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Many thanks for the in-depth replies to my concerns and putting things in a common sense perspective. According to the authors of a clinical trial https://clinicaltrials.gov/ct2/show/NCT01769157 , L-carnitine and thyroid hormone tended to antagonize reciprocally in human body. This is obviously...

3 questions for Dr. McClain: 1) Have you seen any thyroid suppression with the use of carnitine supplementation for those who are hypothyroid and on thyroid replacement (L-carnitine has been shown in many studies to suppress both T3 and T4 at the cellular level)? If so, do you think taking the...

This is an excellent forum and resource for those tapering any psych meds, especially benzos: http://survivingantidepressants.org/topic/1024-why-taper-by-10-of-my-dosage/ Basically, to avoid most withdrawal side effects and for harm reduction, the slower the taper, the better. This is a...

Anyone see that the Big Pharma US co. Sigma-Aldrich carries what looks like the real deal? The price is outrageous as you can see. Anyone know the difference between citrate and hydrochloride other than just a different carrier molecule? Enclomipheme citrate was the one used in all the research...

Just caught this new youtube video: https://www.youtube.com/watch?v=QBw_Kh4oIDQ&feature=youtu.be

Am familiar with this combo and the research. AOR has a specific powdered formula for this: http://www.aor.ca/en/product/tlc-3.0 I have tried pretty much everything in the past and continue to try OTC natural remedies that have shown limited success in some, and perhaps it's what is keeping my...

As we learn more about how elevated levels of Lp(a) can potentially kill us before anyone can determine the cause, it is imperative that everyone get this lipid marker tested frequently, especially those on any type of HRT regimen. It is entirely possible that one of the leading culprits behind...

Sorry, regarding the carnitine/theoretical risk, I know of no actual papers that directly refute the study, however, the study itself I feel is flawed for many reasons, to name a few: 1) The researchers based many of their conclusions about TMAO on research done in mice, so, we don't really...

Yes, am well aware of the TMAO/meat scare that was blasted everywhere back in 2013, much of which has been refuted/debunked: https://www.westonaprice.org/carnitine-and-heart-disease/ http://www.marksdailyapple.com/does-red-meat-clog-your-arteries-after-all/#axzz2Q55sRnAC...

Hello again, Dr. Ullis. We had some previous email exchanges back in 2010. Good to see you on Nelson's forum. I am hypothyroid and am currently treating with 1 grain dessicated thyroid and just added 25mcg Tirosint. I do not have any autoimmune issues (i.e. Hashi's). I recently started...

Yes, am familiar with Clomid being used for PCT, however, I was referring to it as a sole TRT alternative as the whole reason anyone would want to use it for that which is two-pronged - 1) to avoid testicular atrophy and azoospermia that is associated with frank TRT, and 2) less or zero...

If you were using UGL gear, that's a whole other world of risks vs. medically-supervised TRT. Just curious - did you ever try Clomid as an alternative to exogenous testosterone?

Yes, still around. Nothing new. Still in limbo on this conundrum, but haven't given up looking into workarounds. At this point, I don't think there's anything currently available that doesn't have some degree of risk, so it's all about risk management, whether it's TRT, clomiphene, or something...

I guess my question is then - what's the cutoff or level you would want to see before resuming TRT? Would you still consider TRT if your levels remained in the 500s even with proper management under the guidance of an HRT doc?

Absent low-T symptoms and with normal free and bioavailable T, what you've stated about sums it up as to when TRT is not a good choice - and possibly even harmful. With your better understanding of the risks/benefits now, it will be interesting to see how you proceed. Do you think you will ever...

This is true for anticoagulants that work by blocking Vitamin K (i.e. Coumadin), but not the case with the newer ones: http://a-fib.com/faqs-minerals-supplements-12-coq10-with-blood-thinners/

CoQ10 is known to inhibit platelet aggregation, but also has been shown to decrease the anticoagulant effects of coumadin (Warfarin), probably via differences in the clotting mechanism. Seems a bit conflicting. As far as viscosity, we are looking good: https://www.ncbi.nlm.nih.gov/pubmed/2318549

Mark Sisson's product is the best commercially available IMO, however, since many of us are allergic to chicken eggs, I chose to make my own using duck eggs (which are more nutritionally dense). Also, the Thrive Oil I use is even higher in MUFAs and lower in PUFAs than either avocado or olive oil.

I get all my foods from Whole Foods and the organic section in my local grocer. My basic recipe for my "Paleonnaise" is: 1 cup Thrive Oil 1/4 cup Extra Virgin Olive Oil 1/4 cup Avocado Oil 1 tbsp apple cider vinegar 1 tbsp freeze-squeezed organic lemon juice 2 egg yolks (I use pastured duck...

1) Bacon is great IF it is the right kind and cooked low heat (sometimes I even steam mine - no, not as tasty as fried, but still good). I get the paleo-friendly, sugar-free free-range turkey bacon from Wellshire Farms...

Sounds like you've done your homework on PUFAs. Now, it's a matter of using the same discipline with anything else in your daily life, and applying it to something you obviosuly feel is important enough so as to limit its deleterious effects. PUFAs are indeed everything you pointed out and are...

Given this, for those not already on Clomid and are seeking an alternative to TRT, it sounds better to just wait until Androxal is approved. For those already taking Clomid and experiencing elevated E2/SHBG, do you think it would take going to anastrozole?

Good news. Thanks for the update, Nelson!

Thanks to the FDA for making fatal last year's release of Androxal which is essentially clomid minus the zuclomiphene, and thus would've avoided the estrogenc double-edged sword effect of clomid. Repros apparently does not have a good rep as a pharmaceutical co., but at least the idea was novel...

Losartan has a positive therapeutic effect on fatty liver and liver fibrosis: [COMPARISON OF DIFFERENT TREATMENT REGIMENS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE] - PubMed

No, not diabetic, and taking losartan only. Here's an interesting perspective on the controversy from a physician: Dr. Dale Peterson: Wellness Clubs of America - Blog

Since I recalled you are or were taking telmisartan, I just came across this from some research and thought I should bring to your attention in case you already didn't see this conflicting data regarding ARBs (i.e. telmisartan, losartan, etc.) and cancer : Dispute Flares Inside FDA Over Safety...

Wow, I am impressed at the research you have done. Few besides myself take the time to delve into the dark waters of research as I do! Your husband is a very fortunate man to have you in his life. In addition to using high-dose omega 3s and 7, I also use all those natural fibrinolytics you...

Much appreciated again, Nelson, for posting this & keeping us abreast of these forthcoming studies that refute prior research in this area. It would be interesting to see what Glueck would have to say now that more research continues to oppose his. Since the above is only an abstract of the...

For his TRT, is he on injections, pellets, or a gel? What's his dosing protocol? Also, you mention susceptibility to hypercoagulability. Has he experienced any thrombotic events? I'm assuming he hasn't been formally tested nor diagnosed with any familial or acquired clotting disorder, otherwise...

Update: "The company anticipates an FDA approval decision by November 30, 2015 for Androxal, a potential treatment for secondary hypogonadism. The FDA is also planning to hold an advisory committee (ADCOM) meeting to discuss the approvability of Androxal, on November 3, 2015." Read more: Repros...