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If I may answer, it makes the liver produce more SHBG.

I learned several new things from this wonderful article by Dr. Wright; hadn't heard specifically of these other benefits, due to the LH receptors in other parts of the body.

I'm pretty sure he will say there is no such thing when you provide an appropriate dose of HCG--one that mimics natural LH sensitization. Otherwise, EVERYONE would be "desensitized". As far as the interview goes, I sure am looking forward to it. Well done, Nelson!

...but it is the easiest to recognize, and treat; a great place to start.

The results, I am afraid, may not be trusted. Immunoassay is not trustworthy at this low concentration of hormone. But it certainly is true low iron can cause the symptoms of which you complain. This can be an issue when patients develop polycythemia (thick blood) while on TRT, and they have...

The role of variability is fascinating, though. As I always say, "Entropy is part and parcel of youth".

Very nice article.

My pal Dr. Mark Gordon just sent me this: Is brain estradiol a hormone or a neurotransmitter? - PubMed This may explain why T gels are better for treating sexual dysfunction; they provide much more variability throughout the day. This would be in addition to increasing DHT more than shots...

Great post, Nelson. As far as the bolded statement goes, we practitioners who were properly using HCG knew this....all along the way. because we heard it from our patients every day.

That's an awesome article by Dr. Jonathon Wright. If you take your HCG shot in the morning, you will enjoy its benefits with respect to sense of well-being, and libido (adjunctive to induced testosterone production) during the day. This is because of its actions on the more peripheral...

I hope to get ahold of their data. Does anyone know what tests are they following?

Dr. Lipschultz has done a lot of great work in this area of medicine.

I have found that 40mg SC twice per week is about equal to 100mg IM in a single shot. The idea is you are clipping off the peak, and the nadir, by doing it this way. This is especially useful for guys with lower SHBG.

I really don't consider the technique injecting under the skin. My guys are putting it right into the fat. i like to inject into the fat pad right over the glutes, just like a regular IM injection, but with a shorter, smaller needle. No bruising, no extrusion of the oil, very rarely even a drop...

Thank you for the idea! I will include the codes for the major labs in the paper. I hope that helps.

I am so glad the paper was of help to you. FYI: I am releasing the 2014 updated version of my "TRT: A Recipe for Success" in June. It's got all kinds of new stuff in it (and more than twice as many pages).

He sure is. And a really nice fellow on top of that.

I'm like a broken record that the goals of treatment are health and happiness, not numbers on a piece of paper. That is because everyone has their own best "sweet spots", and laboratory analysis of hormones can be tricky business. So I always want a guy to start out by telling me how he feels...

Thank you, EP! That is very cool info. This dispels that Bro Science about warming the oil then, too. I personally use a 1/2" 29ga insulin syringe. I inject into the gluteal region, just like the old IM shots, just with a shorter needle, so it goes into the fat. This particular needle works...

Jasen, my old friend Dr. Michael Bedecs first told me about using grape seed oil at the AAMG conference a few weeks ago. He says it works much better for SC shots. Haven't tried it yet.

I have seen this, but only a couple times in many hundreds of patients. A long time ago, I decided to never be surprised by anything I see in Interventional Endocrinology. IF SHBG is high or high-normal, it can be an issue, because you then aren't getting the peak you need to get over the top...

Just to be clear, I have never said, or even implied, scientific studies are of no use in medicine. But they are not a substitute for reality; especially when so many are poorly designed, executed, evaluated, and contain false date (and/or are ghost written--as so many are these days)...

I would add, a doctor--with a reputation for success with their patients--who says "I have found this to be effective" has an opinion which should not be discounted.

This point is intrinsic to providing a cutting edge discussion about this field of medicine. That is because we are at the very cutting edge. And we are at the cutting edge ONLY because the entire world is so far behind in its ability to solve the health problems of adult males; which is, IMPO...

I now personally inject into the fat pad on top of my glutes. It's like the old IM shot, but with a shorter/smaller needle. ....looks like Vince and I need to film an update.

This thread is AWESOME! Thank you, Nelson.

"Based on the personal experience of one of us ...." THIS is where scientific studies comes from. A practitioner figures something out, or learns it by "mistake', OR A PATIENT DOES SOMETHING....and it is found to somehow make things better. Then he/she tells their colleagues, and they try it...

You mean those who were put on Arimidex WHEN THEY SHOULDN'T HAVE.

EXACTLY! YOU should be in charge of this for the LEF!

The above statement, by LEF, demonstrates a fundamental lack of understanding of laboratory methodology. I don't know who wrote it, but it could not be more wrong. I stood at the kitchen counter at William Faloon's house as couple months ago (my GF and I stayed there for the night), and showed...

You do realize this position is contrary to hundreds of scientific studies, right? THIS provides the perfect example for those who do not understand how the body works, and just rely upon studies...."scientific studies" which are poorly designed, executed and evaluated, and often containing...