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Interesting hypothesis... We now know amyloid plaque is more of a side effect of the illness and probably not a cause... but his idea that it is an immune reaction that causes the amyloid secretion is interesting... Autoimmune dysfunction is a real issue in aging...

I am with Nelson here... tired of the nanny state and their well meaning bots. People should be free to do what they want, really. Part of the issue is the over regulation of these things. If we could buy those drugs from reputable makers, this would cut the risk significantly. We should also...

That is a great video... I like Rogen...

My local pharmacy...

Pregnyl here too... that's all we have in Canada... Funny how less is more with hormones...

Similar experience here... I do 500iu twice a week which I am thinking of reducing to your level (250iu twice a week) ... I want the actual minimal effective dose... But yes, it does something to my brain... makes me happier if that makes any sense... lol

Well, different modes of actions... Clomid will stimulate your own LH and FSH production, so they naturally have the normal half life... the half life of exogenous gonadotropin injected with HCG is 'LH Like' and has a way longer half life... it also I think crosses the blood brain barrier...

Thanks Cataceous, I thus wonder if the age related hypogonadism is primary in nature, that is gonads failing to produce Test thus pituitary signaling creating high level of LH would be a factor in Az ... Given this, more active men tend to keep better levels of T thus lower LH signaling... thus...

While browsing alzheimmer info for my girl's aging mother, I came accross some studies that made me think my HCG use... Elevated gonadotropin levels in patients with Alzheimer disease https://pubmed.ncbi.nlm.nih.gov/11560301/ The Contribution of Luteinizing Hormone to Alzheimer Disease...

So one should supplement with zinc at night?

Ubiqunol is so expensive... These supplements add up... I take a NAD+ precursor, multi, fish oil, magnesium, zinc cost per month is more than my Test... Anyone found a way to get quality supplemnents at lower price?

200ml? You mean 200mg, which is quite a high dose to start. I don't know why docs do this... 100mg or 120mg per week in two injection is sort of the gold standard for starting... then 6 to 8 weeks you do blood work and adjust from there...

Definitely, but filling it for a 20% reduction of exogenous test is a lot and then again maybe not if you think they were supplying 100% of the test before I started injections... Hmmm... I was just a little surprized at how much of a difference it makes

Got tested for my yearly and my T was too high ackording to my doc. My protocol was 50mg Enanthate every 3.5d ... (100mg/week total) Got me to reduce the T to 80mg per week (I did actually 84mg per week) ... but added HCG at 500iu twice a week on top of the 84mg... After 6 weeks, my total...

Neither B12 or HCG has much influence on my libido/erections... I get morning wood ok, sensitivity is mostly my issue... I can go on for hours ... almost anorgasmic... I have been taking 5000mcmg of sublingual for years... I do 84mg a week of Enanthate and 1000 week HCG... now HCG is funny, it...

The link to the study is not good... it says it is not found or has been removed... I really like to go to the source on these... because websites like healthline are really Pharma Chills... I looked for the study and could not find it... could it have been retracted?

Who paid for that study. Pharmas don't like testosterone. There is no money in testosterone and they also prefer putting men on antidepressors and other money drugs. Do you have a link to the study?

Testosterone is not the only factor in feeling well. You mentioned thyroid which is one but many other factors influence how we feel as well and it is not all fixable with exogenous chemicals. Sleep disorders are another ball game altogether and will wreck your life and energy levels. Sleep...

I tried HCG, appart from giving me by hanging balls back, I did not feel anything else... was on it for about 8 weeks... was expecting some libido changes but ... nada, nothing... Was using 500 units twice a week of Pregnyl ... I might cycle it though as I like how my balls feel better but...

Norvaline is a little iffy for me... things like this freaks me out... https://www.sciencedirect.com/science/article/abs/pii/S0887233318305782?via%3Dihub

How much do you take and what are the benefits you get from it?

I am on trt 2 years, and just added HCG 3 weeks ago, 500iu twice a week... Appart from my balls dropping, I can't say I feen much different... maybe a little clearer ... I wonder what effects on the mind HCG has because I definitely see one. My doc also had me lower my dose of T when starting...

Following, I have some on order...

Well I have a prescription for it, I use a private anti aging clinic... no tele doc here in Canada for those kind of things...

I can't quite remember, but with my insurance I think I pay 20$ for Pregnyl 10000iu ...

Pregnyl is what I get in Canada as we have almost no compounding pharmacies...

How was your free T done? My lab calculates it, so it is not a real but a calculated value... I too have low shbg and my free t (bio available) is consistently high... I inject twice a week (E3.5d)... I found that high total T value makes me real anxious, palpitations etc... took me a while to...

I guess you had a lot of advice here, I am going to add my 2 cents. TRT is not a magic bullet.. You body will take time to addapt to exogenous hormones... Now if you keep messing up with the protocol, you are setting yourself up for a bad time... ask me how I know. Why don't you just simplify...

Been there, I now inject 100mg per week which is my sweet spot... however, at higher doses 160 -140 - 120 man I was anxious and felt like shit... I used to do eod but switch E3.5D now, 50mg each shot and my levels are in the 600 to 700 and I feel great... I wish I had done the opposite, start...

TRT gave me my life back... wonder why so much resistance still in the medical community...

Interesting... So what ever your protocol, you should be able (given no medical condition preventing it) to go back to sort of pre-treatment levels... within 12 months... however with lowered SHBG? Hmm.... Pre treatment levels but maybe more free t than pre-treatment?