are you monitoring all the other hormones as well?

I'm wondering if you can still have withdrawal symptoms even if it is not a a benzodiazepine drug.

Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects H Viola 1, C Wasowski, M Levi de Stein, C Wolfman, R Silveira, F Dajas, J H Medina, A C Paladini Affiliations expand PMID: 7617761 DOI: 10.1055/s-2006-958058 Abstract The...

for sure running at supraphysiological Test level can do it, since test has an effect on the CNS. But other factors need to be taken into account here. Daily injection is a good way to see more precisely where your levels are with that particular dose.

Not sure this is just a coincidence, but for the past week I have been on 50mg apigenin, and sex drive, erections and libido have all increased.

I turned off all notification for that reason, calls texts included. I use it mainly to count my steps and keep track of my heart rate.

I see that using higher dosages seems to promote sedation, I use 50mg at bed time. how many days do you think you can use it before developing tolerance? I thought the first night worked great for me, second night still great but a bit less, 3rd night still benefited from it. Last two nights it...

That’s the brand I’m using. I started it as a sleep aid as well. It seems to be working. Hopefully it doesn’t effect hormones that much. I need to look a bit more into this.

Following up with this thread. Curios to know if anyone has seen any hormonal variation with the apigenin. The effect on the StAR was noted in an animal study, but wondering if can have an effect on E2 or DHT in humans

Hi @Nelson Vergel , have you ever completed this small pilot? Interested to know any outcome with the apigenin

I would test first before you decrease your dose. Perhaps the 20mg are working well and levels are not too high. The usual dose of oral progesterone for men is 5/10mg, I'm sure some may need more, or less. I believe there is a U shape curve with pretty much anything, Progesterone helps with...

low cortisol/aldosterone did not affect TRT for me. But TRT can certainly exacerbate an existing adrenal/thyroid issue, especially when supraphysiologic doses are used for long period of time.

I would test progesterone if I were you, just making sure you are not going to high with it. 20mg orally is a pretty high dose

What do you guys think of AutoSleep app for Apple Watch? Has anyone tried this app? I think it works better than the integrated Apple Watch tracker

Do you know your Pregnenolone/Progesterone levels? FT4/FT3 rT3 numbers?

do you know what is your Progesterone level?

What time is your supper?