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Your metformin dose is quite low, and so not surprising that you haven't yet experienced noticeable side effects. You may or may not experience them with increased dosage. But first things first: should you be taking metformin at all? Metformin is a drug. It is a relatively benign drug, but...

The 120 in the morning, is that upon arising or some time following breakfast?

I guess I'm confused. You had said "morning insulin (120) and night time was closer to 90." My question was were the 120 and 90 your serum glucose levels?

Are the numbers you cite serum glucose levels?

IIRC, you have untreated diabetes. Proper treatment would likely ameliorate many other health issues.

Not sure why so many posters simply assume the OP has NAFLD. Other than a lower-range SHBG, which is modestly correlative but by no means dispositive, I see no basis for such a diagnosis. And in fact his very low triglycerides are usually inversely correlated with NAFLD. A proper diagnosis...

This sort of metadata analysis is utterly worthless for any purpose other than developing an hypothesis to test with a clinical study, for the reasons given by Guided_by_Voices and others. Don't waste your time worrying about it. Even if there were a difference between SFAs and MUFAs/PUFAs...

As per an earlier post of mine, I could not tolerate the side effect of pounding heartbeat I got from doxazosin. I am on tamsulosin now. No pounding heartbeat, good effect on erections and libido. Am I correct that your observation was that tamsulosin was indeed superior to alfuzosin for...

I have a supply of Doxazosin and have tried to go on it a few times, but have gone off each time due to se of pounding heartbeat. This appears to be not uncommon. Each time I gave it quite a few days (one time more than two weeks) to see if se would reduce/subside, but it never did. It was...

Not per se, but since you're asking, the overall tone could be construed as condescending, to which you yourself alluded. Many of your other points were good, although I did disagree with some. Yes, that is the problem with many of the ADA guidelines and why diabetes is grossly underdiagnosed...

Let's start with the fact that the mechanisms of action of metformin are only grossly understood, more deduction from results than fully mapped-out biochemistry. When anyone, including the NIH, makes statements regarding such they must be taken as likely hypotheses rather than gospel. But...

In your situation, the other option if you are concerned would be to stop metformin before your get-together. Three days prior is probably fine (especially if you're on the immediate-release version). A maximum of two weeks prior if you are the worrying type and want to be absolutely certain.

Alcohol, in and of itself, does not typically raise serum glucose, even in diabetics. It is generally prioritized in hepatic metabolism and therefore merely delays, but neither increases nor decreases, blood sugar changes resulting from dietary intake. Of course, if the alcohol ingested...

It can be ordered through All Day Chemist or Reliable Rx Pharmacy in India (some say without prescription). It's a perfectly good generic. Very cheap. That was not the question. The statement was that metformin is most effective when combined with a low-carb diet. That is, it generally...

It wasn't designed to be taken that way, and it might be safe and effective or it might not. But why do so? Metformin is a very cheap drug. I would just purchase some of the instant-release form. Its mechanism of action is only generally understood, but metformin does not block the...

When I said serious side effects might not be apparent for some time, I meant a connection between the drug and the side effect might not be realized by the medical community for some time. The serious damage to the individual could occur quite quickly. Coffee has been drunk in our society...

If your body is not compensating properly for that release, it's not a different problem, it's diabetes. Constant spikes don't lead to diabetes, they are diabetes. I would not be so quick to be a guinea pig. I reiterate, there are no supplements proven effective in controlling diabetes...

Glycogenolysis and gluconeogenesis occur frequently in everyone in response to many common stimuli (awakening, exercise, adrenaline release, etc.). In those with truly normal blood sugars, the body's homeostasis mechanisms produce the correct release of endogenous insulin to precisely control...

Not in and of itself, if that is close to one's average fasting level. But this is far below the other fasting levels, which are generally well into the 90s (concerning in and of itself), and only appeared after a huge upward spike. It's what is referred to as "reactive hypoglycemia" and is...

I am not your doctor. Proper diagnosis would require taking a history, conducting a physical exam, and ordering and reviewing labs (including but not limited to an oral glucose tolerance test). But since you've asked for opinions on the serum glucose levels posted, I'd say that a number of...

Have you recently measured fasting and post-prandial serum glucose levels?

Are you diabetic? If so, are your blood sugar levels consistently within the parameters for those without diabetes?

Curious as to what are the benefits you are seeing at that dose. Is there a measurable reduction in your serum glucose levels? Most adult males see no significant reduction in blood sugar levels at metformin doses below 1,500 mg./day.

I would consider having a coronary calcium scan if there were a course of treatment proven to reverse coronary artery calcification. To my knowledge, there is no clinical evidence of such.

Only if the cited study the conclusion is based on is a rigorous and properly designed clinical trial with robust statistical significance. This study is nothing of the kind. Not even close. You're correct, although actually closer to 20x. Studies with hazard ratios this low are simply not...

I have the greatest respect for Nelson and hope to hear his views. If you will indulge me, my own view is: 1) metformin is a drug; 2) all drugs have side effects; and 3) a drug should only be taken if its therapeutic benefit outweighs the risk of its side effects. Metformin's primary benefit...

Perhaps, although I would presume 1mg./day unless otherwise stated (it wasn't). Even 1mg./week is still quite a bit more than typically prescribed by most competent TRT clinicians. Again, the only effect that even managed to achieve statistical significance (meaning it crossed the threshold of...

The one cited study was a very small one in which young men not on TRT were given 1mg./day of anastrazole, a dose 10 or 20 times that which competent TRT doctors are prescribing to their patients. Even at this very large dose, as noted in the study, "[t]here were no significant changes in...

Like all things having to do with serum glucose, there is likely to be significant individual variation in reaction to whey protein. It raised Vince's fasting glucose and HgbA1c dramatically (and mine). It may, or may not, have a similar effect on yours.

Great case study; wish there were more like it and some RCTs (not holding my breath). But FWIW, although the patient's HgbA1c and fasting glucose levels at the end of the study were greatly improved and under ADA standards would no longer indicate an unequivocal diagnosis of diabetes, they are...

Berberine is not something to fool around with. It does seem to work to some degree, but it may do so by affecting your liver in potentially dangerous ways. It has not undergone the rigorous testing process to which all FDA-approved prescription drugs are subjected, much less evaluated for...